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Hydroxypropyl-beta-cyclodextrin chiral composite membrane, and applications thereof

A chiral composite membrane and cyclodextrin technology, which is applied in membrane technology, semi-permeable membrane separation, climate sustainability, etc., can solve the problems that have not yet been reported in the public application of hydroxypropyl-β-cyclodextrin composite membrane , to achieve the effect of easy large-scale industrial production, low cost and low energy consumption

Inactive Publication Date: 2014-04-30
YUNNAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] So far, there is no public report on the hydroxypropyl-β-cyclodextrin composite membrane and its application in the resolution of p-hydroxyphenylglycine racemate

Method used

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  • Hydroxypropyl-beta-cyclodextrin chiral composite membrane, and applications thereof
  • Hydroxypropyl-beta-cyclodextrin chiral composite membrane, and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The commercial polysulfone membrane is used as the base membrane, soaked in deionized water for two days, dried vertically, soaked in 0.02g / mL hydroxypropyl-β-cyclodextrin solution for 3h, taken out and dried vertically. Interfacial polymerization with 0.012g / mL 1,6-hexamethylene diisocyanate heptane solution, polymerization time 10s. Take out the polysulfone membrane, wait for the surface reagent to volatilize, put it in a drying oven at 110°C, and heat-treat it for 20 minutes. The polysulfone composite membrane is washed with deionized water to obtain the required hydroxypropyl-β-cyclodextrin chiral composite membrane.

Embodiment 2

[0035] The commercial polysulfone membrane is used as the base membrane, soaked in deionized water for two days, dried vertically, soaked in 0.02g / mL hydroxypropyl-β-cyclodextrin solution for 3h, and taken out vertically for 0.5h. Perform interfacial polymerization with 0.021g / mL1,3,5-tribenzoylchloroheptane solution, and the polymerization time is 20s. Take out the polysulfone membrane, wait for the surface reagent to volatilize, put it in a drying oven at 110°C, and heat-treat it for 25 minutes. The polysulfone composite membrane is washed with deionized water to obtain the required hydroxypropyl-β-cyclodextrin chiral composite membrane.

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Abstract

The invention discloses a hydroxypropyl-beta-cyclodextrin chiral composite membrane, and applications thereof. A preparation method of the hydroxypropyl-beta-cyclodextrin chiral composite membrane comprises following steps: a polysulfone membrane is immersed in deionized water for two days, is dried vertically in the air, is immersed in a hydroxypropyl-beta-cyclodextrin solution with a concentration of 0.02g / ml, is dried vertically in the air, and is subjected to interfacial polymerization with a 1,6-hexanedioldiisocyanate solution with a concentration of 0.012g / ml; an obtained product is collected, is washed with deionized water after volatilization of reagents on the surfaces, and is dried in that air so as to obtain a chiral composite membrane; and the chiral composite membrane is delivered into a common dialysis device, and d-p-hydroxyphenylglycine raceme solution is separated by concentration difference, wherein purity of d-p-hydroxyphenylglycine enantiomer in a permeate liquid is more than 55%. The purity of the enantiomer obtained via the preparation is relatively high; cost is low; energy is saved; environment is protected; and the preparation method is convenient for continuous operation and large-scaled industrialized production.

Description

technical field [0001] The invention belongs to the technical field of polymer membrane chiral separation, and in particular relates to a hydroxypropyl-β-cyclodextrin chiral composite membrane. At the same time, the invention also relates to the application of the chiral composite membrane in the separation of p-hydroxyphenylglycine racemate. Background technique [0002] Chiral drugs refer to a pair of enantiomers that are mirror images of each other after introducing a chiral center into the molecular structure of a drug. Since the pharmacokinetic processes of the two enantiomers in chiral drugs are different, chiral drugs There are often significant differences in the pharmacological activity, metabolic process, metabolic rate and toxicity of the two enantiomers in the organism. There may be the following situations: only one of the two enantiomers has pharmacological activity, And the other has no significant pharmacological effect; one of the two enantiomers has activi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/12B01D67/00B01D71/68C07C229/36C07C227/34
CPCY02P20/10
Inventor 袁黎明王瑞麟段爱红涂代梅
Owner YUNNAN NORMAL UNIV
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