Preparation method of soluble calcium citrate

A technology of calcium citrate and citric acid, which is applied in the field of biochemical medicine and food, and can solve the problems of limited use, insoluble in water, and difficult absorption by humans and animals

Inactive Publication Date: 2014-02-05
李玉成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In today's biochemical, pharmaceutical and food markets at home and abroad, calcium citrate is a commonly used food additive for calcium supplementation and bone strengthening and a medicine for treating osteoporosis, leg cramps, and osteochondrosis. Its English name: Calcium citrate, molecular formula: Ca 3 (C 6 h 5 o 7 ) 2 4H 2 O, molecular weight: 570.52, calcium content 21.08%, citric acid 66.30%, crystal water 12.62%, purity above 98.0-100.5% (medicine and food grade), it is white crystalline powder, hardly soluble in water, at 25 0.095gCa / 100ml and 0.45gCa at ℃ 3 (C 6 h 5 o 7 ) 2 4H 2 The dissolved amount of O / 100ml is not easily absorbed by humans and animals, and its use is limited

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  • Preparation method of soluble calcium citrate

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Effect test

Embodiment 1

[0021] The preparation method of the present embodiment soluble calcium citrate comprises the following steps:

[0022] (1) Weigh 420.28g of citric acid monohydrate, 222.24g of calcium hydroxide and a certain amount of water, and put the raw materials into the reaction kettle together;

[0023] (2) Start the chemical reaction for half an hour, the chemical reaction formula is:

[0024] 2C 6 h 8 o 7 ·H 2 O+3Ca(OH) 2 = Ca 3 (C 6 h 5 o 7 ) 2 4H 2 O↓+4H 2 0, the reaction temperature is normal temperature;

[0025] (3) Shut down for half an hour, add ethanol to make the chemical reaction mature, and precipitate easily soluble calcium citrate crystals;

[0026] (4) Start the machine for half an hour, then filter and wash the materials in the reactor after the reaction to obtain soluble calcium citrate crystals.

[0027] (5) After drying, 570.52g of soluble calcium citrate was obtained, and the finished product was packaged.

Embodiment 2

[0029] The preparation method of the present embodiment soluble calcium citrate comprises the following steps:

[0030] (1) Weigh 840.56g of citric acid monohydrate, 444.48g of calcium hydroxide and a certain amount of water, and put the raw materials into the reaction kettle together;

[0031] (2) Start the chemical reaction for half an hour, the chemical reaction formula is:

[0032] 2C 6 h 8 o 7 ·H 2 O+3Ca(OH) 2 = Ca 3 (C 6 h 5 o 7 ) 2 4H 2 O↓+4H 2 0, the reaction temperature is normal temperature;

[0033] (3) Shut down for half an hour, add ethanol to make the chemical reaction mature, and precipitate easily soluble calcium citrate crystals;

[0034] (4) Start the machine for half an hour, then filter and wash the materials in the reactor after the reaction to obtain soluble calcium citrate crystals.

[0035] (5) After drying, 1141.04g of soluble calcium citrate was obtained, and the finished product was packaged.

Embodiment 3

[0037] Weigh 3.7 g of the easily soluble calcium citrate prepared in Example 1, add 100 ml of water, and stir at room temperature for 5 minutes to completely dissolve.

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Abstract

The invention relates to a preparation method of soluble calcium citrate. The preparation method of the soluble calcium citrate is characterized by comprising the following steps: (1) weighing raw materials, namely citric acid monohydrate, calcium hydroxide and water to feed to a reaction kettle, wherein the mass ratio of the citric acid monohydrate to the calcium hydroxide is 2:3; (2) starting up to carry out chemical reaction for half an hour; (3) shutting down for half an hour, and adding ethanol, so that the chemical reaction becomes mature; (4) starting up for half an hour, and discharging the soluble calcium citrate. The calcium citrate prepared by the method contains soluble calcium, so that the calcium citrate can be more easily absorbed by people and animals, and is a food additive for supplementing calcium and strengthening the bone, and a drug for treating osteoporosis, cramp in the leg and chondropathy. The soluble calcium citrate also can be used for preparing a soluble calcium citrate injection and a soluble calcium citrate oral liquid. The application range of the soluble calcium citrate greatly exceeds that of insoluble calcium citrate.

Description

technical field [0001] The invention relates to the field of biochemical medicine and food, in particular to a preparation method of easily soluble calcium citrate. Background technique [0002] In today's biochemical, pharmaceutical and food markets at home and abroad, calcium citrate is a commonly used food additive for calcium supplementation and bone strengthening and a medicine for treating osteoporosis, leg cramps, and osteochondrosis. Its English name: Calcium citrate, molecular formula: Ca 3 (C 6 h 5 o 7 ) 2 4H 2 O, molecular weight: 570.52, calcium content 21.08%, citric acid 66.30%, crystal water 12.62%, purity above 98.0-100.5% (medicine and food grade), it is white crystalline powder, hardly soluble in water, at 25 0.095gCa / 100ml and 0.45gCa at ℃ 3 (C 6 h 5 o 7 ) 2 4H 2 The dissolved amount of O / 100ml is not easily absorbed by humans and animals, and its use is limited. Contents of the invention [0003] The purpose of the present invention is to ad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C59/265C07C51/41
CPCC07C51/412C07C59/265
Inventor 李玉成
Owner 李玉成
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