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Nanometer cobaltous oxide doped micronomicin molecular imprinting electrochemical sensor with high sensitivity and preparation method of sensor

A technology of nano-cobalt oxide and small Nomi star, applied in the direction of electrochemical variables of materials, etc., can solve the problems of poor cross-linking rigidity, low sensitivity, inappropriate matching of functional monomers with template molecules and cross-linking agents, etc.

Inactive Publication Date: 2014-07-16
GUANGXI UNIV FOR NATITIES
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  • Abstract
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Problems solved by technology

The current method is not sensitive due to the inappropriate matching of selected functional monomers with template molecules and cross-linking agents, and the rigidity of cross-linking is also poor.

Method used

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  • Nanometer cobaltous oxide doped micronomicin molecular imprinting electrochemical sensor with high sensitivity and preparation method of sensor

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Embodiment 1

[0014] 1. Treatment of glassy carbon electrodes

[0015] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in sequence, then put it into nitric acid with a volume ratio of 1:1 for 6 minutes, then put it into absolute ethanol for 6 minutes, and finally Ultrasonic cleaning with pure water.

[0016] 2. Preparation of molecularly imprinted electrochemical sensor for paracetamol

[0017] To 10.0mL solvent ethanol, add 0.4mmol template molecule small nominacin, 2.0mmol20(s)-O-3β-hydroxy-5-androstene-17β-acylcamptothecin functional monomer, 4.0mmol Mmol crosslinking agent maleic rosin ethylene glycol acrylate, 0.8mmol initiator azobisisobutyronitrile and 0.0200g of nano-cobalt oxide, each adding a chemical reagent ultrasonically dissolved for 8 minutes;

[0018] Take 8 μL of the mixture in step and apply it on the surface of a clean and smooth glassy carbon electrode. After standing for 8 hours, place the modified electrode in...

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Abstract

The invention discloses a nanometer cobaltous oxide doped micronomicin molecular imprinting electrochemical sensor with the high sensitivity and a preparation method of the sensor. The preparation method is characterized in that micronomicin is utilized as a template molecule, 20(s)-O-3beta-hydroxyl-5-androstene-17beta-acyl camptothecin is utilized as a functional monomer, azodiisobutyronitrile is utilized as an initiator, nanometer cobaltous oxide is utilized as a doping agent, and maleated rosin crylic acid gylcol ester which is compounding by taking rosin as a raw material is utilized as a cross-linking agent, so that the nanometer cobaltous oxide doped micronomicin molecular imprinting electrochemical sensor with the high sensitivity is prepared, an analytical method is simple and practical, and the disadvantages that an existing analytical method is complex, equipment is expensive, and the sensitivity is low are overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a high-sensitivity nanometer cobalt oxide-doped small nomistar molecularly imprinted electrochemical sensor and a preparation method thereof. Background technique [0002] Indications for Nomicin: It is suitable for the treatment of respiratory tract infection, urinary tract infection (urinary tract infection), abdominal cavity infection and trauma infection caused by sensitive bacteria, and can also be used for the treatment of sepsis. However, long-term use or overdose of these drugs can cause dizziness, tinnitus, and renal and hepatic insufficiency. [0003] The methods for determining Minor Nomicin include high-performance liquid chromatography, chromatography-mass spectrometry, and the like. However, due to the need for expensive instruments and equipment, these methods have disadvantages such as high cost, long time-consuming, and low sensitivity. Therefor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30
Inventor 谭学才雷福厚李浩韦贻春余会成陈其锋
Owner GUANGXI UNIV FOR NATITIES
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