Salviae miltiorrhizae injection and preparation method thereof

Abstract

The invention provides a salviae miltiorrhizae injection and a preparation method thereof. The salviae miltiorrhizae injection comprises salviae miltiorrhizae active constituents and a buffer pair reagent combination, wherein the salviae miltiorrhizae active constituents comprise one or more of salvianic acid A sodium, protocatechualdehyde, rosmarinic acid and salvianolic acid B; the buffer pair reagent combination comprises one or more of a pharmaceutically acceptable antioxygen, organic weak acid and organic weak acid conjugate base; the antioxygen is selected from one or more of sodium pyrosulfite, sodium hydrogen sulfite and sodium sulfite. The invention further discloses a preparation method of the salviae miltiorrhizae injection. The salviae miltiorrhizae injection is high in quality stability; the preparation method is simple and convenient in operation, special equipment is not required, and industrial production of the salviae miltiorrhizae injection is easy.

Description

[0001] Technical field: The present invention relates to the field of pharmaceutical preparations, in particular to an injection containing active ingredients of Danshen and a preparation method thereof. Background technique: [0002] The traditional Chinese medicine Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza Bunge, which has the effects of promoting blood circulation, removing blood stasis, relieving pain, nourishing blood and calming the nerves, clearing the heart and eliminating troubles. Modern pharmacological and clinical studies have shown that Salvia miltiorrhiza has obvious protective effects on ischemic myocardium and reperfused heart, and can improve metabolic disorders caused by tissue cell ischemia and hypoxia; Promote the degradation of fibrinogen and so on. In addition, Danshen can improve renal microcirculation, increase renal blood flow, protect and repair ischemic kidneys, and have anti-ulcer, antibacterial, anti-inflammatory, and r...

AI Technical Summary

Problems solved by technology

[0006] CN101897754A discloses a Danshen drug injection containing polyethylene glycol lauryl hydroxystearate, which improves the clarity of the injection while obtaining the maximum solubility, and solves the problem that the Danshen injection is prone to precipitation during storage and high-temperature sterilization. Turbidity and other problems

[0007] CN101884667 discloses a Xiangdan drug injection containing polyethylene glycol lauryl hydroxystearate, which improves the clarity of the Xiangdan drug injection preparation, and solves the problem of using existing cosolvents in the storage and high temperature extinction of the Xiangdan drug injection preparation. It is prone to rancidity during the sterilization process, resulting in high content of impurities, easy chemical changes with drug ingredients, and problems such as turbidity of the solution during storage.

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