Preparation method of iron sucrose bulk drug and injection

A technology of ferric sucrose and raw materials, which is applied in the preparation of sugar derivatives, pharmaceutical formulations, chemical instruments and methods, etc., can solve the problems of immunity and destruction, cell carcinogenesis, etc., and achieves weight gain, high water solubility, and easy control of the reaction process. Effect

Inactive Publication Date: 2014-03-12
TIANJIN ZHONGAO BIOTECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And ferric iron has a strong oxidative property, which has certa

Method used

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  • Preparation method of iron sucrose bulk drug and injection
  • Preparation method of iron sucrose bulk drug and injection
  • Preparation method of iron sucrose bulk drug and injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A preparation method of iron sucrose bulk drug, the steps are:

[0016] (1) Iron salt alkalization: dissolve 1-10 parts of iron salt and 1-10 parts of stabilizer in 10-40 parts of distilled water, and add 1-10 parts of 10%-40% alkali solution at 10-30 °C , adjust the pH value to 3-5, filter out the reddish-brown precipitate, and put it into 10-40 parts of distilled water for later use.

[0017] (2) Alkalinization: Dissolve 1-10 parts of sucrose in 10-30 parts of distilled water, add 1-40 parts of 10%-30% lye, and stir at 80°C-120°C for 1-4 hours.

[0018] (3) Complexation: After the reaction in step (2) is completed, add the stock solution obtained in step (1) to the solution obtained in step (2), and react at 80-120° C. for 1-3 hours under stirring. The pH of the system is always kept at 3-6. When the reaction is over, use 10%-30% alkali solution to adjust the pH of the system to 5-8 to complete the complexation.

[0019] (4) Alcohol precipitation: when the complex s...

Embodiment 2

[0023] A preparation method of iron sucrose bulk drug, the steps are:

[0024] (1) Iron salt alkalization: dissolve 100kg iron salt and 10kg stabilizer in 400kg distilled water, add 100kg of 40% alkali solution at 30°C, adjust the pH value to 5, filter out the reddish-brown precipitate produced, and put Put into 400kg distilled water for subsequent use.

[0025] (2) Alkalinization: Dissolve 100 kg of sucrose in 300 kg of distilled water, add 200 kg of 10% lye, and react with stirring at 80° C. for 4 hours.

[0026] (3) Complexation: After the reaction in step (2) is completed, add the stock solution obtained in step (1) to the solution obtained in step (2), and react at 80° C. for 3 hours under stirring. The pH of the system is always kept at 6. When the reaction is over, adjust the pH of the system to 8 with 30% alkali solution, and the complexation is completed.

[0027] (4) Alcohol precipitation: when the complex solution obtained in step (3) is cooled to room temperature...

Embodiment 3

[0031] A preparation method of iron sucrose bulk drug, characterized in that: the steps of the method are:

[0032] (1) Iron salt basification: dissolve 300kg iron salt and 50kg stabilizer in 600kg distilled water, add 300kg of 40% alkali solution at 20°C, adjust the pH value to 5, filter out the reddish-brown precipitate produced, and put Put into 500kg distilled water for subsequent use.

[0033] (2) Alkalinization: Dissolve 500kg of sucrose in 1000kg of distilled water, add 300kg of 20% lye, and react with stirring at 80°C for 3 hours.

[0034] (3) Complexation: After the reaction in step (2) is completed, add the stock solution obtained in step (1) to the solution obtained in step (2), and react at 100° C. for 3 hours under stirring. The pH of the system is always kept at 5. When the reaction is over, adjust the pH of the system to 7 with 10% alkali solution, and the complexation is completed.

[0035] (4) Alcohol precipitation: when the complex solution obtained in step...

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Abstract

The invention relates to a preparation method of an iron sucrose bulk drug and an injection. The preparation method is characterized in that a ferrous salt and cane sugar undergo a complexation reaction to produce iron sucrose; in the reaction, a stabilizing agent is used so that ferrous ions are not invariably oxidized and enter into a human body. The preparation method creatively improves the existing iron sucrose synthesis method. The iron sucrose prepared from a ferrous salt as a raw material can greatly improve iron sucrose absorption effects, reduce the damage produced by the drug on human body cells, effectively reduce a culture cost and improve iron supplementation effects.

Description

technical field [0001] The invention belongs to the field of iron supplements for piglets in the animal husbandry industry, in particular to a preparation method of an iron sucrose raw material drug and an injection. Background technique [0002] In the feeding process of piglets, the intake of iron is very important. Iron is a trace element necessary for the body. It is an essential component for the body to synthesize hemoglobin. It is also myoglobin, cytochrome, and cytochrome. Components such as enzymes and peroxidases. Primary iron deficiency can cause anemia in newborn piglets. According to statistics, about 30% of piglets die due to iron deficiency. Piglets suffering from anemia mainly occur at the age of 2 to 4 weeks, and the faster the piglets grow, the more iron they store. The faster the amount is consumed, the higher the incidence of anemia. If the iron element is not supplemented in time, it will bring the following unfavorable factors to piglets: (1) cannot f...

Claims

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Application Information

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IPC IPC(8): A61K31/7016A61K9/08A61P3/12C07H23/00C07H1/00
Inventor 安同伟陈庆忠郭嘉
Owner TIANJIN ZHONGAO BIOTECH
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