Stable PGE1 lyophilized emulsion and preparation method thereof

A freeze-dried milk, stabilized technology, applied in the field of medicine
CN103637985AActive Publication Date: 2014-03-19BEIJING TIDE PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING TIDE PHARMA
Publication Date
2014-03-19

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Abstract

The invention provides a stable PGE1 lyophilized emulsion and a preparation method thereof. In particular, by adding vitamin E and refined cane sugar or glucose or a mixture composed of refined sugar and glucose according to a certain ratio, the PGE1 lyophilized emulsion is substantially improved in physical and chemical stability, and thus is capable of bearing severe variation of conditions during freeze drying. The prepared lyophilized product is plump in appearance, is white loose blocks or powder, is good in redissolving property, controllable in quality, good in reappearance and low in rejection rate; also because the usage amount of auxiliary agents is reduced, the production cost of the product is reduced, and the side effects caused by too much added lyophilized preparation auxiliary agents are overcome; and the product is relatively safe to use by patients, and the product is prolonged in validity period and reduced in requirements on production, transportation and storage conditions.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a stable PGE1 freeze-dried milk and a preparation method thereof. Background technique

[0002] PGE1, also known as prostaglandin E1, is a biologically active substance widely present in the body. swedish scientist

[0003] Burgstrom and others won the Nobel Prize in Medicine in 1982 for their discovery of PGE1 and their related pharmacological research. Contents of the invention

[0004] Because PGE1 has a strong drug mechanism of dilating blood vessels and can effectively treat diseases such as chronic arterial occlusive disease, it began to be developed as a drug as early as the 1970s. Since PGE1 is almost insoluble in water and has poor stability, it was mainly coated with co-solvent or cyclodextrin in the early stage and made into a freeze-dried powder injection. Freeze-dried powder injection belongs to systemic administration, and its concentration is relatively large...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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