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Preparation method for aerogel particle in cavity structure

A technology of airgel and microparticles, which is applied in the preparation of microspheres and microcapsule preparations. It can solve the problems of low drug loading, easy separation and drop of microparticles, and low porosity, so as to prolong the release time and improve the preparation method. Simple, controllable, low-cost effects

Active Publication Date: 2013-12-11
常州循天节能科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This SiO 2 Mesopores assembled with magnetic Fe 2 o 3 Microparticle nanocomposites can be applied to drug loading and sustained release, but the magnetic Fe 2 o 3 Particles are easy to separate and fall during the carrying process, and the cavity is filled with Fe 2 o 3 Microparticles allow for lower drug loading
relative to SiO 2 Airgel, Mesoporous SiO 2 lower porosity

Method used

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  • Preparation method for aerogel particle in cavity structure
  • Preparation method for aerogel particle in cavity structure
  • Preparation method for aerogel particle in cavity structure

Examples

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Embodiment 1

[0052] (Example 1, SiO with cavity structure 2 Preparation method of airgel particles)

[0053] The preparation of SiO with a cavity structure in this embodiment 2 The method of airgel particles comprises the following steps:

[0054] ① SiO 2 Preparation of Wet Gels.

[0055] Stir and mix alkoxysilane, alcohol solvent and pure water under a water bath at 25°C to 60°C for 10min to 60min, add an acidic catalyst dropwise to the above mixture, and stir for 30min to 80min to fully hydrolyze the alkoxysilane to obtain a precursor Then add a basic catalyst dropwise to the acid-catalyzed hydrolyzed material to adjust the pH value of the material to 6-8, so that the precursor sol undergoes a rapid polycondensation reaction, and a colorless and transparent wet gel is obtained after the polycondensation reaction is completed. SiO obtained after static aging for 2h to 15h (6h in this example) 2 Wet gel is ready for use.

[0056] The ratio of the amount of the above-mentioned alkoxysil...

Embodiment 2

[0088] (Example 2, Fe with cavity structure 2 o 3 / SiO 2 Preparation method of airgel particles)

[0089] The preparation of the present embodiment has Fe with cavity structure 2 o 3 / SiO 2 The method of airgel particles comprises the following steps:

[0090] ①O / W emulsion preparation. Dissolve the iron salt in deionized water to prepare an iron salt solution with a concentration of 0.05 mol / L to 3 mol / L and use it as the water phase; stir and mix the alkoxysilane and the iron salt solution as the oil phase in a water bath, An O / W emulsion is formed. The temperature of the water bath is 20°C to 60°C.

[0091] The iron salt is one of ferric chloride, ferric nitrate, ferric sulfate or a combination of any two or three, in this embodiment it is FeCl 3 ·6H 2 O.

[0092] The ratio of the amount of alkoxysilane to the iron salt is (5-50): (1-10).

[0093] The alkoxysilane is one of ethyl silicate, methyl silicate, propyl silicate and polysiloxane E40, E32, E28 or a comb...

Embodiment 3

[0110] (embodiment 3, hollow Fe 2 o 3 / SiO 2 Preparation method of airgel microspheres)

[0111] The preparation of the present embodiment hollow Fe 2 o 3 / SiO 2 The method all the other of airgel microsphere is identical with embodiment 2, difference is:

[0112] In step ①, FeCl with a molar ratio of 1:1 3 ·6H 2 O and FeCl 2 4H 2 O was dissolved in deionized water, and the concentration of iron ions in the solution was 1mol / L. Stir and mix TEOS and iron ion solution in a water bath to form an O / W emulsion. The mass ratio of TEOS to iron ions was 50:5.

[0113] The molar ratio of TEOS to sodium hydroxide in step ③ is 50:0.5.

[0114] In step ④, add hexadecyltrimethylammonium chloride and deionized water to the material after the alkali-catalyzed reaction in step ③, continue to stir for 2 hours, leave it to stand for aging for 1d; then carry out solid-liquid separation, and use deionized water, acetone washing.

[0115] In step ⑤, soak the gel washed in step ④ in ...

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Abstract

The invention discloses a preparation method for an aerogel particulate in a cavity structure. The preparation method for a SiO2 aerogel particulate in the cavity structure comprises the following steps of wrapping metal particles by SiO2 aerogel, grinding and separating the SiO2 aerogel which wraps the metal particles, and drying to obtain the aerogel particulate which wraps the metal particles and is of a required size; soaking the aerogel particulate which wraps the metal particles in dilute acid, and slowly dissolving the metal particles; after the metal particles are completely dissolved, forming a cavity in the SiO2 aerogel particulate which originally wraps the metal particles due to dissolution of the metal particles, and performing washing, drying and heat treatment to obtain the SiO2 aerogel particulate in the cavity structure. The preparation method is simple. The prepared aerogel particulate in the cavity structure is stable in structure and can be used for medicine carrying and controlled release, and the particle size of the particulate is 1 to 10 microns.

Description

technical field [0001] The invention relates to a preparation method of an airgel material, in particular to a preparation method of airgel particles with a cavity structure. Background technique [0002] Airgel (aerogels) usually refers to a lightweight nano-solid material that aggregates with nano-scale ultrafine particles to form a nano-porous network structure, and fills the network pores with a gaseous dispersion medium. Airgel is a solid, but 99% gas, and looks like a cloud. [0003] Silica aerogels are the most common aerogels. SiO 2 Airgel has a unique and adjustable structure and thermal, mechanical, electrical, optical, acoustic, magnetic and chemical properties, and its density is between 3 and 800 mg / cm 3 Between, the specific surface area is 200~1000m 2 / g, the pore size is between 2nm and 50nm, the porosity is as high as 80% to 99.8%, the refractive index is between 1.01 and 1.06, the thermal conductivity is as low as 0.013W / mK, and the dielectric constant ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02
Inventor 徐俊伟敖文亮林明通陈精明
Owner 常州循天节能科技有限公司
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