Micro-reactor suitable for micro-liquid mixing and biochemical reaction and manufacturing method thereof

Abstract

The invention discloses a micro-reactor suitable for micro-liquid mixing and biochemical reaction and a manufacturing method thereof. The micro-reactor comprises an upper cover plate and a lower base plate which is butted with the upper cover plate. A piezoelectric film is arranged between the lower base plate and the upper cover plate. The piezoelectric film is provided with a micro channel, an outlet and an inlet of which are respectively corresponding to a liquid outlet and a liquid inlet of the upper cover plate. A surface acoustic wave generator is also arranged between the lower base plate and the piezoelectric film. According to the invention, a temperature control system is integrated into the micro-reactor such that a reaction in the micro-reactor can be conducted under the condition of constant temperature. By the mechanism of surface acoustic wave, mechanical vibration can be generated to drive non-charged liquids to be mixed, and an alternating electric field also will be generated on an energy transducer. Thus, the micro-reactor is endowed with a liquid vibration function by surface acoustic wave, a liquid driving function by the alternating electric field and a microenvironment temperature control function, and efficiency of a micro-liquid chemiluminiscence reaction can be raised greatly. Therefore, the structure also has a wider application range, and will have a more obvious effect of driving charged liquids.

Description

technical field [0001] The invention belongs to the field of liquid reactors, and in particular relates to a microreactor suitable for micro-liquid mixed biochemical reactions and a manufacturing method thereof. Background technique [0002] The application of micro-nano manufacturing technology integrates the mixing, reaction, and detection functions of chemical samples in a small volume to form a microfluidic laboratory, which can realize the miniaturization and low cost of biochemical detection systems. Microfluidic chip laboratory, also known as chip laboratory, integrates sample preparation, reaction, separation, detection, cell culture, separation, lysis and other operations involved in the fields of chemistry and biology into the chip. In a microfluidic chip, the substances we care about and manipulate usually exist in the form of liquid (pure liquid solution or suspension, etc.). For the research of biology, chemistry and related disciplines, purposeful control The ...

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Problems solved by technology

However, these devices can only be applied to charged fluids, and the requirements for fluids are relatively high

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