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A kind of preparation method of calcium metaphosphate porous bioceramics

A calcium metaphosphate, bioceramic technology, applied in ceramic products, applications, medical science and other directions, can solve the problem that the porous ceramic method has not been reported.

Inactive Publication Date: 2016-03-30
NANJING TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there is no report on the preparation of porous ceramics by the in-situ self-foaming method.

Method used

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  • A kind of preparation method of calcium metaphosphate porous bioceramics
  • A kind of preparation method of calcium metaphosphate porous bioceramics
  • A kind of preparation method of calcium metaphosphate porous bioceramics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Step 1: Ca(H 2 PO 4 ) 2 ·H 2 Preparation of O(MCPM) Precursors

[0034] 42.06 g of calcium oxide with a Ca / Pmol ratio of 0.5 was added to 500.0 ml of phosphoric acid solution with a concentration of 3.0 mol, and the solution was stirred with a magnetic stirrer for 48 hours to precipitate, and the precipitate was placed in an electric heating constant temperature blast drying oven at 60°C It is dried under low pressure and the dried powder is pulverized to 50 μm or less. That is to get Ca(H 2 PO 4 ) 2 ·H 2 O(MCPM) precursor powder. Product Ca(H 2 PO 4 ) 2 ·H 2 The X-ray diffraction pattern of O(MCPM) powder is attached to the specification figure 1 shown.

[0035] Step 2: Preparation of calcium metaphosphate porous ceramics

[0036] Take 5g of the above synthesized Ca(H 2 PO 4 ) 2 ·H 2 O(MCPM) and 4wt% of PVA binder were mixed uniformly, granulated and sieved, and formed by dry pressing under 2Mpa pressure, then heated to 500°C at a heating rate of 0.5...

Embodiment 2

[0038] Step 1: Ca(H 2 PO 4 ) 2 ·H 2 Preparation of O(MCPM) Precursors

[0039] 14.02 g of calcium oxide with a Ca / Pmol ratio of 0.5 was added to 500.0 ml of phosphoric acid solution with a concentration of 1.0 mol. The solution was stirred with a magnetic stirrer for 36 hours and then precipitated. It is dried under low temperature and the dried powder is pulverized to 60 μm or less. That is to get Ca(H 2 PO 4 ) 2 ·H 2 O(MCPM) precursor powder. Product Ca(H 2 PO 4 ) 2 ·H 2 The X-ray diffraction pattern of O(MCPM) powder is attached to the specification figure 1 shown.

[0040] Step 2: Preparation of calcium metaphosphate porous ceramics

[0041] Take a certain amount of the above synthesized Ca(H 2 PO 4 ) 2 ·H 2 O(MCPM) was thermally treated at 140 °C for 1 hour to prepare Ca(H 2 PO 4 ) 2 (MCPA) powder. Take 5gCa (H 2 PO 4 ) 2 (MCPA) powder was mixed with 5wt% PVA binder uniformly, granulated and sieved, and formed under 2Mpa pressure by dry pressing ...

Embodiment 3

[0043] Step 1: Ca(H 2 PO 4 ) 2 ·H 2 Preparation of O(MCPM) Precursors

[0044] 28.04 g of calcium oxide with a Ca / Pmol ratio of 0.5 was added to 500.0 ml of phosphoric acid solution with a concentration of 2.0 mol, and the solution was stirred with a magnetic stirrer for 60 hours to precipitate, and the precipitate was placed in an electric heating constant temperature blast drying oven at 55°C The dried powder was pulverized to 70 μm or less. That is to get Ca(H 2 PO 4 ) 2 ·H 2 O(MCPM) precursor powder. Product Ca(H 2 PO 4 ) 2 ·H 2 The X-ray diffraction pattern of O(MCPM) powder is attached to the specification figure 1 shown.

[0045] Step 2: Preparation of calcium metaphosphate porous ceramics

[0046] Take a certain amount of the above synthesized Ca(H 2 PO 4 ) 2 ·H 2 O(MCPM) was thermally treated at 250 °C for 0.5 h to prepare CaH 2 P 2 O 7 (CDPP) powder. Take 5gCaH 2 P 2 O 7 (CDPP) powder and 4.5wt% PVA binder are mixed uniformly, granulated and...

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Abstract

The invention relates to a preparation method of calcium metaphosphate porous bioceramic. The preparation method is characterized by using calcium oxide and phosphoric acid as initial reactants to synthesize monocalcium phosphate monohydrate (Ca(H2PO4)2.H2O, MCPM) powder by means of isothermal crystallization chemical precipitation according to the formation mechanism of calcium metaphosphate; carrying out thermal treatment on the powder at different temperatures respectively to synthesize monocalcium phosphate (Ca(H2PO4)2, MCPA) powder and calcium dihydrogen pyrophosphate (CaH2P2O7, CDPP) powder; preparing the calcium metaphosphate porous ceramic from the powder synthesized respectively in the condition of controlling the molding process and the sintering mechanism (such as the molding pressure of the sample, and the temperature raising rate of the initial thermal treatment). The gas released when different crystal water contained in the raw material is decomposed is used as a pore forming agent, and the synthesis method of the powder and the preparation process of the porous body are controlled to obtain the calcium metaphosphate porous ceramic prepared by adopting the preparation method disclosed by the invention.

Description

technical field [0001] The invention relates to a preparation method of calcium metaphosphate porous bioceramics. technical background [0002] At present, biomaterials mainly include four types of medical metal materials, ceramic materials, medical polymer materials and their composite materials. Metal materials have high strength and are easy to process into complex shapes. Common medical metal materials include cobalt-chromium alloys, titanium alloys, and stainless steel. Medical polymer materials are easily degradable, including naturally derived chitosan, collagen, various proteins and synthetic polylactic acid, polyethylene, polypropylene and other polymers. Ceramic materials have both properties and are often used as orthopedic implants and dental materials, typically represented by alumina, calcium phosphate and bioglass. [0003] Calcium metaphosphate (CMP) has the advantages of excellent biocompatibility, bioactivity, biodegradability, osteoconductivity and osteo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12C04B38/00C04B35/622C04B35/447
Inventor 张垠姚能健
Owner NANJING TECH UNIV