Calcium phosphate based dental restoration material for treating dentin hypersensitiveness

A technology for dentin hypersensitivity and dental restoration, applied in dentistry, dental preparations, dental prostheses, etc., can solve problems such as short duration of action, instability, and repeated treatment, so as to improve long-term effectiveness and not be easily corroded Effect

Inactive Publication Date: 2013-12-04
TSINGHUA UNIV
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  • Abstract
  • Description
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Problems solved by technology

The current treatment methods for dentin hypersensitivity have shortcomin

Method used

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  • Calcium phosphate based dental restoration material for treating dentin hypersensitiveness
  • Calcium phosphate based dental restoration material for treating dentin hypersensitiveness
  • Calcium phosphate based dental restoration material for treating dentin hypersensitiveness

Examples

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Embodiment 1

[0019] Example 1. Amphiphilic functional polypeptide and nano-hydroxyapatite are used to treat dentin hypersensitivity

[0020] Polypeptide preparation: the amino acid sequence of the amphipathic polypeptide is EEEEEEEEEDSESSEEDR (SEQ ID NO: 1), which is artificially synthesized, and three serines in it have been phosphorylated, and its structural formula is shown in formula I: The indicated polypeptide is referred to as E8DS polypeptide.

[0021]

[0022] Preparation of nano-hydroxyapatite: 0.25 g of hydroxyapatite powder (molecular weight 502.31, purchased from China Chemical Reagent Co., Ltd.) was dissolved in 10 ml of hydrochloric acid solution with a concentration of 0.5 mol / L to prepare a solution. Then dripping concentration is the sodium hydroxide solution of 0.5mol / L, causes hydroxyapatite precipitation, until solution pH value reaches about 8.5, generates a large amount of white flocculent nano-hydroxyapatite precipitations in the solution at this moment, then use...

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Abstract

The invention discloses a dental restoration material for treating the dentin hypersensitiveness. The dental restoration material for treating the dentin hypersensitiveness is formed by amphiphilic functional polypeptide firstly smeared on the surface of a dentin and nano-hydroxyapatite subsequently smeared on the polypeptide processed surface of the dentin; the polypeptides and the nano-hydroxyapatite are respectively independently packaged; and the amino acid sequence of the polypeptides is represented by SEQ ID NO:1, and serine in the amino acid sequence is phosphonated. Experiments prove that the material can successfully plug exposed dentinal tubules, and forms a compact hydroxyapatite mineral layer on the surface of the dentinal. The corrosion is difficult after the plugging, so the long term effectiveness of the plugging treatment is improved, and the material is very important to treat the dentin hypersensitiveness.

Description

technical field [0001] The invention relates to a dental restorative material based on functional polypeptide and nanometer calcium phosphate for treating dentin hypersensitivity. Background technique [0002] Dentin hypersensitivity is a common dental disease, and its symptom is that the teeth will produce painful responses to external stimuli such as cold, hot, sour and sweet. There are many causes of dentin hypersensitivity, such as loss of enamel at the crown and loss of cementum at the root due to gingival recession. The classic theory holds that the root cause of dentin hypersensitivity is that the interstitial fluid in the exposed dentin tubules will flow due to external stimuli, thereby stimulating the nerve receptors in the pulp cavity and triggering a pain response. The current treatment methods for dentin hypersensitivity all have shortcomings such as short duration of action, instability, and need for repeated treatments. Contents of the invention [0003] An...

Claims

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Application Information

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IPC IPC(8): A61K6/033A61K6/02A61K6/838
Inventor 王秀梅王琼
Owner TSINGHUA UNIV
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