Method for quickly granulating traditional Chinese medicinal spray-extract anti-cough tablets

Abstract

The invention relates to a method for quickly granulating traditional Chinese medicinal spray-extract anti-cough tablets. The method is characterized by comprising the following steps of: uniformly mixing starch and spray powder which are different in mass percent by using a V-type mixer on the basis of wet granulation; blowing to suspend medicinal powder at a specified temperature and spraying a granulation wetting agent at the same time, wherein the medicinal powder comes into contact with the atomized wetting agent to form granules; drying the granules with hot air; repeating the steps of suspension, granulation and drying again and again until the medicinal powder is completely formed into granules and the granules reach the specified moisture content. The method is simple and quick; soft material preparation, granulation and drying are all completed in the same equipment, and 110kg of granules can be made in 70 minutes, the efficiency is 4-5 times that of a traditional method, materials are heated uniformly, the preparation time is short, and the granule pollution rate in the preparation process is low. Furthermore, the yield of the granules is not limited by the amount of starch, and qualified granules can be obtained according to the proportion in the method provided by the invention.

Description

technical field [0001] The invention relates to a rapid granulation method for cough-relieving tablets of traditional Chinese medicine spray extract. Background technique [0002] The granulation methods commonly used in traditional Chinese medicine include: wet granulation, dry plate-making, spray granulation, etc. The appropriate granulation method can be selected according to the composition of the prescription, the preparation process and the characteristics of the required granules. [0003] Dry granulation is mostly the granulation of the whole extract of traditional Chinese medicine, and most of them are the granulation of the whole spray extract with large prescription dosage and no auxiliary materials. The spray-dried fine powder is directly dry-pressed into tablets by using special pressing equipment, and then Break the flakes into small particles. Although this method is simple, it must be equipped with special equipment, and the granules made by the dry method a...

AI Technical Summary

Problems solved by technology

The disadvantages of this preparation method are: long operating procedures, poor continuity, high probability of contamination, especially hundreds of kilograms of wet particles, placed on hundreds of stainless steel trays, which are concentrated in high-concentration ethanol in the workshop, which not only has the potential to easily The danger of flammability and explosion is also affected by the temperature and humidity of the workshop. If the humidity exceeds 50% and the temperature exceeds 25°C, hundreds of kilograms of wet granules are not stirred in time, and it is easy to absorb moisture and become syrupy, resulting in Granulation failure

It must be dried and re-granulated, the ingredients are lost, and the time is doubled

Under smooth conditions, 3-5 operators are needed to complete the preparation of more than 100 kilograms of granules in one day