Application of 3-(2-aminoethylamino)propyltrimethoxysilane to prepare ultra-bright fluorescent silicon quantum dots

A technology of propyltrimethoxysilane and aminoethylamino, applied in the application field of 3-propyltrimethoxysilane in the preparation of water-soluble high-brightness fluorescent silicon quantum dots, can solve the problem of not having pH response characteristics, quantum Low yield and other problems, to achieve the effect of good water solubility, high quantum yield, and low cytotoxicity

Active Publication Date: 2014-08-27
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the silicon quantum dots prepared by the above two methods are all based on "3-aminopropyltrimethoxysiloxane (APTMS)" silane as raw material, and its quantum yield is

Method used

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  • Application of 3-(2-aminoethylamino)propyltrimethoxysilane to prepare ultra-bright fluorescent silicon quantum dots
  • Application of 3-(2-aminoethylamino)propyltrimethoxysilane to prepare ultra-bright fluorescent silicon quantum dots
  • Application of 3-(2-aminoethylamino)propyltrimethoxysilane to prepare ultra-bright fluorescent silicon quantum dots

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of water-soluble high-brightness fluorescent silicon quantum dots comprises the following steps:

[0033] (1) Be that the mass fraction is 4.65% sodium citrate solution, pass into nitrogen 5min, remove the oxygen in the solution;

[0034] (2) Add 3-(2-aminoethylamino)propyltrimethoxysilane while stirring, and stir for 10min in a closed state to form a silicon quantum dot precursor solution; 3-(2-aminoethylamino) The mass ratio of propyltrimethoxysilane to sodium citrate aqueous solution is 20:80;

[0035] (3) React in a microwave reactor at 160° C. for 15 minutes to form a silicon quantum dot solution;

[0036] (4) Dialyzing the silicon quantum dot solution with a dialysis bag with a molecular weight of 1000 to obtain a pure silicon quantum dot solution.

[0037] Wherein the structural formula of "3-(2-aminoethylamino) propyltrimethoxysilane" is as follows:

[0038]

[0039] Measuring its fluorescence intensity: adjust the pH value of the silicon q...

Embodiment 2

[0041] The preparation of water-soluble high-brightness fluorescent silicon quantum dots comprises the following steps:

[0042] (1) feed nitrogen into the 3% sodium citrate solution for 10 minutes to remove the oxygen in the solution;

[0043] (2) Add 3-(2-aminoethylamino)propyltrimethoxysilane while stirring, and stir for 10min in a closed state to form a silicon quantum dot precursor solution; 3-(2-aminoethylamino) The mass ratio of propyltrimethoxysilane to sodium citrate aqueous solution is 10:80;

[0044] (3) React in a microwave reactor at 150° C. for 10 minutes to form a silicon quantum dot solution;

[0045] (4) Dialyzing the silicon quantum dot solution with a dialysis bag with a molecular weight of 1000 to obtain a pure silicon quantum dot solution.

[0046] Its fluorescence intensity is basically consistent with Example 1.

Embodiment 3

[0048] The preparation of water-soluble high-brightness fluorescent silicon quantum dots comprises the following steps:

[0049] (1) feed nitrogen gas into the 6% sodium citrate solution for 8 minutes to remove the oxygen in the solution;

[0050] (2) Add 3-(2-aminoethylamino)propyltrimethoxysilane while stirring, and stir for 5min in a closed state to form a silicon quantum dot precursor solution; 3-(2-aminoethylamino) The mass ratio of propyltrimethoxysilane to sodium citrate aqueous solution is 30:80;

[0051] (3) React in a microwave reactor at 170° C. for 3 minutes to form a silicon quantum dot solution;

[0052] (4) Dialyzing the silicon quantum dot solution with a dialysis bag with a molecular weight of 1000 to obtain a pure silicon quantum dot solution.

[0053] Its fluorescence intensity is basically consistent with Example 1.

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Abstract

The invention provides application of 3-(2-aminoethylamino)propyltrimethoxysilane to prepare ultra-bright fluorescent silicon quantum dots. The novel silicane molecule 3-(2-aminoethylamino)propyltrimethoxysilane is applied to prepare silicon quantum dots, and the prepared silicon quantum dots have the advantages of high quantum-dot yield (about 80%), high purity, good stability, good water solubility, pH response property, surface chemical paintability, low cell toxicity, synthesis simpleness and the like.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and particularly relates to the application of 3-(2-aminoethylamino)propyltrimethoxysilane in the preparation of water-soluble high-brightness fluorescent silicon quantum dots. Background technique [0002] Silicon quantum dots are a typical zero-dimensional nanomaterial with a size of 2-4nm. They have the characteristics of good water solubility, stable optical properties, high fluorescence intensity, and easy functional modification. At the same time, due to their good biological Compatibility, low biological toxicity and other advantages, so it has broad biological and biomedical application prospects. Traditional organic fluorescent dyes are not suitable for long-term, real-time biological imaging due to their poor resistance to photobleaching. Silicon quantum dots have good anti-photobleaching properties, which can solve this problem well. [0003] At present, there are two mai...

Claims

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Application Information

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IPC IPC(8): C01B33/021C09K11/79
Inventor 吴富根开思琪陈战
Owner SOUTHEAST UNIV
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