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Composition for improving in vivo metabolism parameter

A composition and body technology, applied in the direction of drug combination, application, animal feed, etc., can solve problems such as unclear mechanism of action

Inactive Publication Date: 2014-05-21
RARE SUGAR FOODS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, properties such as fat loss (patent document 2) are also evident, but the mechanism of action is still unclear

Method used

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  • Composition for improving in vivo metabolism parameter
  • Composition for improving in vivo metabolism parameter
  • Composition for improving in vivo metabolism parameter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073]

[0074]In Japan, it has been found that the number of patients with lifestyle-related diseases, especially diabetes, is increasing. Therefore, subjects involved in diabetes were recruited to carry out clinical trials, and the changes in body metabolic parameters of D-psicose were investigated. As subjects, borderline diabetic subjects (blood sugar level on an empty stomach: 110-126 mg / dl: 12 subjects) and diabetic patients (type 2 diabetic patients receiving diabetes medication: 6 subjects) were recruited (when consent was obtained: men and women over the age of 20). The intake period was 12 weeks, and the intake amount was 5 g of D-psicose per serving. D-Psicose was purchased from Rare Sugar Production Technology Research Institute Co., Ltd. The inspections are the day of intake start (0 week), 2 weeks after intake (2 weeks), 4 weeks after intake (4 weeks), 8 weeks after intake (8 weeks), 12 weeks after intake (12 weeks) and the end of intake 4 After one week (16...

Embodiment 2

[0080]

[0081] Healthy subjects (blood sugar level on an empty stomach 110 mg / dl: 8 subjects) and borderline diabetic subjects (blood sugar level on an empty stomach 110-126 mg / dl, or HbA1c 5.9-6.5%: 6 subjects) were recruited (6 subjects when consent was obtained). Men and women over 20 years old) conducted a 4-week D-psicose intake test. As the intake, 15 g of D-psicose was taken once a day.

[0082] D-Psicose was purchased from Rare Sugar Production Technology Research Institute Co., Ltd. The inspection days were the day when the intake started (week 0), 2 weeks after the intake (2 weeks), 4 weeks after the intake (4 weeks), and 4 weeks after the end of the intake (8 weeks: post-observation period), and the dinner on the day before the test day Stop eating afterwards. The measurement items were γ-GTP, ALT, and ALP, and the measurement was entrusted to the First Clinical Laboratory Center of Co., Ltd. Statistics were compared with a certain t-test before and after the ...

Embodiment 3

[0086]

[0087] As experimental animals, 3-week-old Wistar male rats (CLEA Japan, Inc.) were used in 1 group of 7 rats, 14 rats. During the 1 week of domestication period, they were fed with solid feed CE-2 (CLEA Japan, Inc.). After the acclimatization period is over, the groups are grouped according to body weight. The basic composition of the feed is shown in Table 1. Syrups containing rare sugars were produced by feeding a 10% (w / v) solution of isomerized sugars to a strongly basic ion exchange resin (resin: Amberlite IRA900J[Cl]) at a temperature of 60°C. The sugar composition of the reaction solution was 40% of D-glucose, 31% of D-fructose, 7% of D-psicose, and 22% of other sugars including D-mannose and D-allose.

[0088] They were allowed to freely ingest feed and drinking water, and were reared for 8 weeks, respectively. After the rearing was completed, the rats were sequentially laparotomized under ether anesthesia, and blood was collected from the abdominal aort...

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Abstract

The invention provides a composition for improving an in vivo metabolism parameter. A composition containing D-psicose as an active ingredient, which can be used for giving D-psicose at a dose of 5 g or more for each time continuously for the purpose of decreasing an in vivo metabolism parameter, i.e., a uric acid level and / or a level of a hepatic function indicator component. The level of 15 g gamma-GTP is significantly decreased from week 4 of the ingestion of the composition. When the composition is given continuously at a dose of 5 g or more in terms of D-psicose content three times a day, the level of gamma-GTP is significantly decreased from week 4 of the ingestion of the composition and the level of ALP is significantly decreased from week 2 of the ingestion of the composition.

Description

technical field [0001] The invention relates to a composition for improving body metabolism parameters with D-psicose as an active ingredient. [0002] In the present invention, the index component value of the liver function and the uric acid value are collectively referred to as body metabolic parameters. Background technique [0003] The liver is the largest glandular internal organ in the human body and is an internal organ indispensable to the survival of the body. The liver is made up of about 300 billion cells in total. The functional characteristics of the liver include various bodily reactions such as metabolic storage of nutrients, detoxification, phagocytosis of foreign substances or microorganisms, and regulation of blood circulation volume. [0004] Representative indicators of this liver function include γ-GTP (γ-glutamyl transpeptidase), ALT (alanine aminotransferase), AST (aspartate aminotransferase), ALP (alkaline phosphate enzymes) and other indicators. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7004A23K1/16A23L1/30A23L2/52A61P1/16A61P19/06C07H3/02A23L27/30A23L33/125
CPCA23L2/52A61K31/7004A23K20/163A23L29/30A23L33/10A23L33/125A61P1/16A61P19/06C07H3/02
Inventor 山田晃士林范子山田贵子
Owner RARE SUGAR FOODS
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