New use of stibene glucoside in preparing medicament for treating Alzheimer disease

A technology for Alzheimer's disease and stilbene glycosides, applied in the field of medicinal chemistry, can solve problems such as information transmission obstacles, cell swelling and necrosis, and learning and memory defects

Inactive Publication Date: 2014-04-30
LANZHOU GENERAL HOSPITAL OF LANZHOU MILITARY REGION PLA
View PDF1 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Experiments have proved that the neurotoxicity of excitatory amino acids has the following links: in Alzheimer's disease, β-amyloid can inhibit the sugar uptake and transport of excitatory amino acids in cultured hippocampal glial cells, thereby producing toxic effects; excessive The excitatory amino acid activates N-methyl-D-aspartate (NMDA) receptors, causing continuous depolarization of excitatory neurons, resulting in changes in ions, osmotic

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New use of stibene glucoside in preparing medicament for treating Alzheimer disease
  • New use of stibene glucoside in preparing medicament for treating Alzheimer disease
  • New use of stibene glucoside in preparing medicament for treating Alzheimer disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]Animal grouping and intervention: 60 3-month-old APP695V717I transgenic mice were purchased from the Institute of Experimental Animals, Chinese Academy of Medical Sciences (permit number: SCKK 20080013), weighing (30±4.5) g, male or female, with the same age and the same background Thirty C57BL / 6J mice were used as blank control group. The selected animals were grouped using a random number table, and divided into control group, model group, and stilbene glycoside (TSG) group, each with 30 animals. The intragastric administration solution of the blank control group and the model group was physiological saline, and the intragastric administration solution of the stilbene glycoside group was a stilbene glycoside suspension. The animals in the above groups were given medicine 3 days before the start of the experiment, and were administered orally once a day for 3 consecutive weeks. The amount of oral administration was calculated as 100mg / kg.d (the middle dose concentration...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention aims to disclose new use of stibene glucoside in preparing medicament for treating Alzheimer disease. Experiments in which APP695V717I transgenic mouse is used to simulate nerve cell damage in Alzheimer disease prove that pre-administered stibene glucoside can significantly improve behavioral disorders of model mouse by improving brain blood circulation, reducing expression of apoptosis factor Fas/FasL and inhibiting excitatory amino acid level, suggesting that stibene glucoside has distinct protective effect on nerve cell damage in Alzheimer disease. Stibene glucoside prevents and treats Alzheimer disease through multi-target action, stibene glucoside and related adjuvants can be prepared into health products or medicaments for improving cognitive function and treating Alzheimer disease by conventional preparation method. The health products or medicaments can be used for delaying and improving cognitive function and slowing down the progression of Alzheimer disease, and improving physical constitution and life quality of the elderly.

Description

technical field [0001] The present invention relates to a new medical application of stilbene glycosides, in particular to improving cerebral circulation deficiency in Alzheimer's disease and reducing excessive apoptosis factor Fas / FasL in the preparation of drugs for preventing and treating Alzheimer's disease. The expression and the new application of inhibiting the increase of the excitatory amino acid level belong to the field of medicinal chemistry. [0002] Background technique [0003] Stilbene glycoside (2,3,5,4-tetrahydroxy stilbene-2-O-β-D glucoside, Tetrahydroxy Stilbene Glycoside, TSG) belongs to polyhydroxy stilbene compounds, molecular formula is C20H22O9, molecular weight is 406, The molecular structure is as follows: [0004] [0005] Stilbene glycosides are hereinafter referred to as TSG for short, and can be purchased directly in the market, and their content can be analyzed by high performance liquid chromatography. [0006] Alzheimer's disease (AD)...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/7034A61P25/28A23L1/30A23L33/105
Inventor 罗红波李芸石向群郭建魁汪泳张志强
Owner LANZHOU GENERAL HOSPITAL OF LANZHOU MILITARY REGION PLA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap