Method for leaching and loading drug solution by using nanometer porous polylactic acid material

A polylactic acid material and nanoporous technology, which is applied in the fields of materials and chemicals, can solve the problems of low drug loading and limited drug loading efficiency of polylactic acid, and achieve the effects of large drug loading, high drug loading stability and simple process

Inactive Publication Date: 2014-07-09
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug loading efficiency of the existing disclosed methods is limited, and the drug loading per unit mass of polylactic acid is low

Method used

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  • Method for leaching and loading drug solution by using nanometer porous polylactic acid material
  • Method for leaching and loading drug solution by using nanometer porous polylactic acid material
  • Method for leaching and loading drug solution by using nanometer porous polylactic acid material

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0015] A method for drug loading using a drug solution of nanoporous polylactic acid material, comprising the following steps:

[0016] 1) The medical-grade polylactic acid with a molecular weight of 200,000 was made into a porous material by leaching NaCl salt particles. The scanning electron microscope picture is as follows: figure 1 As shown, the pore diameter is about 100 microns, and there are micropores and cracks of about 50-500 nanometers on the pore wall. Such as figure 2 shown.

[0017] 2) Immerse the microporous polylactic acid A obtained in step (1) in an aspirin solution with a concentration of 5 mol / L, rinse and soak for 3 hours, and the aspirin molecule B will attach to the surface micropores of the microporous polylactic acid A, as image 3 shown.

[0018] 3) The microporous polylactic acid is taken out from the drug solution, and vacuum-dried at room temperature for 30 minutes to obtain the microporous polylactic acid material loaded with aspirin.

Embodiment 2

[0020] 1) The medical-grade polylactic acid with a molecular weight of 500,000 is made into a porous material by leaching NaCl salt particles. The pore diameter is about 200 microns, and there are micropores and cracks about 200 nanometers on the pore wall.

[0021] 2) Immerse the microporous polylactic acid in a paclitaxel solution with a concentration of 1 mol / L, rinse and soak for 2 hours.

[0022] 3) The microporous polylactic acid is taken out from the drug solution, and vacuum-dried at room temperature for 30 minutes to obtain the paclitaxel-loaded microporous polylactic acid material.

[0023] 4) The foamy microporous polylactic acid is cold-pressed and granulated to make microspheres with a diameter of about 1 mm. The obtained microspheres are the sustained-release drug-loading materials of paclitaxel, which can be further used for medical purposes.

Embodiment 3

[0025] 1) The medical-grade polylactic acid with a molecular weight of 1 million is made into a porous material by leaching NaCl salt particles. The pore size is 10 microns, and there are micropores and cracks of 10 nanometers on the pore wall.

[0026] 2) Immerse the microporous polylactic acid in a paclitaxel solution with a concentration of 1 mol / L, rinse and soak for 2 hours.

[0027] 3) The microporous polylactic acid is taken out from the drug solution, and vacuum-dried at room temperature for 30 minutes to obtain the paclitaxel-loaded microporous polylactic acid material.

[0028] 4) The foamy microporous polylactic acid is cold-pressed and granulated to make microspheres with a diameter of about 1 mm. The obtained microspheres are the sustained-release drug-loading materials of paclitaxel, which can be further used for medical purposes.

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Abstract

The invention relates to a method for leaching and loading a drug solution by using a nanometer porous polylactic acid material. According to the method, a nanometer porous polylactic acid material is immersed in a drug solution to be loaded to render drugs enter nanometer holes and cracks of the inner surface of the micropores of the nanometer porous polylactic acid material, the drug loading of polylactic acid material carrier per unit volume is improved by using high specific surface area of microporous materials. Compared with the prior art, the nanometer porous polylactic acid material in the method has larger drug loading per unit volume, the drug is loaded without chemical treatment due to microporous physical absorption while the drug loading stability is high, the technology is simple, the processing conditions are mild, and the influence on the drug loading organism and the properties of the drug is small.

Description

technical field [0001] The invention belongs to the technical fields of materials and chemical engineering, and in particular relates to a drug-loading method using a drug solution of nanoporous polylactic acid materials. Background technique [0002] Polylactic acid (Polylactic Acid or Polylactide, abbreviation: PLA) is a bio-based polyester that is easily hydrolyzed. It has good biocompatibility, and the final degradation products are water and carbon dioxide, without biological toxicity. Therefore, polylactic acid is considered to be a potential medical material, and the use of polylactic acid as a drug carrier has been studied for many years at home and abroad. At present, there are many studies on the drug-loading process of polylactic acid, and the more common methods include chemical grafting, block, physical coating, and nano-microsphere encapsulation. However, the drug loading efficiency of the existing disclosed methods is limited, and the drug loading per unit m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/40C08L67/04
Inventor 万锕俊黄然
Owner SHANGHAI JIAO TONG UNIV
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