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Anti-light aging preparation for skin

A skin photoaging and anti-photoaging technology, applied in skin care preparations, cosmetic preparations, dressing preparations, etc., to achieve the effects of improving cell activity, inhibiting ROS, and inhibiting cell aging

Inactive Publication Date: 2014-01-15
郑锦芬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no research report on the combination of AA-2G and royal jelly acid for anti-photoaging

Method used

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  • Anti-light aging preparation for skin
  • Anti-light aging preparation for skin
  • Anti-light aging preparation for skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Anti-photoaging effect of royal jelly acid (10-HDA) and AA-2G

[0039] (1) Human skin fibroblast culture

[0040] Experimental method: Take the foreskin tissue after circumcision of children, isolate and obtain purified human fibroblasts, and culture the cells in DMEM medium containing 10% fetal bovine serum (FBS) and penicillin. with 5% CO 2 cultured in a 37°C incubator.

[0041] (2) UVA irradiation

[0042] Experimental method: UVA irradiation was performed when the fibroblasts reached 80%-90% confluence. Remove the cells from the incubator, aspirate the medium, and wash twice with 37°C pre-warmed phosphate buffered saline (PBS). An equal volume of thin layers of PBS was added to each well and then irradiated with different doses of UVA. Immediately after irradiation, aspirate and discard the PBS solution, add freshly prepared normal culture medium, and place in 95% humidity, 5% CO 2 cultured in a 37°C incubator. The normal medium in this example is D...

Embodiment 2

[0076] Example 2 Anti-photoaging preparation containing royal jelly acid

[0077] Mix 10-HDA and AA-2G with stearic acid, liquid paraffin and other emulsifiers to make 10-HDA+AA-2G emulsion. Select 24 healthy adults, apply the lotion containing 10-HDA and AA-2G and the blank control (without 10-HDA and AA-2G) to two places on the inner side of the right arm, respectively, apply the lotion three times a day for 15 consecutive times Days, at the beginning of the experiment, the arm was irradiated with ultraviolet rays, once every three days, for a total of two times, and the local erythema and pigmentation were observed on the 1st, 3rd, 5th, 7th, 10th, and 15th days after irradiation.

[0078] The results showed that erythema was visible on the skin on the 1st, 3rd, 5th, and 7th days after irradiation, and the erythema area and color of the 10-HDA+AA-2G emulsion were lighter than those of the blank control. On the 10th and 15th day after irradiation, brown pigmentation can be s...

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Abstract

The invention discloses an anti-light aging preparation for the skin, wherein the preparation comprises royal jelly acid (10-HAD) and AA-2G. Meanwhile, the invention further discloses application of royal jelly acid and AA-2G in preparation of skin care products, cosmetics and cosmeceuticals. The anti-light aging preparation can substantially improve activity of cells irradiated by UVA, inhibits UVA-induced ROS generation and UVA-induced cell aging and has a substantial anti-light aging effect. According to research on action mechanism of the anti-light aging preparation, 10-HDA included in the anti-light aging preparation can inhibit activation of p-JNK and p38 MAPK signaling pathways and reduce expression of UVA-induced MMP-1 and MMP-3, so the content of collagen in cells can be increased; thus, the preparation is an effective anti-light aging preparation for the skin.

Description

technical field [0001] The present application relates to the field of anti-skin aging preparations, in particular to a new anti-skin photoaging preparation. Background technique [0002] Skin aging mainly includes endogenous aging and exogenous aging. Exogenous aging refers to the aging changes of the skin caused by environmental factors. It is also called photoaging because of the influence of ultraviolet (Ultraviolet, UV) radiation. Both long-wave ultraviolet (UVA) and medium-wave ultraviolet (UVB) can cause photoaging. Since UVB has a 1000 times stronger skin-burning effect than UVA, UVB has long been considered the main spectrum responsible for photoaging. However, recent studies have shown that UVA is the main spectrum responsible for skin photoaging. [0003] The main clinical manifestations of skin photoaging are skin wrinkling, roughness, dryness, laxity, telangiectasia, increased fragility, and hyperpigmentation. Long-term sunlight exposure can affect a variety...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/36A61Q19/08A61Q17/04
Inventor 郑锦芬
Owner 郑锦芬
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