A kind of pharmaceutical composition for reducing blood uric acid level and application thereof

A technology of blood uric acid and level, applied in the field of natural medicine, can solve the problem of not finding carboxymethyl tuckahoe polysaccharide to reduce blood uric acid level, etc., and achieve the effects of reducing gout, reducing uric acid, and promoting uric acid excretion

Inactive Publication Date: 2016-10-05
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] By searching the domestic and foreign literature, there is no literature report that carboxymethylpachyan can reduce blood uric acid level

Method used

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  • A kind of pharmaceutical composition for reducing blood uric acid level and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of embodiment 1 carboxymethylpachyan (CMP)

[0016] 1) 7.5kg of dried poria cocos was crushed, sieved with an 80-mesh sieve, the poria cocos powder was taken, put into a soaking tank, pumped into 60L of water, stirred evenly, and soaked for 12 hours;

[0017] 2) Prepare 40L of 2.5mol / L sodium hydroxide solution in a glass-lined preparation tank;

[0018] 3) Slowly pump the lye in step 2) into 1), stir evenly, extract for 1.5 hours, press filter, and the filtrate is directly introduced into the glass-lined reaction tank through the pipeline;

[0019] 4) Prepare 50 L of 3.2 mol / L chloroacetic acid solution in a glass-lined neutralization tank;

[0020] 5) Prepare 2.5 mol / L sodium hydroxide solution in a glass-lined preparation tank; cool it, and slowly pump it into step 4) for neutralization reaction, stir evenly, cool down, then pump it into a glass-lined reaction tank, and stir evenly , slowly heating up to 59°C, and reacting at constant temperature fo...

Embodiment 2

[0038] Example 2 Experimental Study of Carboxymethyl Pachyphyllan on Lowering Blood Uric Acid in Rats

[0039] Thirty-four SPF grade healthy male SD rats, weighing 180-220g, were randomly divided into the following three groups according to body weight: normal control group (10 rats), model group (12 rats), and treatment group (12 rats). The normal control group was fed with common feed, and the model control group and treatment group were given high-yeast feed (20% yeast extract + 80% basic feed) + 200 mg / kg potassium oxonate by intragastric administration to prepare hyperuricemia models; While establishing the model, 8 mg / (kg d) of carboxymethylpachyran was injected into the tail vein (administration volume 0.5 ml / 100 g once a day), and the normal control group and the model control group were injected with the same amount of water for injection through the tail vein. . Continuous administration for 6 weeks.

[0040] At the end of the 0th, 2nd, 4th, and 6th weeks of medica...

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Abstract

The invention discloses a pharmaceutical composition for reducing the level of blood uric acid and an application thereof. The composition is prepared from active components and auxiliary materials, wherein the active components comprise carboxymethyl pachymaran or / and derivatives thereof. The pharmaceutical composition has the effect of promoting excretion of uric acid and reducing uric acid and can prevent or delay occurrence and development of hyperuricemia so as to reduce occurrence of gout, hypertension, cardiovascular diseases and kidney diseases.

Description

technical field [0001] The invention belongs to the technical field of natural medicines, and in particular relates to a pharmaceutical composition for reducing blood uric acid level and application thereof. Background technique [0002] With the acceleration of the pace of life, people's living standards are improving, exercise time is decreasing, and the incidence of hyperuricemia is on the rise. The pathogenesis of hyperuricemia is caused by excessive production of uric acid or renal excretion disorder due to purine metabolism disorder, and its serious consequences can lead to gouty arthritis, uric acid kidney damage and cardiovascular damage. At present, there are few effective, safe and economical drugs for lowering blood uric acid, and some drugs that promote uric acid excretion or xanthine oxidase inhibitors can cause gastrointestinal side effects, inhibition of bone marrow hematopoietic function, kidney toxicity and allergies, etc. Clinical symptoms, these side effe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61P19/06
Inventor 葛均华李健于海初廉哲勋
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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