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Reagent for predicting micro-bleeding of acute cerebral infarction patient

A cerebral infarction and reagent technology, applied in the field of reagents for predicting the occurrence of microbleeds in patients with acute cerebral infarction, can solve the problems of low validation validity, accuracy and specificity, and achieve the effect of good predictive value

Inactive Publication Date: 2014-07-02
刘新峰
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AI Technical Summary

Problems solved by technology

[0008] How to predict whether microbleeds occur in patients with cerebral infarction, there is no definite method at present, there are only some clinical scoring scales, but the accuracy and specificity are not high, and its validity has not been verified in the Chinese population
There is currently no biochemical detection method that can predict the occurrence of microbleeds

Method used

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  • Reagent for predicting micro-bleeding of acute cerebral infarction patient

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Embodiment

[0022] 1 Materials and methods

[0023] 1.1 Research object

[0024] The subjects of the study were first-episode ischemic stroke patients who were hospitalized in Nanjing General Hospital of Nanjing Military Region from January 2012 to August 2012, and healthy volunteers with headache and dizziness during the same period served as the control group, all completed MRI (3.0T) Susceptibility sequence (SWI) scan. The degree of neurological deficit was scored by the National Institutes of Health Stroke Scale (NIHSS) by two neurologists who were blind to the results of imaging examinations. The inclusion criteria are as follows: (1) NIHSS score ≤ 8 points; (2) admitted to the hospital within 1 week of onset; (3) no contraindications for MRI examination (such as the presence of magnetic metal substances in the body). The exclusion criteria were as follows: (1) kidney or liver disease; (2) acute or chronic inflammatory diseases, such as pneumonia, meningitis, etc., and recent use o...

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Abstract

The invention belongs to the field of biological detection, and relates to a reagent for predicting micro-bleeding of an acute cerebral infarction patient. The reagent consists of reagents for detecting any one or more of adiponectin, E-selectin, S100B proteins and soluble advanced glycation end product receptors sRAGE. The content of the adiponectin, the E-selectin, the S100B proteins and the soluble advanced glycation end product receptors in the venous blood of the acute cerebral infarction patient is detected, so that the occurrence possibility of micro-bleeding of the patient is judged in an early stage, and a basis is provided for early intervention.

Description

technical field [0001] The invention belongs to the field of biological detection and relates to a reagent for predicting microbleeding in patients with acute cerebral infarction. Background technique [0002] Cerebral microhemorrhage is a subclinical damage to the brain parenchyma mainly characterized by tiny bleeding caused by microvascular lesions in the brain. On gradient-echo T2-weighted imaging, microhemorrhages appear as one or more punctate foci of signal loss, 2–5 mm in diameter, without surrounding edema. Histopathology confirmed that the loss of signal was mainly due to the deposition of hemosiderin due to the micro arteriolar blood extravasation of fibrohyalinosis. Studies have shown that cerebral microbleeds are related to age, cardiovascular risk factors, white matter degeneration, stroke, cerebral amyloid angiopathy, cognitive dysfunction, and post-stroke emotional disturbance. Cerebral microbleeds are associated with ischemic stroke and cerebral hemorrhage. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/53G01N2800/2871G01N2800/50
Inventor 叶瑞东朱武生刘新峰
Owner 刘新峰
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