Metronidazole expandable vaginal suppository, and preparation method and detection method thereof

A technique for vaginal expansion suppository and detection method, which is applied in the field of metronidazole vaginal expansion suppository and its preparation, can solve the problems of easily polluted clothes, difficult to clean, short effective administration time, etc., and achieve the goal of avoiding secondary infection and preventing outflow Effect

Active Publication Date: 2014-01-22
哈尔滨田美药业股份有限公司
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Xu Ziyou (Xu Ziyou, Chen Jiyue, Li Qiaoyun, etc. Experimental Research on Metronidazole Gelatin Sponge Vaginal Suppositories [J], Chinese Hospital Pharmaceutical Impurities, 1994, 14 (9): 387-388) disclosed a combination of metronidazole, gelatin, formaldehyde Sponge suppositories made of solution and distilled water; Common suppositories made of semi-synthetic fatty acid glycerides or glycerin gelatin; the water solubility of metron

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Metronidazole expandable vaginal suppository, and preparation method and detection method thereof
  • Metronidazole expandable vaginal suppository, and preparation method and detection method thereof
  • Metronidazole expandable vaginal suppository, and preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103]

[0104] Preparation:

[0105] 1) Preparation of drug-containing matrix:

[0106] a. The mixed fatty acid glycerides, hydrogenated peanut oil and lanolin are heated and melted in a water bath to obtain a melt;

[0107] b. Weigh the prescribed amount of metronidazole and pulverize, pass through a 100-mesh sieve, and mix with the melt of step a to obtain a drug-containing matrix;

[0108] 2) Pour the drug-containing matrix into the suppository mold, insert the cotton sliver, and cool and shape to make 100 cylindrical suppositories, each weighing about 3.3g.

Embodiment 2

[0110]

[0111] Preparation:

[0112] 1) Preparation of drug-containing matrix:

[0113] a. Place propylene glycol stearate, hydrogenated vegetable oil and lanolin in a water bath to heat and melt to obtain a melt;

[0114] b. Weigh the prescription amount of metronidazole, pulverize, pass through an 80-mesh sieve, and dissolve it in ethanol to obtain an ethanol solution. IRP-64 is added to the ethanol solution, mixed evenly, and dried to prepare the metronidazole resin compound;

[0115] c. Add the metronidazole resin compound of step b to step a, mix uniformly, and prepare a drug-containing matrix;

[0116] 2) Pour the drug-containing matrix into the suppository mold, insert the cotton sliver, and cool and shape to make 100 spherical suppositories, each weighing about 1.4g.

Embodiment 3

[0118]

[0119] Preparation method: According to the method in Example 2, 100 oval suppositories were made, each weighing about 3.2g.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a metronidazole expandable vaginal suppository, and a preparation method and a detection method thereof. The expandable vaginal suppository comprises metronidazole, a matrix and an expansion carrier. The drug-containing matrix also includes a resin; a resin compound formed by the resin with metronidazole can improve stability of the suppository and cooperate with an acidifier to prolong effect time of metronidazole on the vagina, extend therapeutic effect and maintain the specific acid environment and self-cleaning function of the vagina; and the chitosan can promote the absorption of metronidazole by the vagina and improve the bioavailability of the suppository. The metronidazole expandable vaginal suppository employs seven unique technologies and has beneficial effects of prevention of outflow liquid and secondary infection.

Description

Technical field [0001] The invention belongs to the field of vaginal suppositories, and particularly relates to a metronidazole vaginal expansion suppository and a preparation method and a detection method thereof. Background technique [0002] Metronidazole, whose chemical name is 2-methyl-5-nitroimidazole-1-ethanol, has the following structure: [0003] [0004] Metronidazole has poor solubility. It is slightly soluble in ethanol and slightly soluble in water. It is mainly used clinically for trichomonas vaginitis; commonly used dosage forms include oral preparations, injections and suppositories, but oral and injections, 15-30% of cases Adverse reactions dominated by the digestive tract; metronidazole suppositories are administered rectal, which overcomes the adverse reactions of oral or injection, and there is no liver first pass effect. [0005] The first edition of the Chinese Pharmacopoeia 2010 published the quality standards for metronidazole suppositories, and the 11th volu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/02A61K31/4164A61K47/36A61K47/44A61K47/34A61K47/32A61P33/02A61P15/02G01N33/15G01N30/02G01G17/00
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap