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Bacterial cellulose/chitosan composite sponge dressing and preparation method thereof

A bacterial cellulose and composite sponge technology, applied in dressings, viscous dressings, medical science and other directions, can solve the problems of limited liquid absorption capacity, easy deformation, insufficient strength, etc., and achieves strong shape maintenance ability, high tensile strength, and preparation Simple process effect

Active Publication Date: 2014-02-05
湖南仁馨生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the strength of chitosan nonwoven dressing is not enough, it is easily deformed, and its liquid absorption capacity is limited.

Method used

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  • Bacterial cellulose/chitosan composite sponge dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The bacterial cellulose membrane with a degree of polymerization of 800 was boiled with 1% NaOH aqueous solution at 80 °C for 45 min, then fully washed with distilled water until neutral (pH=7.0), and vacuum-dried at 75 °C for 12 h. Use a ball mill to grind to a length of 6.5mm and a specific surface area of ​​500m 2 / g of fibrids.

[0031] Chitosan sheet is placed in 2% (mass fraction) acetic acid, let stand for more than 4 hours, then add glacial acetic acid and make wherein acetic acid content reaches 4%, be dubbed as the shell that content is 3% (mass fraction) through stirring polysaccharide solution. The bacterial cellulose fibrids are added to the chitosan solution in an amount of 15% of the dry weight of the chitosan, and left to stand for defoaming.

[0032] The above-mentioned chitosan solution added with bacterial cellulose fibrids was poured into a flat-bottomed shallow dish, frozen in a refrigerator at -20°C for 7-9 hours, and then freeze-dried to obtain ...

Embodiment 2

[0035] The bacterial cellulose membrane with a degree of polymerization of 1000 was boiled with 1% NaOH aqueous solution at 80 °C for 45 min, then washed with distilled water until neutral (pH = 7.0), and vacuum-dried at 75 °C for 12 h. Use a ball mill to grind to a length of 5.5mm and a specific surface area of ​​600m 2 / g of fibrids.

[0036] The chitosan sheet was placed in 3% (mass fraction) acetic acid, left to stand for more than 4 hours, and then stirred to form a chitosan solution with a content of 3% (mass fraction). The bacterial cellulose fibrids are added to the chitosan solution in an amount of 10% of the dry weight of the chitosan, and left standing for defoaming.

[0037] The above-mentioned chitosan solution added with bacterial cellulose fibrids was poured into a flat-bottomed shallow dish, frozen in a refrigerator at -20°C for 7-9 hours, and then freeze-dried to obtain a bacterial cellulose / chitosan composite sponge.

[0038] The bacterial cellulose / chitosa...

Embodiment 3

[0040] The bacterial cellulose membrane with a degree of polymerization of 3000 was boiled with 1% NaOH aqueous solution at 80 °C for 45 min, then washed with distilled water until neutral (pH = 7.0), and vacuum-dried at 75 °C for 12 h. Use a ball mill to grind to a length of 9.5mm and a specific surface area of ​​400m 2 / g of fibrids.

[0041] Chitosan tablets were placed in 1-butyl-3-methylimidazolium chloride [C 4 In MIM]Cl, let stand more than 8 hours, be made into the chitosan solution that content is 9% (mass fraction) through stirring. The bacterial cellulose fibrids are added to the chitosan solution in an amount of 20% of the dry weight of the chitosan, and left to stand for defoaming.

[0042] The above-mentioned chitosan solution added with bacterial cellulose fibrids was poured into a flat-bottomed shallow dish, frozen in a refrigerator at -20°C for 7-9 hours, and then freeze-dried to obtain a bacterial cellulose / chitosan composite sponge.

[0043] The bacterial c...

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Abstract

The invention relates to a bacterial cellulose / chitosan composite sponge dressing and preparation method thereof. The dressing comprises a cellulose / chitosan composite sponge layer (1), an adhering layer (2) and a nonwoven fabric layer (3) which are placed from top to bottom in sequence. The preparation method comprises the following steps of (1) boiling a bacterial cellulose membrane with an NaOH aqueous solution, fully washing with distilled water to reach neutral state, and then drying in vacuum to obtain bacterial cellulose fibrid; (2) preparing a chitosan solution, adding the bacterial cellulose fibrid, standing and defoaming, freezing, and finally freezing and drying to obtain bacterial cellulose / chitosan composite sponge; and (3) adhering the bacterial cellulose / chitosan composite sponge to a polypropylene nonwoven fabric with permeable micropores through an adhesive, a hot melt adhesive or a thermosensitive adhesive, thus obtaining the bacterial cellulose / chitosan composite sponge dressing. The dressing has the effects of stopping bleeding, diminishing inflammation, sterilizing, promoteing the wound healing, and has the advantages of no scar, high tensile strength, high water binding capacity and air and water permeability, high shape maintaining ability, etc. The preparation method is simple.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to a bacterial cellulose / chitosan composite sponge dressing and a preparation method thereof. Background technique [0002] Medical dressings are materials used to treat wounds. In the case of minor burns (first and second degree), the wound site is usually covered with a medical dressing to inhibit the evaporation of body fluids and prevent the invasion of bacteria. In case of severe burns (third degree), artificial skin should be used. [0003] Ordinary medical dressings are usually composed of 3 layers: contact wound layer, absorbent layer and matrix material layer; wound dressings cannot adhere to the wound, and should be removed easily without damaging new tissue growth. The middle layer absorbs blood and water, acts as a septum layer on the wound, and protects the wound. The layer of base material is coated with adhesive to hold the dressing in place. [0004] The main fun...

Claims

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Application Information

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IPC IPC(8): A61L15/36A61L15/28A61L15/44A61F13/02
Inventor 沈新元杨昌顺
Owner 湖南仁馨生物技术有限公司
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