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Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, as well as preparation method and application thereof

A technology for cardiovascular and cerebrovascular diseases and compositions, which is applied in cardiovascular system diseases, drug combinations, pharmaceutical formulations, etc., can solve the problems of single target, unsuitable for the prevention and treatment of cerebral infarction, and achieve the effect of enhancing blood circulation and removing blood stasis.

Active Publication Date: 2014-07-30
SICHUAN CHUANDA WEST CHINA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The treatment of multiple cerebral infarction with western medicine has the advantages of rapid onset of effect and strong therapeutic pertinence, and it is mostly used in the acute phase as the main treatment. However, simultaneous blood and blood vessel lesions are the root cause of multiple cerebral infarction; moreover, most western medicines have obvious side effects and drug resistance. Even aspirin, the basic clinical drug for multiple cerebral infarction, will produce 47% drug resistance. Therefore, alone Taking western medicine is not suitable for long-term prevention and treatment of multiple cerebral infarction

Method used

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  • Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, as well as preparation method and application thereof
  • Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, as well as preparation method and application thereof
  • Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: pharmaceutical composition pill of the present invention

[0032] Weigh 500.00g of Danshen, 260.50g of Rhizoma Chuanxiong, 260.50g of Radix Paeoniae Rubra, 260.50g of Safflower, 120.75g of Rhizoma Cyperi, 120.75g of Ginkgo biloba, 120.75g of Muxiang, and 70.40g of Hawthorn. Crush safflower, red peony and ginkgo leaves into coarse powder, sieve, and mix well. Mix the other four medicinal materials such as Salvia miltiorrhiza, add water to decoct three times, add 10 times the amount of water for the first time, and 8 times the amount for the second and third times, decoct for 1 hour each time, filter, and the filtrate is heated at 45-50 ° C. Concentrated at low temperature to a clear paste with a relative density of 1.10-1.30. Add safflower, red peony, ginkgo leaves and other coarse powders to the clear paste, mix well, dry, crush into fine powder, pour pills with appropriate amount of distilled water, dry and polish. A total of 1000 g pellets were made. ...

Embodiment 2

[0033] Embodiment 2: pharmaceutical composition oral liquid of the present invention

[0034] Weigh 450.00g of Danshen, 250.50g of Rhizoma Chuanxiong, 250.50g of Radix Paeoniae Rubra, 250.50g of Safflower, 125.75g of Rhizoma Cyperi, 125.75g of Ginkgo biloba, 125.75g of Muxiang, and 60.40g of Hawthorn. Mix the medicinal materials, add water and decoct three times, add 10 times the amount of water for the first time, and 8 times the amount for the second and third times, decoct for 1 hour each time, filter, and put the filtrate in a centrifugal thin film evaporator at a low temperature of 45-50 ℃ Concentrated to a clear paste with a relative density of 1.10-1.30. Add 300ml of 60% simple syrup and 1.5g of sodium benzoate to the obtained clear paste, adjust the pH value to 5.0, add distilled water to adjust the total amount to 1000ml, stir well, filter, pot, and sterilize with steam for 30min to obtain .

Embodiment 3

[0035]Embodiment 3: pharmaceutical composition granule of the present invention (Le Mai granule side adds Ginkgo biloba composition granule)

[0036] Weigh 490.00g of Danshen, 249.50g of Rhizoma Chuanxiong, 249.50g of Radix Paeoniae Rubra, 249.50g of Safflower, 124.75g of Rhizoma Cyperi, 124.75g of Ginkgo biloba, 124.75g of Muxiang, and 62.40g of Hawthorn. Mix the medicinal materials, add water and decoct three times, add 10 times the amount of water for the first time, and 8 times the amount for the second and third times, decoct for 1 hour each time, filter, and put the filtrate in a centrifugal thin film evaporator at a low temperature of 45-50 ℃ Concentrated to a clear paste with a relative density of 1.10-1.30. Fluidize the obtained clear paste with lactose in a batch fluidized bed, dry, add 85% ethanol soft material, pass through a 20-mesh sieve to make wet granules, dry the wet granules at 60-70°C, and dry the granules for Sieve through a 20-mesh sieve, make 1000g, and...

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Abstract

The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases. The pharmaceutical composition is a preparation prepared from the following raw medicines in parts by weight: 300 to 700 parts of salvia miltiorrhiza, 100 to 400 parts of ligusticum wallichii, 100 to 400 parts of radix paeoniae rubra, 100 to 400 parts of flowers carthami, 50 to 200 parts of nutgrass galingale rhizome, 50 to 200 parts of folium ginkgo, 50 to 200 parts of radix aucklandiae, and 20 to 100 parts of hawthorn. The invention also provides a preparation method and application of the pharmaceutical composition. According to the preparation method, the pharmaceutical composition is prepared on the basis of the formula of Lemai granula (traditional Chinese medicine granula) for tonifying Qi and promoting blood circulation to remove blood stasis, and activating Qi, dredging collaterals and relieving pain; folium ginkgo is added to improve the effect of promoting blood circulation to remove blood stasis; in addition, the treatment effect of the pharmaceutical composition is obviously superior to that of Lemai granula; the pharmaceutical composition brings a new choice for clinical medicines used for treating multiple cerebral infarction and coronary heart disease angina.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases. Background technique [0002] my country is a country with a high incidence of cerebrovascular diseases. With the continuous improvement of people's material living standards and the increase of the aging population, the incidence is rapidly increasing. Cerebrovascular diseases seriously affect human health with high morbidity, high disability and high death rate, and the incidence of multiple cerebral infarction accounts for a considerable proportion. [0003] Multiple cerebral infarction refers to multiple ischemic softening infarcts in the brain, also known as multiple encephalomalacia, accompanied by paralysis, sensory and language barriers, and dementia may also occur. The sequelae of cerebral infarction are common hemiplegia, crooked mouth and eyes, slurred speech, drooling at the corners of the mouth, limb edema, numbness, pain, fear ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8905A61P9/10
Inventor 刘娅聂阳姚喆姚万龙焦豪妍何盛江张现涛
Owner SICHUAN CHUANDA WEST CHINA PHARMA
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