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Phenylethyl resorcinol hydroxypropyl-beta-cyclodextrin inclusion and preparation method thereof

A technology of phenylethyl resorcinol hydroxypropyl and phenylethyl resorcinol, which is applied in the field of hydroxypropyl-β-cyclodextrin inclusion complex and its preparation, and can solve the problem of poor water solubility and difficulty in direct application , low content of phenethyl resorcinol, etc., to achieve the effects of good stability, increased load content, and convenient preparation

Inactive Publication Date: 2014-01-29
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Technical problem: The purpose of the present invention is to provide a cosmetic-grade phenylethylresorcinol hydroxypropyl-β-cyclodextrin inclusion compound with high stability and high phenylethylresorcinol loading content and mild properties and The preparation method solves the problems of poor water solubility, low content of phenylethyl resorcinol and difficulty in being directly applied to cosmetics in the prior art.

Method used

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  • Phenylethyl resorcinol hydroxypropyl-beta-cyclodextrin inclusion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of phenethyl resorcinol hydroxypropyl-β-cyclodextrin inclusion compound

[0026] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0027] 1. Weigh 0.2g of phenylethyl resorcinol, dissolve in 10g of ethanol, shake and mix until clear;

[0028] 2. Then weigh 10g of hydroxypropyl-β-cyclodextrin and add it to the ethanol solution of phenylethyl resorcinol, and stir until uniform;

[0029] 3. Equilibrate in the dark for 20 minutes at 28°C;

[0030] 4. Then equilibrate at 50°C in the dark for 60 minutes;

[0031] 5. Put the above mixture into a disc, and dry it in vacuum at 60°C for 120 minutes to obtain a white loose porous solid, which is ground to powder;

[0032] 6. Store the obtained phenylethylresorcinol hydroxypropyl-β-cyclodextrin inclusion complex in a dry dish away from light, and the inclusion rate is 97.5±1.5% as determined by high performance liquid chromatography.

Embodiment 2

[0033] Example 2 Preparation of phenylethyl resorcinol hydroxypropyl-β-cyclodextrin inclusion compound

[0034] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0035] 1. Weigh 0.3g of phenylethyl resorcinol, dissolve in 10g of 1,2-propanediol, shake and mix until clear;

[0036] 2. Then weigh 12g of hydroxypropyl-β-cyclodextrin and add it to the phenylethyl resorcinol 1,2-propanediol solution, and stir until uniform;

[0037] 3. Equilibrate in the dark for 30 minutes at 28°C;

[0038] 4. Then equilibrate at 60°C in the dark for 60 minutes;

[0039] 5. Put the above mixture into a disc, and dry it in vacuum at 60°C for 60 minutes to obtain a white loose porous solid, which is ground to powder;

[0040] 6. Store the obtained phenylethylresorcinol hydroxypropyl-β-cyclodextrin inclusion complex in a dry dish away from light, and the inclusion rate is 81.8±2.9% as determined by high performance liquid chromatography.

Embodiment 3

[0041] Example 3 Preparation of phenethyl resorcinol hydroxypropyl-β-cyclodextrin inclusion compound

[0042] Such as figure 1 Shown, the preparation steps of this embodiment are as follows:

[0043] 1. Weigh 0.5g of phenylethyl resorcinol, dissolve in 10g of tert-butanol, shake and mix until clear;

[0044] 2. Then weigh 15g of hydroxypropyl-β-cyclodextrin and add it to the phenylethyl resorcinol tert-butanol solution, and stir until uniform;

[0045] 3. Equilibrate in the dark for 30 minutes at 28°C;

[0046] 4. Then equilibrate at 50°C in the dark for 100 minutes;

[0047] 5. Put the above mixture into a disc, and dry it in vacuum at 60°C for 150 minutes to obtain a white loose porous solid, which is ground to powder;

[0048] 6. Store the obtained phenylethylresorcinol hydroxypropyl-β-cyclodextrin inclusion complex in a dry dish away from light, and determine by high performance liquid chromatography that the inclusion rate is 91.6±2.1%.

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Abstract

The invention discloses a phenylethyl resorcinol hydroxypropyl-beta-cyclodextrin inclusion. The phenylethyl resorcinol hydroxypropyl-beta-cyclodextrin inclusion is characterized in that a carrier loaded is phenylethyl resorcinol. The phenylethyl resorcinol hydroxypropyl-beta-cyclodextrin inclusion has the effects of skin whitening, oxidization resisting and wrinkle resisting. A preparation method of the phenylethyl resorcinol is a vacuum drying method. The inclusion is prepared from phenylethyl resorcinol and hydroxypropyl-beta-cyclodextrin based on a molar ratio of 1: (1 to 100) by the optimized inclusion process. The inclusion is high in stability and water solubility. The preparation method is simple, controllable, and high in repeatability, and can be applied to the preparation of cosmetics containing the phenylethyl resorcinol.

Description

technical field [0001] The invention belongs to the technical field of carrier systems in cosmetic preparation technology, and relates to a hydroxypropyl-β-cyclodextrin inclusion complex loaded with an active ingredient phenylethyl resorcinol and a preparation method thereof. Background technique [0002] Phenylethylresorcinol, the chemical name is 4-(1-phenylethyl)-1,3-benzenediol, the English name is 4-(1-phenylethy)-1,3-benzenediol, and the CAS number is 85 -27-8, the molecular formula is C 14 h 14 o 2 , with a molecular weight of 214.27g / mol, a white crystalline solid with a melting point of 78-82°C. The crude product of phenylethylresorcinol can be produced from 1,3-benzenediol and styrene through Friedel-Crafts alkylation reaction, and the reaction crude product can be purified by cleaning, distillation, crystallization, etc., to obtain phenylethylresorcinol phenol. Phenylethyl resorcinol is an excellent whitening agent and antioxidant, and one of the most effecti...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K8/33A61Q19/02A61Q19/00
Inventor 夏强范恒锋
Owner SOUTHEAST UNIV
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