Preparation method of three-dimensional artificial random porous structure tissue engineering scaffold

A technique for tissue engineering scaffolds and porous structures, which is applied in the preparation of biomedical tissue engineering scaffold materials and the design and preparation of three-dimensional artificial random structure tissue engineering scaffolds. porous structure etc.

Inactive Publication Date: 2014-04-30
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The purpose of the present invention is to solve the problems that the traditional design method cannot flexibly and accurately construct the random porous structure, and the traditional preparation method has high cost, unstable process, residual pore-forming agent, low strength of the scaffold, etc., and provides a tissue engineering of a three-dimensional artificial random porous structure Scaffold Preparation Method

Method used

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  • Preparation method of three-dimensional artificial random porous structure tissue engineering scaffold
  • Preparation method of three-dimensional artificial random porous structure tissue engineering scaffold
  • Preparation method of three-dimensional artificial random porous structure tissue engineering scaffold

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Embodiment 1

[0025] The preparation method of the tissue engineering scaffold of the three-dimensional artificial random porous structure provided by the present invention is to design the random porous structure based on the triple periodic minimum surface method, and to prepare the scaffold by using the additive manufacturing method. The specific steps are:

[0026] 1. Establish a 3D digital internal and external model of the artificial random porous structure scaffold, the steps are:

[0027] a. Construct a random function according to the distribution range of the porosity and pore size of the natural tissue, so that the function value range is within the distribution range;

[0028] Sprinkle t=27 regularly distributed 3D points into the cube, and the coordinates of each point are (t1[il,i2[il,x3[il), construct a random function:

[0029] f ( x , y , z ) = ...

Embodiment 2

[0053] image 3 It is the design outline drawing of artificial joint parts (see Example 1 for the specific design process), and the required material is titanium metal, in which the radius of the outer surface of the hemisphere is 32mm, the radius of the inner surface is 26mm, the eccentricity of the inner and outer spherical surfaces is 5.5mm, and the spherical shell is connected to the cylindrical tube The thickness is consistent with the thickness of the spherical shell, the height of the outer surface and the inner surface are 7mm and 12.2mm respectively, the top of the spherical shell is punched with Ф3mm, and there are 6 holes of Ф6mm in an equidistant annular array around it, the axis passes through the center of the outer spherical surface and is connected to the bottom surface The included angle is 50°. It is required that the surface layer is distributed with random porous structure, and the inner layer is a solid structure. The 3D model designed according to the sc...

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Abstract

The invention relates to a preparation method of a three-dimensional artificial random porous structure tissue engineering scaffold, belonging to the technical field of biomaterials. The invention aims to solve the design and manufacturing problems of the bionic structure of tissue engineering scaffold, provides a design method for constructing a random distributed scaffold porous structure with a bionic shape under expected porosity and pore size requirements, and molds by using a 3D additive manufacturing method to produce tissue substitute. The preparation method provided by the invention has the following advantages that the scaffold has a 3D through-hole structure meeting bionic requirements, and ensures nutrient substance transfer and waste metabolism and has certain bionic mechanical properties; the porosity and pore size distribution range of the scaffold can be conveniently controlled, and the random pore structure with expected function gradient is constructed to realize the bionic characteristic of the structure; and the method is suitable for a large range of materials such as metal materials, non-metal materials and medical high molecular materials, and can meets user-personalized tissue repair requirements.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and is particularly suitable for the preparation of scaffold materials for biomedical tissue engineering, specifically a method for designing and preparing a three-dimensional artificial random structure tissue engineering scaffold. Background technique [0002] Tissue engineering is an emerging medical technology. It applies the principles and technologies of life science and engineering. Based on a correct understanding of the relationship between tissue structure and function in normal and pathological states, it researches and develops methods for repairing and maintaining various aspects of the human body. Biological substitutes for the function and shape of tissues and organs after damage have attracted much attention. Its core is a three-dimensional space complex composed of biological materials and cells. The basic method is to adsorb normal tissue cells cultured in vitro on a biolog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56
Inventor 杨楠
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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