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Medical chitosan compound moisturizing dressing and preparation method thereof

A chitosan and chitosan solution technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of limited healing effect of chronic wounds, slow wound healing, loss of bioactive substances, etc., to promote rapid healing, The effect of high moisture content and good mechanical properties

Active Publication Date: 2014-04-09
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The traditional dry healing theory believes that wound healing requires a dry environment and the action of oxygen. However, in a dry environment, not only is it easy to dehydrate the wound and scab, it is not conducive to the crawling of epithelial cells, but it is also easy to lose biologically active substances. , resulting in slow wound healing, so medical dressings need to have a good moisturizing effect, provide a moist environment for the wound, and promote rapid wound healing
However, many existing medical chitosan dressings do not have a moisturizing effect, and their effect on promoting chronic wound healing is also very limited. Therefore, researchers in this field are committed to adding other materials on the basis of chitosan to prepare Medical chitosan composite dressing, so as to achieve a more ideal effect

Method used

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  • Medical chitosan compound moisturizing dressing and preparation method thereof
  • Medical chitosan compound moisturizing dressing and preparation method thereof
  • Medical chitosan compound moisturizing dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A preparation method of medical chitosan composite moisturizing dressing, comprising the steps of:

[0039] (1) Add chitosan to a dilute acetic acid solution with a volume fraction of 2.0%, and stir at room temperature until the chitosan is completely dissolved to form a chitosan solution with a mass fraction of 3% for later use;

[0040] (2) Add glycerin to the chitosan solution prepared in step (1), and stir evenly, wherein the mass ratio of chitosan to glycerin is 1:0.125;

[0041] (3) Add polyvinyl alcohol to the chitosan solution prepared in step (2), and stir in a water bath at 90°C until all polyvinyl alcohol is uniformly dissolved, wherein the mass ratio of chitosan to polyvinyl alcohol is 1:0.33;

[0042] (4) After the chitosan solution prepared in step (3) is allowed to stand and cool to room temperature, borate bioactive glass is added to the chitosan solution and stirred for 10 minutes until uniform, wherein chitosan and borate The mass ratio of bioactive ...

Embodiment 2

[0046] A preparation method of medical chitosan composite moisturizing dressing, comprising the steps of:

[0047] (1) Add chitosan to a dilute acetic acid solution with a volume fraction of 2.0%, and stir at room temperature until the chitosan is completely dissolved to form a chitosan solution with a mass fraction of 3% for later use;

[0048] (2) Add glycerin to the chitosan solution prepared in step (1), and stir evenly, wherein the mass ratio of chitosan to glycerol is 1:0.125;

[0049] (3) Add polyvinyl alcohol to the chitosan solution prepared in step (2), and stir in a water bath at 85°C until all polyvinyl alcohol is uniformly dissolved, wherein the mass ratio of chitosan to polyvinyl alcohol 1:0.25

[0050] (4) After the chitosan solution prepared in step (3) is allowed to stand and cool to room temperature, borate bioactive glass is added to the chitosan solution and stirred for 10 minutes until uniform, wherein chitosan and borate The mass ratio of bioactive glas...

Embodiment 3

[0054] A preparation method of medical chitosan composite moisturizing dressing, comprising the steps of:

[0055] (1) Add chitosan to a dilute acetic acid solution with a volume fraction of 2.0%, and stir at room temperature until the chitosan is completely dissolved to form a chitosan solution with a mass fraction of 3% for later use;

[0056] (2) Add glycerin to the chitosan solution prepared in step (1), and stir evenly, wherein the mass ratio of chitosan to glycerol is 1:0.3;

[0057] (3) Add polyvinyl alcohol to the chitosan solution prepared in step (2), and stir in a water bath at 100°C until all polyvinyl alcohol is uniformly dissolved, wherein the mass ratio of chitosan to polyvinyl alcohol is 1:0.33;

[0058] (4) After the chitosan solution prepared in step (3) is allowed to stand and cool to room temperature, borate bioactive glass is added to the chitosan solution and stirred for 10 minutes until uniform, wherein chitosan and borate The mass ratio of bioactive g...

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Abstract

The invention discloses a medical chitosan compound moisturizing dressing which comprises the following components of chitosan, borate bioactive glass, polyvinyl alcohol and glycerinum, wherein the chemical component of the borate bioactive glass is as follows: aNa2O.bK2O.cMgO.dCaO.eB2O3.fP2O5, wherein a, b, c, d, e and f are mol parts, a is 5-9, b is 7-10, c is 7-10, d is 18-25, e is 48-55, f is 1-5, and a+b+c+d+e+f=100; the weight ratio of the chitosan to the borate bioactive glass to the polyvinyl alcohol to the glycerinum is 1:(0.125-0.5):(0.25-0.33):(0.125-0.3). The medical chitosan compound moisturizing dressing is good in moisturizing effect and good in mechanical property, and achieves a more prefect effect in the aspect of promoting a wound, especially a chronic wound, to be rapidly healed.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a medical chitosan composite moisturizing dressing and a preparation method thereof. Background technique [0002] Medical dressings refer to medical materials that cover wounds, temporarily protect wounds, prevent infection, and promote healing. As we all know, chitosan has good biocompatibility, skin affinity and degradability in various biomaterials of new medical dressings, and it also has good effects in antibacterial, hemostasis and promotion of wound healing. Therefore, Chitosan has broad application prospects in the field of medical dressings. [0003] The traditional dry healing theory believes that wound healing requires a dry environment and the action of oxygen. However, in a dry environment, not only is it easy to dehydrate the wound and scab, it is not conducive to the crawling of epithelial cells, but it is also easy to lose biologically active substances. , r...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/18A61L15/24A61L15/20A61L15/44
Inventor 赵晓丽吴帅黄卓瑶潘浩波
Owner SHENZHEN INST OF ADVANCED TECH
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