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A method for preparing high-strength chitosan/cellulose composite hydrogel film

A technology of composite hydrogel and hydrogel film is applied in the field of preparing chitosan/cellulose composite hydrogel film, which can solve the problems of damage to the mechanical properties of products, increase in molecular weight polydispersity, and decrease in molecular weight, etc. The effect of avoiding instability and simple preparation process

Inactive Publication Date: 2016-01-27
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the glycosidic bonds of the hemiacetal structure in the chitosan molecule continue to undergo acid-catalyzed hydrolysis, resulting in a decrease in molecular weight and an increase in molecular weight polydispersity, resulting in damage to the mechanical properties of the product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1) Take 1g of chitosan, 2g of cellulose, 8g of lithium hydroxide, 8g of sodium hydroxide, 12g of urea, and 169g of water. Mix the above components, swell at 10°C for 1 hour, freeze at -60°C for 4 hours, thaw at room temperature, filter, centrifuge, and defoam to obtain a transparent chitosan / cellulose alkaline system solution;

[0016] 2) Inject the chitosan / cellulose alkaline system solution prepared in step 1) into a film-forming mold with a thickness of 0.5mm, and soak it in a coagulation bath at 30°C to form a chitosan / cellulose hydrogel film. Then rinse with deionized water until the pH is 7.0. The coagulation bath used was H with a mass concentration of 18.0% 2 SO 4 aqueous solution. The maximum tensile strength of the chitosan / cellulose hydrogel film prepared in this example is: 0.67MPa.

Embodiment 2

[0018] 1) Take 12g of chitosan, 2g of cellulose, 8g of lithium hydroxide, 8g of sodium hydroxide, 12g of urea, and 158g of water. Mix the above components, swell at 25°C for 3 hours, then freeze at -40°C for 4 hours, thaw at room temperature, filter, centrifuge, and defoam to obtain a transparent chitosan / cellulose alkaline system solution;

[0019] 2) Inject the chitosan / cellulose alkaline system solution prepared in step 1) into a film-forming mold with a thickness of 3.0mm, and soak in a coagulation bath at 30°C to form a chitosan / cellulose hydrogel film. Then rinse with deionized water until the pH is 7.0. The coagulation bath used was H with a mass concentration of 10.0% 2 SO 4 A mixture of aqueous solution and ethanol at a volume ratio of 1:10. The chitosan / cellulose hydrogel film tensile strength that this example makes is: 2.28MPa.

Embodiment 3

[0021] 1) Take 6g of chitosan, 16g of cellulose, 12g of lithium hydroxide, 2g of sodium hydroxide, 12g of urea, and 152g of water. Mix the above components, swell at 15°C for 2 hours, then freeze at -20°C for 8 hours, thaw at room temperature, filter, centrifuge, and defoam to obtain a transparent chitosan / cellulose alkaline system solution;

[0022] 2) Inject the chitosan / cellulose alkaline system solution prepared in step 1) into a film-forming mold with a thickness of 1.0mm, and soak it in a coagulation bath at 30°C to form a chitosan / cellulose hydrogel film. Then rinse with deionized water until the pH is 7.0. The coagulation bath used is a mass concentration of 8.0% H 2 SO 4 A mixture of aqueous solution and ethanol at a volume ratio of 10:1. The chitosan / cellulose hydrogel film tensile strength that this example makes is: 1.94MPa.

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Abstract

The invention discloses a method for preparing a high-strength chitosan / cellulose composite hydrogel film. The method comprises the following steps of by taking chitosan, cellulose, lithium hydroxide, sodium hydroxide, urea and water according to weight percentage, mixing the components, obtaining a transparent chitosan / cellulose alkaline system solution through swelling, freezing, unfreezing, filtering, centrifuging and defoaming, pouring the chitosan / cellulose alkaline system solution into a film forming die and soaking in a coagulating bath to obtain the chitosan / cellulose hydrogel film. The method has the advantages that the preparation process is simple; the high-strength hydrogel film is prepared from the natural biomacromolecule chitosan and cellulose; the chitosan and the cellulose are not subjected to special modification or functional group modification and exist in the gel in the form of non-derivatives; by utilizing the alkaline system solution, the high-strength composite hydrogel film is obtained, the instability caused by acid catalytic hydrolysis in the acid chitosan solution and the limit of poisonous organic solvents applied to the biomedical field are avoided at the same time.

Description

technical field [0001] The invention relates to a method for preparing chitosan / cellulose composite hydrogel film. Background technique [0002] Hydrogel is a kind of hydrophilic three-dimensional network polymer with a certain degree of crosslinking, and its water absorption weight can reach tens to hundreds of times of its own polymer weight. Hydrogel itself is insoluble in water, can maintain its shape and characteristics in water, and can quickly swell to an equilibrium volume in water, and can also be dehydrated and deswelled under certain conditions. Due to its good hydrophilicity and biocompatibility, hydrogels have been widely used in thermal insulation, sanitary products, drug loading, burn dressings, postoperative anti-adhesion and other fields, and will have wider application prospects. [0003] Cellulose is the most abundant natural polysaccharide resource in nature. Due to its biodegradability, biocompatibility, safety and non-toxicity, it has become a good mat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J5/18C08J3/075C08L5/08C08L1/02
Inventor 胡巧玲聂景怡王征科
Owner ZHEJIANG UNIV
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