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Preparation method and application of low-molecular porphyra haitanensis polyferose compound

A technology of laver and low molecular weight is applied in the treatment and prevention of iron-deficiency anemia, in the field of preparation of polysaccharide iron complexes, and can solve the problems of low absorption rate and the like, and achieves simple operation, low manufacturing cost and stable preparation process. Effect

Active Publication Date: 2014-06-18
HUZHOU TEACHERS COLLEGE
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Problems solved by technology

However, the absorption rate of oral high molecular weight polysaccharides is very low, so whether high molecular weight polysaccharide iron can also be directly absorbed in molecular form like low molecular weight iron preparations, and what is the optimal molecular weight range that can be absorbed needs to be further explored

Method used

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Embodiment Construction

[0022] 1. Preparation of Porphyra polysaccharide

[0023] Weigh 100 g of dried Porphyra laver and crush it into a high-pressure extractor, add 40 times distilled water and extract at 105 °C for 3 hours. The extract is firstly filtered with gauze to remove the algae residue, and then filtered with diatomaceous earth to obtain a clear extract. The extract was placed in a dialysis bag with a molecular weight cut-off of 3500 Da, dialyzed with running tap water for two days and distilled water for one day, then concentrated under reduced pressure, adding absolute ethanol to the concentrated solution to make the final concentration of ethanol reach 75%, and a flocculent white precipitate was obtained. The precipitate was washed with absolute ethanol and then dried to obtain 42 g of polysaccharides from Porphyra laver.

[0024] 2. Preparation of low molecular weight Porphyra polysaccharide

[0025] Dissolve 4 g of the polysaccharides of the above altar laver raw materials i...

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Abstract

The invention provides a preparation method and application of a low-molecular porphyra haitanensis polyferose compound. The method is characterized in that low-molecular porphyran is used as a raw material and degraded by redox reaction to obtain low-molecular-weight porphyran with the molecular weight being less than 10000Da; and the polyferose compound synthesized by heating the porphyran and ferric chloride together can be dissolved well and exist stably under a physiological pH condition, and also shows a good effect in the iron-deficiency anemia mouse model experiment. The preparation method has the advantages of being simple and convenient in operation, stable in preparation process, low in preparation cost, etc.; and the preparation method also shows wide applicability to raw materials, namely, any polysaccharide with a proper molecular weight range is applicable to the preparation method.

Description

technical field [0001] The invention belongs to the field of marine medical health products, and in particular relates to a preparation method of a polysaccharide-iron complex using low-molecular laver polysaccharide as a raw material and its application in the treatment and prevention of iron-deficiency anemia. Background technique [0002] Iron deficiency anemia (DA) is one of the four most serious nutritional diseases in the contemporary world, seriously affecting human health. According to statistics published by the World Health Organization in 2002, 2 billion people around the world suffer from iron deficiency, and iron deficiency ranks ninth among the risk factors that seriously affect human health. According to statistics, the incidence rate of iron-deficiency anemia in my country is as high as 15%-20%, and about 200 million people in the country suffer from iron-deficiency anemia and iron malnutrition, among which women and children are high-risk groups. [0003] A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A23L1/09A61K31/715A61P7/06A23L33/125
Inventor 张忠山王晓梅
Owner HUZHOU TEACHERS COLLEGE
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