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Micro biochip for real-time detection of substances in body fluids

A microbiology, real-time detection technology, applied in the direction of laboratory containers, measuring devices, laboratory utensils, etc., can solve the problem of lack of real-time continuous analysis of microbiological chips, etc., to increase the detection signal density, smooth circulation, dead volume, fast response effect

Active Publication Date: 2014-07-09
BEIJING YICHENG BIOELECTRONICS TECHNOLOGY COMPANY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, in the prior art, there is a lack of miniature biochips that can be conveniently used for real-time and continuous analysis of substances in body fluids

Method used

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  • Micro biochip for real-time detection of substances in body fluids
  • Micro biochip for real-time detection of substances in body fluids
  • Micro biochip for real-time detection of substances in body fluids

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Implementation Example 1: Miniature Biochip with Single Detection Chamber and Single Sensor

[0056] see figure 1 , 3 and 5, a biochip with a single detection chamber and a single sensor 6 is used to continuously monitor various analytes in body fluids, such as blood glucose, lactic acid, sodium ions, calcium ions, magnesium ions, chloride ions, bicarbonate ions, and Various proteins and so on. It is assembled by a flow-through microfluidic chip 3 and a thin-film biosensor 4 . It can be used for the continuous detection of single analytes in body fluids.

[0057] flow-through microfluidic chip

[0058] see figure 1 , the microfluidic circuit of the flow-through microfluidic chip 3 is usually composed of the following parts: fluid inlet 301 , micropore 302 , serpentine channel 303 , detection chamber 310 , microchannel 306 , and fluid outlet 307 . The various parts of the flow-through microfluidic chip 3 are sequentially connected to each other to form a complete f...

Embodiment 2

[0067] Example 2: Biochip with multiple detection chambers and multiple sensors

[0068] see figure 2 , 4 and 6, the biochip 6 with multiple detection chambers and multiple sensors is used for continuous monitoring of various analytes in body fluids, such as blood sugar, lactic acid, sodium ions, calcium ions, magnesium ions, chloride ions, bicarbonate ions and body fluids Various proteins and so on. It is assembled by a flow-through microfluidic chip 3 and a thin-film biosensor 4 . It can be used to simultaneously and continuously detect multiple analytes in body fluids.

[0069] flow-through microfluidic chip

[0070] see figure 2 , the microfluidic circuit of flow-through microfluidic chip 3 is composed of the following parts: fluid inlet 301 , micropore 302 , serpentine channel 303 , detection chambers 310 and 311 , microchannels 304 , 305 and 306 , and fluid outlet 307 . Each part is sequentially connected through. form a complete fluid path. Each of the above-m...

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Abstract

The invention discloses a micro bio-chip for real-time detection of substances in body fluids, the micro bio-chip is assembled by a circulating microfluidic chip and a film biosensor, parts of the circulating microfluidic chip in turn are connected with each other to form a complete fluid pathway, and the film biosensor includes a working electrode, a counter electrode and a reference electrode; in a testing room of the circulating microfluidic chip, one or more film biosensors are embedded in the manner of series connection, or parallel connection / series connection and parallel connection, so that the surfaces of the embedded film biosensors are always contacted with the body fluid flowing by for real-time detection of the substances in the body fluids.

Description

technical field [0001] The invention relates to the field of microfluidic chips, in particular to a microbiological chip for real-time detection of substances in body fluids. Background technique [0002] In the clinical detection of body fluids, the miniaturized microdialysis system can overcome the disadvantages of large dead volume and long lag time of the traditional microdialysis system. For example, Gaspar uses a flow-through multi-sensor chip combined with a microdialysis system to continuously monitor glucose in body fluids: faster response speed and smaller dead volume; but there are no microfluidic control components in the microdialysis system, Very narrow dynamic response range, e.g., for glucose in blood less than 5 mM, see S Gaspar, X. Wang, H. Suzukib, E. Csoregi, Amperometric biosensor-based flow-through microdetector for microdialysis applications, Analytica Chimica Acta525 (2004) 75–82). [0003] The wearable blood glucose meter device adopts reverse iont...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26
CPCG01N33/4915B01L3/5027B01L2300/0636
Inventor 莫健伟李元光何伟李献红王官俊杨轶颖
Owner BEIJING YICHENG BIOELECTRONICS TECHNOLOGY COMPANY
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