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Blood lipid reducing composition containing phytosterol and preparation method of composition

A technology of phytosterol and composition, applied in the field of traditional Chinese medicine, can solve the problems of high price of statins, increase the economic burden of patients, gastrointestinal adverse reactions, etc. Effect

Inactive Publication Date: 2014-01-15
TIANJIN TIANSHI BIOLOGICAL DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of drug has a good effect of lowering blood lipids, but long-term use will cause muscle toxicity such as myalgia, muscle inflammation, and even rhabdomyolysis, as well as side effects such as metabolic disorders in the body, gastrointestinal adverse reactions, and liver damage.
At the same time, the price of statins is high, and long-term use will correspondingly increase the economic burden of patients

Method used

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  • Blood lipid reducing composition containing phytosterol and preparation method of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] (1) Sterol extraction

[0062] The raw material is dried, pulverized, heated with petroleum ether or / and ethyl acetate to reflux at 56°C for extraction, and the extract is concentrated under reduced pressure to obtain an extract (containing 40% solute); the resulting concentrated extract is put on a chromatography column of equal weight silica gel, First use petroleum ether: ethyl acetate=95:5 as mobile phase to obtain eluent I, then change petroleum ether: ethyl acetate=85:15 as mobile phase, flow rate 2BV / h, obtain eluent II; Deliquification II Atmospheric distillation and concentration, when concentrated to crystallization, put the liquid into the crystallization container, cool down for 2 hours, filter the crude crystal product, and recover the solvent; use petroleum ether:ethyl acetate=85:15 mixed solvent for the crude crystal product Heat to dissolve, filter, concentrate the filtrate until crystals precipitate out, put the liquid into the crystallization container...

Embodiment 2

[0067] (1) Sterol extraction

[0068] The raw materials are dried, pulverized, heated with petroleum ether or / and ethyl acetate at 70°C for reflux extraction, and the extract is concentrated under reduced pressure to obtain an extract (containing 40% solute); the resulting concentrated extract is put on a chromatography column of equal weight silica gel, First use petroleum ether: ethyl acetate=95:5 as mobile phase, obtain eluent I, then change petroleum ether: ethyl acetate=85:15 as mobile phase, flow velocity 0.2BV / h obtains eluent II; Deliquification II Atmospheric distillation and concentration, when concentrated to crystallization, put the liquid into the crystallization container, cool down for 2 hours, filter the crude crystal product, and recover the solvent; use petroleum ether:ethyl acetate=85:15 mixed solvent for the crude crystal product Heat to dissolve, filter, concentrate the filtrate until crystals precipitate out, put the liquid into the crystallization contai...

Embodiment 3

[0073] (1) Sterol extraction

[0074] The raw material is dried, pulverized, and petroleum ether or / and ethyl acetate is heated to reflux at 60°C for extraction, and the extract is concentrated under reduced pressure to obtain an extract (containing 45% solute); First use petroleum ether: ethyl acetate=95:5 as mobile phase to obtain eluent I, then change petroleum ether: ethyl acetate=85:15 as mobile phase, flow rate 2BV / h, obtain eluent II; Deliquification II Atmospheric distillation and concentration, when concentrated to crystallization, put the liquid into the crystallization container, cool down for 2 hours, filter the crude crystal product, and recover the solvent; use petroleum ether:ethyl acetate=85:15 mixed solvent for the crude crystal product Heat to dissolve, filter, concentrate the filtrate until crystals precipitate out, put the liquid into the crystallization container, cool down for 2 hours, and filter to obtain the crystallization product. After testing, the ...

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Abstract

The invention discloses a blood lipid reducing composition containing phytosterol. The composition comprises the following components by weight percent: 5-88% of total flavonoids of sea-buckthorn and 12-95% of phytosterol. The invention also discloses a preparation method of the composition. The preparation method comprises the steps of extracting active ingredients and preparing the finished product according to the formula. The traditional Chinese medicine composition makes the best of the treatment effects of active pharmaceutical ingredients on cardiovascular diseases, adopts scientific matching, generates synergistic effects, has better curative effects and more controllable quality than traditional preparations and is suitable for industrial production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] With the continuous improvement of people's living standards, changes in diet structure, population aging is becoming more and more obvious, and the incidence of coronary heart disease is increasing day by day. Coronary heart disease is a heart disease caused by narrowing of the lumen caused by coronary atherosclerosis, which causes myocardial blood supply and oxygen supply disturbance, and is known as the "world killer". As far as the whole world is concerned, coronary heart disease has become one of the most serious diseases threatening human health in the past half century, and it is the main cause of death in the United States and some industrialized countries. According to the statistics of the World Health Organization, 24....

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P3/06A61P9/00
Inventor 崔卜东贾林
Owner TIANJIN TIANSHI BIOLOGICAL DEV
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