Astragalus extractive grading preparation method

An astragalus extract and an astragalus extract technology are applied in the field of preparing the astragalus extract by using subcritical fluid classification, which can solve the problems of high manufacturing and operating costs, difficult industrial mass production, large ethanol consumption and the like, and achieves simplified production process, The effect of less impurities and lower production cost

Active Publication Date: 2014-02-05
JING BRAND
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Problems solved by technology

[0010] The purpose of the present invention is exactly to exist the shortcoming such as long production period, higher energy consumption, large ethanol consumption, high labor cost of existing traditional method for preparing Radix Astragali extract, and supercritical fluid extraction method and ultrasonic extraction method have equipment manufacture and The problem of high operating costs and difficulty in realizing large-scale industrial production provides a high-efficiency, energy-saving and environmentally-friendly method for preparing astragalus extracts using subcritical extraction technology; at the same time, the present invention also provides a method for large-scale production of astragalus with different contents. The method of extraction provides favorable conditions for vigorously promoting the expansion of the medical use of Astragalus extract and the development of new drugs.

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  • Astragalus extractive grading preparation method

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Effect test

Embodiment 1

[0059] (1) Raw material treatment: take 100kg of dried Astragalus medicinal material, detect that the content of astragaloside IV is 0.4%, crush it into 30-60 mesh coarse powder, put it into a 100-mesh filter bag, and then put the filter bag into subcritical In the material column of the extraction kettle;

[0060] (2) Raw material infiltration: Add 50L of edible alcohol with a volume fraction ≥ 95% in the extraction kettle as an entrainer, and infiltrate for 30 minutes at a temperature of 30°C;

[0061] (3) Subcritical extraction: Add 500L 1,1,1,2-tetrafluoroethane into the extraction kettle as the extraction agent, extract for 30 minutes at a pressure of 1Mpa and a temperature of 40°C, and put the extract into the separation kettle In the process, under the pressure of 0.04Mpa, the extractant is evaporated and recovered for mechanical use, and the remaining liquid is the Astragalus extract; the above extraction process is repeated 4 times, and the Astragalus extract is combi...

Embodiment 2

[0078] (1) Raw material treatment: Take 100kg of dried Astragalus medicinal material, detect that the content of astragaloside IV is 0.4%, grind it into coarse powder of 10-60 mesh, put it into a 100-mesh filter bag, and then put the filter bag into subcritical In the material column of the extraction kettle;

[0079] (2) Raw material infiltration: Add 20L of edible alcohol with a volume fraction ≥ 95% in the extraction kettle as an entrainer, and infiltrate at a temperature of 50°C for 60 minutes;

[0080] (3) Subcritical extraction: Add 600L 1,1,1,2-tetrafluoroethane into the extraction kettle as the extractant, extract for 40 minutes at a pressure of 1.2Mpa and a temperature of 40°C, and put the extract into the separation In the kettle, under the pressure of 0.04Mpa, the extractant was evaporated and recovered for mechanical use, and the remaining liquid was the Astragalus extract; the above extraction process was repeated 3 times, and the Astragalus extract was combined e...

Embodiment 3

[0095] (1) Raw material treatment: Take 100kg of dried Astragalus medicinal material, detect that the content of astragaloside IV is 0.4%, grind it into coarse powder of 10-60 mesh, put it into a 100-mesh filter bag, and then put the filter bag into subcritical In the material column of the extraction kettle;

[0096] (2) Raw material infiltration: add 150L of edible alcohol with a volume fraction ≥ 95% in the extraction kettle as an entrainer, and infiltrate at a temperature of 30°C for 20 minutes;

[0097] (3) Subcritical extraction: add 400L 1,1,1,2-tetrafluoroethane into the extraction kettle as the extraction agent, extract for 40 minutes at a pressure of 0.8Mpa and a temperature of 40°C, and put the extract into the separation In the kettle, under the pressure of 0.08Mpa, the extractant is evaporated and recovered for mechanical use, and the remaining liquid is the extract of Astragalus; repeat the above extraction process 5 times, and combine the extract of Astragalus e...

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Abstract

The invention discloses an astragalus extractive grading preparation method. The astragalus extractive grading preparation method comprises the following steps: smashing an astragalus medicinal material, then loading in a filter bag, and putting the filter bag in a subcritical extraction kettle; soaking for 10-60 minutes by using 95% edible alcohol at the temperature of 20-50 DEG C; then adding 1, 1, 1, 2-tetrafluoroethane serving as an extraction agent to the extraction kettle, extracting for 20-60 minutes under the conditions that the pressure is 0.3-1.6Mpa, and the temperature is 20-60 DEGC, putting extract liquor in a separation kettle, and evaporating and recycling the extraction agent, wherein raffinate is an astragalus extract solution; repeating the extraction process two times to six times, combining each astragalus extract solution, and concentrating the astragalus extract solution under reduced pressure so as to obtain the astragalus extractives different in astragaloside content. According to the astragalus extractive grading preparation method, the astragalus extractives are extracted by adopting subcritical fluid R134a under the subcritical condition. Compared with a conventional production method, the astragalus extractive grading preparation method has the advantages of high extraction rate, environmental friendliness, short production cycle and well market adaptability and can be used for producing the astragalus extractives of different levels at low cost on a large scale.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine extract, in particular to a method for preparing astragalus extract by subcritical fluid classification. Background technique [0002] Astragalus membranaceus (Qi) is known as "the best of all qi-tonifying medicines". It is a rare and precious Chinese herbal medicine, and it is also the most commonly used Chinese herbal medicine. The Astragalus membranaceus recorded in "Chinese Pharmacopoeia" is the dried root of the leguminous plant Astragalus mongolica or Astragalus membranaceus. Astragalus membranaceus is mild in nature, sweet in taste, and has the effects of invigorating qi and solidifying the surface, antiperspirant and detoxification, promoting muscle growth, diuresis, and reducing swelling. It is used to treat qi deficiency and fatigue, depression of middle qi, chronic diarrhea and prolapse of the anus, bloody stool and metrorrhagia, surface deficiency and spontaneo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61K31/7048C07J53/00
Inventor 闪媛媛胡力飞陈志元胡辉杨跃军
Owner JING BRAND
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