Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

The application of 1,2-benzenediol in the fungus Phylonotus in resisting avian influenza h5n1 virus

A technology of Phylopora spp. and hydroquinone, which is applied in the field of application of 1,2-benzenediol in the anti-avian influenza H5N1 virus in Phylopora spp., which can solve the problem of no anti-avian influenza virus activity. and other issues, to achieve the effect of clear structure and mature and clear technical route

Inactive Publication Date: 2015-12-02
QINGDAO AGRI UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Hydroquinone has a variety of important physiological activities such as antibacterial, so far, no reports of anti-avian influenza virus activity have been seen

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • The application of 1,2-benzenediol in the fungus Phylonotus in resisting avian influenza h5n1 virus
  • The application of 1,2-benzenediol in the fungus Phylonotus in resisting avian influenza h5n1 virus
  • The application of 1,2-benzenediol in the fungus Phylonotus in resisting avian influenza h5n1 virus

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0034] The crude extract of Phylophorus chrysogenum is prepared by the following method:

[0035] (1) The fermentation medium formula is in grams / 100 milliliters:

[0036] Corn Starch 1% Glucose 1%

[0037] Peptone 0.1% Yeast Extract 0.1%

[0038] Magnesium sulfate 0.1% Potassium dihydrogen phosphate 0.01%

[0039] (2) Inoculate the Phyloporus spp. strains into the Erlenmeyer flask with liquid medium in a conventional manner, with a temperature of 25° C., a shaker flask rotation speed of 110 r / min, and pH 7 conditions, and vibrate for 7 days; during the cultivation When the pH value drops to 3, inoculate the seeds in the shake flask into the culture solution of a 50L fermenter, with a temperature of 25°C, a fermenter pressure of 0.1 kg / cm2, pH 3, an air flow of 0.5-1.1vvm, and a stirring speed of 100 Under the condition of rev / min, after culturing for 7 days, the crude extract of Ph.

[0040] (3) Take the fermented whole solution of Phylophorus mycelium obtained in step (2...

example 2

[0051] The crude extract of Phylophorus chrysogenum is prepared by the following method:

[0052] (1) The fermentation medium formula is in grams / 100 milliliters:

[0053] Corn Starch 3% Glucose 2%

[0054] Peptone 0.5% Yeast Extract 0.5%

[0055] Magnesium sulfate 0.5% Potassium dihydrogen phosphate 0.05%

[0056] (2) Inoculate the Phylophorus spp. strain into the Erlenmeyer flask with liquid medium in a conventional way, with a temperature of 30° C., a shaker flask rotation speed of 180 r / min, and pH 6 conditions, and vibrate for 15 days; during the cultivation When the pH value drops to 2.5, inoculate the seeds in the shake flask into the culture solution of a 50L fermenter, with a temperature of 30°C, a fermenter pressure of 0.2 kg / cm2, a pH of 3, an air flow of 0.5-1.1vvm, and a stirring speed of 180 Under the condition of rev / min, after culturing for 15 days, the crude extract of Ph.

[0057] (3) Take the fermented whole solution of the Phlomophorus mycelium obtained...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses 1,2-benzenediol with an avian influenza-resisting activity, which is separated from fermentation broth and fruiting bodies of phellinus igniarius (LexFr) Quel (phellinus linteus (BerketCurt) Teng, phellinus baumii and phellinus hartigii (AlleschetSchnabl) Imaz). The invention firstly discloses a new activity of 1,2-benzenediol and proves that the 1,2-benzenediol has an avian influenza-resisting action. Compared with the application of a general compound, the method has the advantages that the special new activity of 1,2-benzenediol is found, and the 1,2-benzenediol has the action of resisting the avian influenza virus.

Description

technical field [0001] The present invention relates to a method for extracting and preparing active substances in Phylopora spp. which is resistant to avian influenza H5N1 virus, and in particular to the S. syringum strain, which was preserved in Beichen, Chaoyang District, Beijing on August 26, 2013. No. 3, No. 1 West Road, Institute of Microbiology, Chinese Academy of Sciences, "Common Microbiology Center of China Microbiological Culture Collection Management Committee", taxonomic name: Phellinusigniarius, and the preservation number is CGMCCNo.8108. Background technique [0002] Hydroquinone can volatilize with steam and is a strong reducing agent. It can burn when exposed to open flames. It emits toxic and corrosive odors when exposed to high heat. It can cause poisoning through the skin and can sublimate. It has a stimulating effect on the central nervous system and respiratory system. Rat oral LD50 is 3890mg / kg, which is different from resorcinol and hydroquinone. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/05A61P31/16C07C39/08C07C37/82A01G1/04
Inventor 赵晨宋爱荣孔超孙效乐秦丹
Owner QINGDAO AGRI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com