A kind of pharmaceutical composition for preventing and treating breast cancer and its application
A composition and technology for breast cancer, applied in the field of medicine, can solve the problems of no literature report on cetirizine hydrochloride, no literature report on cetirizine hydrochloride for breast cancer, etc., and achieve significant social and economic significance, tumor inhibitory activity and the like. Significant, enriching effects of existing technology
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Embodiment 1
[0016] Embodiment 1: the preparation of tablet
[0017]
[0018] Preparation Process:
[0019] Pass tegafur and cetirizine hydrochloride through a 120-mesh sieve, dissolve them in hot water at 60-80°C with β-cyclodextrin, keep for more than 60 minutes, cool, filter after the β-cyclodextrin precipitates, dry, and pass Sieve; mannitol, low-substituted hydroxypropyl cellulose, and aspartame are passed through a 100-mesh sieve, weighed according to the prescription amount, mixed evenly, add an appropriate amount of distilled water, granulate, dry, granulate, add the prescription amount of talcum powder, Mix well and press into tablets.
Embodiment 2
[0020] Embodiment 2: the preparation of tablet
[0021]
[0022] Preparation Process:
[0023] Pass tegafur and cetirizine hydrochloride through a 120-mesh sieve, thoroughly grind and mix with β-cyclodextrin, pass through a 100-mesh sieve for lactose, sodium carboxymethyl starch, and lemon essence, weigh according to the prescription, and mix evenly. Add appropriate amount of distilled water, granulate, dry, granulate, add prescription amount of magnesium stearate, mix well, and tablet.
Embodiment 3
[0024] Embodiment 3: The combination of cetirizine hydrochloride and tegafur
[0025] 40 SPF grade BALB / c-nu mice, 6 weeks old, weighing 18g-20g. In the logarithmic growth phase, the medium in the bottle of MDA-MB-231 breast cancer cells with a confluence of 80% to 90% was aspirated and discarded, the cells were washed 2-3 times with phosphate buffer, digested with trypsin (0.25%), Cells were collected, washed again with phosphate buffered saline, mixed by pipetting, and counted; then the concentration was adjusted with serum-free RPMI-1640, and the number of cells inoculated subcutaneously on the back of each nude mouse was 1.0×10 7 / 0.2mL cell suspension was injected subcutaneously on the back of nude mice. From 7 days after the inoculation, small nodules were visible under the skin at the site of tumor cell inoculation, with a size of about 5mm×5mm; on the 10th day, the size of the tumor was about 7mm×7mm.
[0026] Thirty-five nude mice with tumors were taken and divided ...
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