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Preparation method of hexa-vitamin phosphatide soft capsule

A technology of six-dimensional phospholipids and soft capsules is applied in the directions of capsule delivery, medical preparations containing active ingredients, pharmaceutical formulations, etc. High stability and improved use effect

Active Publication Date: 2014-02-19
黑龙江澳利达奈德制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] For this reason, the technical problem to be solved by the present invention is that after the long-term storage of the six-dimensional phospholipid soft capsule, the contents are prone to stratification and inhomogeneity. capsule method

Method used

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  • Preparation method of hexa-vitamin phosphatide soft capsule
  • Preparation method of hexa-vitamin phosphatide soft capsule
  • Preparation method of hexa-vitamin phosphatide soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0168] The preparation method of the six-dimensional phospholipid soft capsule comprises the steps:

[0169] (1) Take soybean lecithin powder 18kg, nicotinamide 1.8kg, vitamin B 1 360g, vitamin B 2 360g, vitamin B 6 360g, vitamin B 12 0.36g, vitamin E360g, auxiliary material soybean oil 20.52kg, the bulk medicine after weighing except soybean lecithin and soybean oil, other raw medicines are respectively passed through 100 mesh sieves;

[0170] (2) Take 16.8kg of soybean oil and place it in the batching tank, first add soybean lecithin powder, and carry out colloid mill grinding treatment. Grind twice, then add 0.24kg of silicone oil, soak and stir for 12 hours, cool to room temperature, stir well and then add vitamin B after mixing 12 , Niacinamide, Vitamin B 1 , Vitamin B 2 with vitamin B 6 , stirring and mixing, stirring and mixing with the rotating speed of 80r / min; Get the described soybean oil of 1.2kg and the beeswax of 0.6kg, after heating and melting, add the s...

Embodiment 2

[0179] The preparation method of described six-dimensional phospholipid soft capsule comprises the steps:

[0180] (1) Take soybean lecithin powder 360g, nicotinamide 1.8kg, vitamin B 1 360g, vitamin B 2 360g, vitamin B 6 360g, vitamin B 12 0.36g, vitamin E 360g, auxiliary material soybean oil 1.8kg, except soybean lecithin and soybean oil, other raw materials were passed through a 50-mesh sieve after weighing the raw materials;

[0181] (2) Take soybean oil accounting for 75% of the total amount and put it in the batching tank, first add soybean lecithin powder, stir evenly, then carry out colloid mill grinding treatment, first adjust the colloid mill to the coarsest, grind twice, and then grind the colloid Grind to the finest, grind once, then add 0.0036kg of silicone oil, soak and stir for 14 hours, cool to room temperature, then add the mixed vitamin B 12 , Niacinamide, Vitamin B 1 , Vitamin B 2 with vitamin B 6 , stirring and mixing, stirring and mixing with the ro...

Embodiment 3

[0190] The preparation method of described six-dimensional phospholipid soft capsule comprises the steps:

[0191] (1) Take soybean lecithin powder 36kg, nicotinamide 1.8kg, vitamin B 1 360g, vitamin B 2 360g, vitamin B 6 360g, vitamin B 12 0.36g, vitamin E360g, auxiliary material soybean oil 21.6kg, except soybean lecithin and soybean oil, other raw materials were passed through a 200-mesh sieve for the raw materials after weighing;

[0192] (2) Take soybean oil accounting for 85% of the total amount and place it in the batching tank, first add soybean lecithin powder, stir well, then carry out colloid mill grinding treatment, first adjust the colloid mill to the coarsest, pass grinding once, and then put Adjust the colloid mill to the finest, grind once, then add 0.54kg of silicone oil, soak and stir for 13 hours, cool to room temperature, and then add the mixed vitamin B 12 , Niacinamide, Vitamin B 1 , Vitamin B 2 with vitamin B 6 , stirring and mixing, stirring and ...

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Abstract

The invention discloses a preparation method of a hexa-vitamin phosphatide soft capsule, and the preparation method comprises the following steps: taking bulk drugs comprising 1-100 parts of soybean phosphatide powder, 5-120 parts of soybean oil, 2-8 parts of niacinamide, 0.5-2 parts of vitamin B1, 0.5-2 parts of vitamin B2, 0.5-2 parts of vitamin B6, 0.5-2*10<-3> part of vitamin B12 and 0.5-2 parts of vitamin E for standby use; adding the bulk drugs in a certain order, and evenly mixing; performing milling treatment on the mixed drug liquid by a colloid mill, adding the vitamin E with stirring, evenly mixing to obtain required a material-containing drug liquid; taking the material-containing drug liquid to prepare the hexa-vitamin phosphatide soft capsule by a routine technology. According to the preparation method, the bulk drugs use the soybean phosphatide powder and the soybean oil as raw materials to replace liquid phosphatide in the prior art as a raw material to prepare the hexa-vitamin phosphatide soft capsule, and the obtained hexa-vitamin phosphatide soft capsule is more homogeneous and non-layering, and has a substantial effect of good long-term stability.

Description

technical field [0001] The invention relates to a preparation method of medicines and nutraceuticals, in particular to a preparation method of six-dimensional phospholipid soft capsules. Background technique [0002] Soy lecithin products are listed as safe and multi-purpose natural food additives by countries all over the world. In medicine and health care products, phospholipids, as an important feature of natural substances, have been further valued. It can be used as an active ingredient to treat a variety of diseases, and can also be used as a conditioner and emulsifier for the preparation of various pharmaceutical preparations. Phospholipids can also be used The property of forming liposomes is used in the delivery or delivery system of pharmaceuticals. The importance of phospholipids to human health and disease prevention is mainly to treat and protect the nervous system, cardiovascular system, immune system and storage and delivery of lipid organs, such as arteriosc...

Claims

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Application Information

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IPC IPC(8): A61K31/714A61K47/44A61K9/48A61P3/02A61K31/685A61K31/525A61K31/51A61K31/455A61K31/4415A61K31/355
Inventor 周有财
Owner 黑龙江澳利达奈德制药有限公司
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