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Acotiamide sustained-release preparation

A technology of acotiamide and sustained-release preparations, which is applied in the field of medicine and can solve problems such as difficulty in adapting to patients

Inactive Publication Date: 2014-03-05
BEIJING KANG LISHENG PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is difficult for patients who often travel or have business entertainment

Method used

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  • Acotiamide sustained-release preparation
  • Acotiamide sustained-release preparation
  • Acotiamide sustained-release preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: the preparation of acotiamide sustained-release tablet

[0031]

[0032] Preparation process: pass the main drug and auxiliary materials through a 100-mesh sieve. Mix the main drug in the immediate-release part and the auxiliary materials except magnesium stearate evenly, make soft material with 70% ethanol, granulate with 16 mesh, dry at 60°C, granulate with 16 mesh, and add magnesium stearate as the instant release part. Release part of the granules; mix the main drug in the slow-release part and the excipients except magnesium stearate evenly, make soft material with 70% ethanol, granulate with 16 mesh, dry at 50°C, granulate with 16 mesh, add stearin Magnesium sulfate was used as the extended-release part of the granules; the bilayer sustained-release tablets of acotiamide were prepared on a bilayer tablet press.

Embodiment 2

[0033] Embodiment 2: the preparation of acotiamide sustained-release tablet

[0034]

[0035] Preparation process: pass the main drug and auxiliary materials through a 100-mesh sieve. Mix the main drug in the slow-release part and the excipients except magnesium stearate evenly, make soft material with 70% ethanol, granulate with 16 mesh, dry at 50°C, granulate with 16 mesh, add magnesium stearate and press into tablets As the sustained-release part; the hypromellose in the immediate-release part is made into a 5% aqueous solution, the main drug is added and suspended evenly, and the immediate-release part is wrapped on the sustained-release part by coating equipment.

Embodiment 3

[0036] Embodiment 3: the preparation of acotiamide sustained-release tablet

[0037]

[0038] Preparation process: pass the main drug and auxiliary materials through a 100-mesh sieve. Mix the main drug in the slow-release part and the excipients except magnesium stearate evenly, make soft material with 70% ethanol, granulate with 16 mesh, dry at 50°C, granulate with 16 mesh, add magnesium stearate and press into tablets As the sustained-release part; the hypromellose in the immediate-release part is made into a 5% aqueous solution, the main drug is added and suspended evenly, and the immediate-release part is wrapped on the sustained-release part by coating equipment.

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Abstract

The invention provides an acotiamide sustained-release preparation. An acotiamide sustained-release part contains at least one high molecular polymer which is a sustained-release framework material, preferably hydroxypropyl methyl cellulose, methyl cellulose, hydroxypropyl cellulose, polyethylene oxide, hydroxyethyl cellulose, polyvinyl alcohol, polyvinyl pyrrolidone, acrylic acid copolymer and the like.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a sustained-release preparation of acotiamide. Background technique [0002] Acotiamide Hydrochloride belongs to aminothiazole derivatives, [0003] The chemical name of acotiamide is N-{2-[bis(1-methylethyl)amino]ethyl}-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino] Thiazole-4-carboxamide hydrochloride. English chemical name: 2-[Bis(1-methylethyl)amino]ethyl}-2-[(2-hydroxy-4,5-dimethoxybenzoy)amino]thiazo le-4-carboxamide monohydrochlor ide; molecular formula: C 21 h 30 N40 5 S HCl 3H 2 O; Molecular weight: 541.06; CAS registration number: 773092-05-0, functional dyspepsia (FD) jointly developed by Japan Angstless Pharmaceutical Company and Zeria Pharmaceuticals Co., Ltd (Zeria New Drug Co., Ltd.) ) treatment drug, the trade name is Acofide, which was first launched in Japan on June 3, 2013. [0004] The dosage of the existing acotiamide preparation is three times a day, 100 mg each ti...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/52A61K31/426A61P1/14
Inventor 程刚
Owner BEIJING KANG LISHENG PHARMA TECH DEV