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Combined medicine of pseudo-ginseng extract, ligusticum wallichii extract, safflower carthamus extract, radix puerariae extract and hawthorn extract as well as preparation and application of combined medicine

A technology of Chuanxiong extract and safflower extract, which is applied to the combination method and preparation method, can solve the problems of unclear dose-effect relationship, inconsistent active ingredients, quantification of index ingredients, etc.

Inactive Publication Date: 2013-12-18
无锡市天赐康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since Chinese medicinal materials are affected by the place of origin, planting method and climate, the active ingredients of each batch of medicinal materials may be inconsistent. This kind of preparation is made directly with the prescribed amount of medicinal materials and a simple process, without quantifying the index components. Dose-effect The relationship is unclear, resulting in inconsistent quality of each batch of products, thus affecting the efficacy of drugs

Method used

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  • Combined medicine of pseudo-ginseng extract, ligusticum wallichii extract, safflower carthamus extract, radix puerariae extract and hawthorn extract as well as preparation and application of combined medicine
  • Combined medicine of pseudo-ginseng extract, ligusticum wallichii extract, safflower carthamus extract, radix puerariae extract and hawthorn extract as well as preparation and application of combined medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Prescription (prescription 3):

[0041] Panax notoginseng extract (containing total saponins 3.74mg×1000) 10.92g

[0042] Chuanxiong Extract (Containing Ferulic Acid 0.0259mg×1000) 11.6g

[0043] Safflower extract (containing hydroxysafflower yellow A0.55mg×1000) 50.96g

[0044] Pueraria root extract (containing puerarin 17.33mg×1000) 136.04g

[0045] Hawthorn extract (containing total flavonoids of hawthorn 1.58mg×1000) 23.4g

[0046] Preparation method: weigh Panax notoginseng extract, Ligusticum chuanxiong extract, safflower extract, kudzu root extract and hawthorn extract according to the prescription, add appropriate amount of excipients, mix evenly, and fill in capsules to obtain 1000 capsules.

Embodiment 2

[0048] Prescription (prescription 3):

[0049] Panax notoginseng extract (containing total saponins 3.74mg×1000) 10.92g

[0050] Chuanxiong Extract (Containing Ferulic Acid 0.0259mg×1000) 11.6g

[0051] Safflower extract (containing hydroxysafflower yellow A0.55mg×1000) 50.96g

[0052] Pueraria root extract (containing puerarin 17.33mg×1000) 136.04g

[0053] Hawthorn extract (containing total flavonoids of hawthorn 1.58mg×1000) 23.4g

[0054] Beeswax 50g

[0055] Appropriate amount of gelatin

[0056] Appropriate amount of glycerin

[0057] Paraffin oil amount

[0058] Preparation method: take beeswax, dissolve it with slight heat, add notoginseng extract, chuanxiong extract, safflower extract, kudzu root extract, hawthorn extract and paraffin oil and other suitable excipients, stir well, colloid mill to grind evenly, reduce Pressure degassing, medicine hydraulic pressure makes 1000 soft capsules.

Embodiment 3

[0060] Prescription (prescription 3):

[0061] Panax notoginseng extract (containing total saponins 3.74mg×1000) 10.92g

[0062] Chuanxiong Extract (Containing Ferulic Acid 0.0259mg×1000) 11.6g

[0063] Safflower extract (containing hydroxysafflower yellow A0.55mg×1000) 50.96g

[0064] Pueraria root extract (containing puerarin 17.33mg×1000) 136.04g

[0065] Hawthorn extract (containing total flavonoids of hawthorn 1.58mg×1000) 23.4g

[0066] Sucrose 250g

[0067] Dextrin 150g

[0068] Whipped starch 50g

[0069] Fragrance 1.5ml

[0070] Preparation method: Weigh the prescribed amount of Panax notoginseng extract, Chuanxiong extract, safflower extract, Pueraria root extract, hawthorn extract, sucrose and dextrin, crush them through a 100-mesh sieve, and mix thoroughly for half an hour; beat the starch Make a 10% starch slurry and let it cool for later use. Add the starch slurry to the mixed material under stirring to make a soft material, pass through a 14-mesh sieve, ...

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Abstract

The invention provides a combined medicine of a pseudo-ginseng extract, a ligusticum wallichii extract, a safflower carthamus extract, a radix puerariae extract and a hawthorn extract, relates to an extracting and combining method and a preparation method of a pharmaceutic preparation, and in particular relates to an extracting and combining method of the combined medicine of the pseudo-ginseng extract, the ligusticum wallichii extract, the safflower carthamus extract, the radix puerariae extract and the hawthorn extract, and a preparation of the combined medicine. The combined medicine comprises the pseudo-ginseng extract, the ligusticum wallichii extract, the safflower carthamus extract, the radix puerariae extract and the hawthorn extract in a weight ratio of (10.92-43.68): (34.01-136.04): (12.74-50.9): (5.8-11.6): 23.4, wherein the total saponins in the pseudo-ginseng extract cannot be below 20.0%; ferulic acid in the ligusticum wallichii extract cannot be below 0.2%; hydroxysafflor yellow A in the safflower carthamus extract cannot be below 1.0%; puerarin in radix puerariae extract cannot be below 10.0%; the total hawthorn flavonoids in the hawthorn extract cannot be below 5.0%.

Description

technical field [0001] The invention relates to a combination medicine of Panax notoginseng extract, Rhizoma Chuanxiong extract, safflower extract, kudzu root extract and hawthorn extract and its preparation and application, which relate to the extraction, combination method and preparation method of a pharmaceutical preparation, and more Specifically, it relates to the extraction, combination method and preparation of a combination medicine of Panax notoginseng extract, Chuanxiong extract, safflower extract, pueraria root extract and hawthorn extract. Background technique [0002] Cardiovascular and cerebrovascular diseases are common and frequently-occurring diseases that endanger human life and health, and are the leading cause of death. They have the characteristics of high morbidity, high mortality and high recurrence rate, and are the main chronic non-communicable diseases that cause serious social and economic burdens. one. In my country, cardiovascular and cerebrova...

Claims

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Application Information

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IPC IPC(8): A61K36/734A61P1/08A61P9/10
Inventor 张国清潘亚莲
Owner 无锡市天赐康生物科技有限公司
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