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Liquid oral rehydration salt

A liquid rehydration salt and liquid technology, applied in the field of medicine, can solve the problems of difficulty in exerting a therapeutic effect, difficult to master the dosage, and difficult to accurately measure the amount of water, and achieve the effects of medication safety, dosage safety, and convenient storage.

Active Publication Date: 2015-01-07
北京亿灵医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The liquid rehydration salt of the present invention has precise dosage of water and is precisely formulated into a solution with an osmotic pressure of 245 mosm / l, which solves the inconvenience of using traditional powders, the difficulty in accurate water consumption, and the difficulty in controlling the dose. Problems such as difficulty in exerting therapeutic effects under water conditions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Liquid Oral Rehydration Salts

[0029] prescription:

[0030] Sodium chloride 2.6g potassium chloride 1.5g sodium citrate 2.9g anhydrous glucose 13.5g purified water 1000ml

[0031] Preparation:

[0032] 1. Take 80% of the amount of purified water and add it to the concentrated mixing tank, start stirring, add sodium chloride, potassium chloride, sodium citrate, and anhydrous glucose in sequence, and stir for 15 minutes to dissolve.

[0033] 2. Filter the above solution into the dilute mixing tank, add water to the full amount, and start stirring.

[0034] 3. Divide the prescription into 8 parts, one part is a solution with a pH value of 7.3 that is not adjusted with a pH regulator, and the rest is a solution that is adjusted to a different pH value with citric acid, filtered, and filled in a 100ml oral liquid bottle, 115 Sterilize at ℃ for 30 minutes, and measure the glucose content (optical rotation, liquid phase).

...

Embodiment 2

[0038] Example 2 Liquid Oral Rehydration Salts

[0039] prescription:

[0040] Sodium chloride 2.6g potassium chloride 1.5g sodium citrate 2.9g anhydrous glucose 13.5g stevia 2g purified water 1000ml

[0041] Preparation:

[0042] 1. Dissolve the weighed raw and auxiliary materials in 950ml of purified water, and stir to make them evenly mixed.

[0043] 2. Adjust the pH to 4.36 with phosphoric acid.

[0044] 3. Fill the above solution with water to full volume, filter, boil for 10 minutes, and pass in circulating water to rapidly cool down.

[0045] 4. Dispensed into 100ml oral liquid bottles under aseptic conditions.

Embodiment 3

[0046] Example 3 Liquid Oral Rehydration Salts

[0047] prescription:

[0048] Sodium chloride 2.6g potassium chloride 1.5g sodium citrate 2.9g anhydrous glucose 13.5g strawberry flavor 2g purified water 1000ml

[0049] Preparation:

[0050] 1. Dissolve the weighed raw and auxiliary materials in 950ml of purified water, and stir to make them evenly mixed.

[0051] 2. Adjust the pH to 4.35 with phosphoric acid.

[0052] 3. Add water to the full amount of the above solution, pass it through a 0.45μm filter membrane, stir evenly, and distribute it into 100ml oral liquid bottles.

[0053] 4. Sterilize at 115°C for 30 minutes in a high-temperature and high-pressure sterilizer, and then pass through circulating water to rapidly cool down and filter.

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Abstract

The invention provides a liquid oral rehydration salt which comprises the following components in percentage by weight: 0.056-0.96% of sodium chloride, 0.034-0.042% of potassium chloride, 0.065-0.079% of sodium citrate, 0.31-0.37% of glucose and 94.5-104.5% of water. The liquid oral rehydration salt is used for treating mild and moderate dehydration caused by diarrhea and dehydration caused by children diarrhea. Through accurate control of water dosage, asepsis operation and other treatment, the high liquid oral rehydration salt is stable in quality, more convenient to use and suitable for being taken by old people and children under water shortage conditions in the open air and in case of an emergency, and can better express the efficacy.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a liquid oral rehydration salt. Background technique [0002] Oral Rehydration Salts (ORS) is recommended by the World Health Organization as a drug with excellent curative effect in the treatment of acute diarrhea and dehydration. [0003] Oral rehydration salts have gone through three stages: rehydration salts I, rehydration salts II, and rehydration salts III. Rehydration Salt I contains 3.5g sodium chloride, 2.5g potassium bicarbonate, 1.5g potassium chloride, and 20g anhydrous glucose. In 1984, it was further improved into rehydration salt II. Because sodium bicarbonate is prone to deliquescence, citron Sodium bicarbonate replaces sodium bicarbonate, which is convenient for preservation and has a better taste. [0004] Rehydration salt Ⅰ and rehydration salt Ⅱ are hypertonic solutions. The indications are only for mild dehydration caused by hydroelectric distu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/14A61K31/7004A61P1/12A61P3/12
Inventor 关屹闫冬高晓峰
Owner 北京亿灵医药科技发展有限公司
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