Application of DKK1 as diagnostic marker

A use and technology of diagnostic reagents, applied in the field of DKK1 as a diagnostic marker, can solve the problem of unclear diagnostic ability of hepatocellular carcinoma or small hepatocellular carcinoma
CN103487580AInactive Publication Date: 2014-01-01SHANGHAI INST OF ONCOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI INST OF ONCOLOGY
Publication Date
2014-01-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an application of DDK1 as a diagnostic marker. Through analysis of a large amount of hepatocellular carcinoma samples, the inventor analyzes the expressions of DKK1 and AFP, firstly discovers that serum DKK1 has a high sensitivity and specificity on diagnosis of hepatocellular carcinoma, especially diagnosis of alpha fetal protein negative hepatocellular carcinoma, identification of hepatocellular carcinoma and alpha fetal protein positive chronic liver disease, and / or diagnosis of hepatocellular carcinoma in the early stage or small hepatocellular carcinoma, and more especially the precision of clinical diagnosis can be largely increased by DKK1-AFP combined diagnosis.
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Description

technical field

[0001] The present invention belongs to the field of biomedicine; more specifically, the present invention relates to the use of DKK1 as a diagnostic marker, which can be used for: diagnosing alpha-fetoprotein-negative hepatocellular carcinoma, differentiating hepatocellular carcinoma and alpha-fetoprotein-positive chronic liver disease and / or diagnosing Early-stage hepatocellular carcinoma or small hepatocellular carcinoma. Background technique

[0002] Primary liver tumors include hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma, mixed hepatocellular carcinoma, cystadenoma of the bile duct, hepatoblastoma, hemangioma, carcinoid, lymphoma, epithelioid vascular endothelium Tumor, squamous cell carcinoma, teratoma, and leiomyosarcoma, fibrosarcoma, malignant fibrous histiocytoma, rhabdomyosarcoma and other liver sarcomas. Hepatocellular carcinoma (HCC) is one of the histological subtypes. Hepatocellular carcinoma (HCC) is one of the most commo...

Claims

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