Method for preparing micron-sized biological activity glass and application thereof in departments of orthopedics and dentistry

A bioactive glass and solution technology, applied in dentistry, dental preparations, dental prostheses, etc., to achieve the effect of simple equipment and low raw material prices

Inactive Publication Date: 2014-06-11
JIANGSU HIDREAM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since only non-crystalline bioglass has good bioactivity, and bioactive glass itself is prone to phase separation, it is difficult to obtain a bioglass that does not crystallize during repeated heat treatments through existing technologies, unless Add magnesium, boron oxide and other additives to maintain its biological activity

Method used

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  • Method for preparing micron-sized biological activity glass and application thereof in departments of orthopedics and dentistry
  • Method for preparing micron-sized biological activity glass and application thereof in departments of orthopedics and dentistry
  • Method for preparing micron-sized biological activity glass and application thereof in departments of orthopedics and dentistry

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1) Add 7ml of concentrated nitric acid to 53g of absolute ethanol and mix to obtain solution I;

[0027] 2) Add 24.17g of ethyl orthosilicate to solution I, pre-hydrolyze for 30min (room temperature, 1000rpm) to obtain solution II;

[0028] 3) Add 1.7g of phosphorus pentoxide to solution II, stir at 1000rpm for 30min, to obtain solution III;

[0029] 4) Add 17g of calcium nitrate tetrahydrate to solution III, stir at 1000rpm for 1h, fully dissolve and form a clear gel.

[0030] 5) Place the clear gel in a closed container and age it in an oven at 60°C for 72 hours to form a gel;

[0031] 6) Dry the gel in an oven at 130°C for 72 hours, sieving by ball milling to obtain dry gel powder;

[0032] 7) The dry gel powder is calcined at 700° C. for 2 hours to obtain bioactive glass powder.

Embodiment 2

[0034] 1) Add 7ml of concentrated nitric acid to 53g of absolute ethanol and mix to obtain solution I;

[0035] 2) Add 24.17g of ethyl orthosilicate to solution I, pre-hydrolyze for 30min (room temperature, 1000rpm) to obtain solution II;

[0036] 3) Add 2.83g of phosphorous pentoxide to solution II, stir at 1000 rpm for 30 minutes to obtain solution III;

[0037] 4) Add 15.11 g of calcium nitrate tetrahydrate to solution III, stir at 1000 rpm for 1 hour, and fully dissolve to form a clear gel.

[0038] 5) Place the clear gel in a closed container and age it in an oven at 60°C for 72 hours to form a gel;

[0039] 6) Dry the gel in an oven at 130°C for 72 hours, sieving by ball milling to obtain dry gel powder;

[0040] 7) The dry gel powder is calcined at 700° C. for 2 hours to obtain bioactive glass powder.

Embodiment 3

[0042] 1) Add 7ml of concentrated nitric acid to 53g of absolute ethanol and mix to obtain solution I;

[0043] 2) Add 24.17g of ethyl orthosilicate to solution I, pre-hydrolyze for 30min (room temperature, 1000rpm) to obtain solution II;

[0044] 3) Add 4.25g of phosphorous pentoxide to solution II, stir at 1000 rpm for 30 minutes to obtain solution III;

[0045] 4) Add 12.75g of calcium nitrate tetrahydrate to solution III, stir at 1000 rpm for 1 hour, fully dissolve and form a clear gel.

[0046] 5) Place the clear gel in a closed container and age it in an oven at 60°C for 72 hours to form a gel;

[0047] 6) Dry the gel in an oven at 130°C for 72 hours, sieving by ball milling to obtain dry gel powder;

[0048] 7) The dry gel powder is calcined at 700° C. for 2 hours to obtain bioactive glass powder.

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Abstract

The invention discloses a method for preparing micron-sized biological activity glass and an application thereof in departments of orthopedics and dentistry, belonging to the field of pharmacy. The biological activity glass is prepared by the following steps of uniformly mixing concentrated nitric acid with ethyl alcohol so as to obtain a solution I, adding ethyl orthosilicate into the solution I, pre-hydrolyzing so as to obtain a solution II, adding phosphorus pentoxide into the solution II, stirring so as to obtain a solution III, adding calcium nitrate tetrahydrate into the solution III, stirring fully to dissolve so as to form clear gel, then putting in a 60DEG C oven to gelate, drying for 72 hours at 130DEG C, finally, ball milling, sieving, calcining at 700DEG C so as to obtain the biological activity glass. The method has the advantages that the prepared biological activity glass can be heated repeatedly without crystallizing, can be prepared into different shapes, is applicable to plastic surgery operations like bone graft, bone defect filling and oral rehabilitation, the equipment is simple, the cost of the raw materials is low, and the glass can be produced on a large scale.

Description

Technical field [0001] The invention relates to bioactive glass and a preparation method thereof. The bioactive glass can be used to fill bone defects and tooth defects and repair. Background technique [0002] Bioactive glass (MMBG) is one of the current research hotspots of bone tissue repair materials. It has good biological activity and biocompatibility. Its main ingredients include CaO-P 2 O 5 -SiO 2 -MO (M=Na, Mg, etc.), after implantation in the human body, through the circulation of body fluids, the bioactive glass can exchange ions with soft tissues and bones to form a chemical bond between the material interface and the human bone tissue. This ion exchange plays a role of mineralization, and finally forms a light-based apatite (HA) layer that is the same as the mineral form of normal bone tissue, which can induce more rapid bone repair and regeneration. [0003] An active layer is formed on the surface of bioactive glass to play a role in bonding medical devices and hum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C03C3/062C03C12/00C03B8/02A61L27/10A61K6/033A61K6/027A61K6/838
Inventor 董毅翔
Owner JIANGSU HIDREAM BIOTECH
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