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Process for separating and extracting angelica polysaccharide and application thereof

An extraction process and technology of Angelica sinensis, which is applied in the fields of blood diseases, extracellular fluid diseases, anti-tumor drugs, etc., can solve the problems of low content of biological activity, etc., and achieve the effect of high purity and simple and easy extraction, separation and purification methods.

Inactive Publication Date: 2014-06-18
CHONGQING MEDICAL UNIVERSITY
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  • Description
  • Claims
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Problems solved by technology

However, due to the low content (30%-60%) of angelica polysaccharides extracted in the past, it has a certain impact on the judgment of its biological activity, so how to obtain angelica polysaccharides with high sugar content through extraction, separation and purification is the key to study its pharmacological effects. important premise

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  • Process for separating and extracting angelica polysaccharide and application thereof
  • Process for separating and extracting angelica polysaccharide and application thereof
  • Process for separating and extracting angelica polysaccharide and application thereof

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Embodiment Construction

[0010] 1. Materials

[0011] 1.1 Medicinal materials: Peeled angelica head, Min County, Gansu, China, purchased from the Chinese herbal medicine market in Chongqing

[0012] 1.2 Reagents:

[0013] 95%EtOH: medical alcohol Chongqing Beibei Distillery

[0014] Dialysis bag (molecular weight cut off 10000): Huamei Bioengineering Company

[0015] Calcium Hydroxide: AR Chongqing Dongfang Reagent Factory

[0016] 732 strong acid cationic resin: Shanghai Zhenguang Resin Factory

[0017] 717 strong basic anion resin: Shanghai Zhenguang Resin Factory

[0018] h 2 SO 4 : AR State-run Chongqing Inorganic Chemical Reagent Factory

[0019] Hydrochloric acid: AR State-run Chongqing Inorganic Chemical Reagent Factory

[0020] Sodium hydroxide: AR Beijing Hongxing Chemical Factory

[0021] Trichloroacetic acid: AR Shanghai Sanaisi Reagent Co., Ltd.

[0022] pH test paper: Tianjin Chemical Reagent Factory

[0023] 1.3 Instruments

[0024] Electronic thermostat heating mantle: Tianj...

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Abstract

The invention discloses a process for separating and extracting angelica polysaccharide and application thereof. The process comprises the following steps: directly extracting angelica sinensis crude powder by water, precipitating by using 95% ethanol to obtain crude polysaccharide after concentrating an extracting solution; adding saturated Ca(OH)2 to remove protein after dissolving the crude polysaccharide by water; processing by strong acid cation exchange resin (SACER) and strong-base anion exchange resin (SBAER) respectively; dialyzing by using a dialysis bag after concentrating, so as to obtain the angelica polysaccharide after concentrating. The extraction and separation method disclosed by the invention is simple and feasible, the obtained neutral angelica polysaccharide is high in purity, and the angelica polysaccharide has a significant increasing effect on peripheral blood white blood count (WBC) and LC in mice. Thus, theoretical direction and an experiment basis are provided for further research of the mobilization action of the angelica polysaccharide on hydrogenated soy phosphatidylcholine (HSPC).

Description

technical field [0001] The invention belongs to the technical field of natural medicines, and in particular relates to a process for separating and extracting polysaccharides from Angelica sinensis and its application. Background technique [0002] Angelica sinensis is the dried root of Angelica sinensis diel, which is mainly produced in Minxian County, Gansu, Yunnan, Sichuan, Shaanxi, Hubei and other places in China. Angelica is sweet, pungent, and warm in nature. It is a well-known and commonly used traditional Chinese medicine. It has the effects of nourishing blood and promoting blood circulation, regulating menstruation, relieving pain, and laxative. . With the in-depth research on Angelica sinensis and the application of new technologies, a variety of chemical active ingredients have been isolated: ligustilide, ferulic acid, angelica polysaccharides, trace elements, vitamins, amino acids, chalcone, Semiterpenes, alkyne compounds. In recent years, the promotion of he...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P7/00A61P35/00A61P35/02
Inventor 尚京川辜鹏程封家福张梦
Owner CHONGQING MEDICAL UNIVERSITY
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