Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of compound capsule containing ilaprazole sodium composition and preparation method thereof

A technology for ilaprazole sodium and ilaprazole sodium intestines, which is applied in the field of compound capsules containing ilaprazole sodium composition and its preparation, can solve the problems of large adverse reactions and slow onset of effects, and achieve adverse reactions Low cost, high curative effect, cheap price

Active Publication Date: 2016-01-27
LIVZON GROUP LIVZON PHARMA FACTORY +1
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the adverse reactions are large and the onset is slow
There is no compound preparation of ilaprazole sodium, amoxicillin and clarithromycin on the market, and the application of this patent can make up for this gap

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of compound capsule containing ilaprazole sodium composition and preparation method thereof
  • A kind of compound capsule containing ilaprazole sodium composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0029] The preparation of ilaprazole sodium enteric-coated pellets is carried out in a fluidized bed granulation coating machine, and the preparation process is the coating of the main drug layer, the coating of the isolation layer, the coating of the neutral layer, and the coating of the enteric layer;

[0030] Wherein, 1) the specific operations of the main drug layer coating are:

[0031] Take 20-40mL of purified water, under stirring, slowly add 0.2-0.4g of anhydrous sodium carbonate as an acid-base regulator, after the dissolution is complete, sequentially add 1.0-2.0g of hydroxypropyl methylcellulose as a binder, add 0.2 -0.4g polysorbate-80 as a solubilizer, after the dissolution is complete, add ilaprazole sodium in the dark, and stir into a uniform suspension; put the blank ball core in a fluidized bed granulation coating machine, boil Air volume 20-40Hz, jet pressure 0.1-0.3MPa, material temperature 35-40°C, spray speed 2.0-4.0mL min -1 , making the main drug layer ...

Embodiment 1

[0049] A compound capsule is composed of ilaprazole sodium enteric-coated pellets, clarithromycin sustained-release pellets and amoxicillin sustained-release pellets.

[0050] Prescription 1:

[0051] Ilaprazole Sodium 7.5mg

[0052] Clarithromycin 500mg

[0053] Amoxicillin 1000mg

[0054] The preparation of ilaprazole sodium enteric-coated pellets is carried out in a fluidized bed granulation coating machine, and the preparation process is the coating of the main drug layer, the coating of the isolation layer, the coating of the neutral layer, and the coating of the enteric layer;

[0055] Wherein, 1) the specific operations of the main drug layer coating are:

[0056] Take 30mL of purified water, under stirring, slowly add 0.3g of anhydrous sodium carbonate as an acid-base regulator, sequentially add 1.5g of hydroxypropyl methylcellulose, 0.3g of polysorbate-80 as a solubilizer, and add Aipu Larazole sodium, stirred into a uniform suspension; put the blank pellet core i...

Embodiment 2

[0074] A compound capsule is composed of ilaprazole sodium enteric-coated pellets, clarithromycin sustained-release pellets and amoxicillin sustained-release pellets.

[0075] Prescription 2:

[0076] Ilaprazole Sodium 5mg

[0077] Clarithromycin 400mg

[0078] Amoxicillin 900mg

[0079] The preparation of ilaprazole sodium enteric-coated pellets is carried out in a fluidized bed granulation coating machine, and the preparation process is the coating of the main drug layer, the coating of the isolation layer, the coating of the neutral layer, and the coating of the enteric layer;

[0080] Wherein, 1) the specific operations of the main drug layer coating are:

[0081] Take 20 mL of purified water, add 0.4 g of anhydrous sodium carbonate, sequentially add L0 hydroxypropyl methylcellulose, add 0.4 g of polysorbate-80, and add ilaprazole sodium in the dark, and stir to form a uniform suspension; The boiling air volume is 20Hz, the jet pressure is 0.3MPa, the material temperat...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a compound capsule containing an ilaprazole sodium composition, and a preparation method of the compound capsule. The capsule comprises an ilaprazole sodium enteric pellet, a clarithromycin sustained-release pellet and an amoxicillin sustained-release pellet, wherein a prescription mainly contains 5-10mg ilaprazole sodium, 400-600mg clarithromycin and 900-1100mg amoxicillin. The capsule has a remarkable effect on treating a peptic ulcer, and has the advantages that the capsule becomes effective quickly, and is high in effect, convenient to take and low in cost; the bioavailability can be improved; and helicobacter pylori can be killed thoroughly.

Description

technical field [0001] The invention belongs to the field of pharmacy, and more specifically relates to a compound capsule containing ilaprazole sodium composition and a preparation method thereof. Background technique [0002] Peptic ulcer (peptic ulcer) is one of clinically common and frequently-occurring diseases. my country is a high-incidence area for ulcers. According to statistics, about 10% of the population has suffered from this disease in their lifetime. Clinically, duodenal ulcer is more common than gastric ulcer, and the ratio of the two is about 1.56-5.6:1. Gastric ulcer and duodenal ulcer are chronic diseases with high recurrence coefficient, and require long-term treatment, especially for patients with gastric ulcer and duodenal ulcer caused by Helicobacter pylori infection. For patients, the price factor of medicines is very important. Therefore, the majority of patients urgently need products with good curative effect, high safety, low price, small adver...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/48A61P1/04A61P31/04A61K31/43A61K31/4439
Inventor 侯雪梅郭国岭金鑫徐晓陈剑解荷芝向双
Owner LIVZON GROUP LIVZON PHARMA FACTORY