New use of penthorum chinense pursh or extract thereof

A technology of rushing yellow grass and extract, which is applied in the field of new use of yellow grass or its extract to achieve good preventive or therapeutic effects, improve HDL-C level, and reduce TG level.

Inactive Publication Date: 2014-09-03
四川古蔺肝苏药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • New use of penthorum chinense pursh or extract thereof
  • New use of penthorum chinense pursh or extract thereof
  • New use of penthorum chinense pursh or extract thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 The preparation method of the extract of C. japonica of the present invention:

[0029] (1) Extraction: Take the medicinal material of Quhuangcaojing, cut it into sections of 5-10cm, put it into the extraction tank, add 4-8 times the amount of water, heat to boiling and extract for 2-4 hours, filter, and enter the medicinal liquid into the medicinal liquid storage tank ; Add 2-4 times the amount of water for the second time, boil and decoct for 2-4 hours, filter, and combine the filtrate with the first time;

[0030] (2) Concentration: Vacuum concentration to a water-clear paste with a relative specific gravity (60-70°C) of 1.15-1.18.

[0031] (3) Alcohol precipitation: Add ethanol to Shuiqing ointment to make the alcohol content of the medicinal solution reach 50-70%, stir evenly, stop stirring and let the medicinal solution stand still until the precipitation is complete, extract the supernatant of alcohol precipitation, and wash the precipitate , combine t...

Embodiment 2

[0033] Embodiment 2 The preparation method of the extract of C. japonica of the present invention:

[0034](1) Extraction: Take the medicinal material of Quhuangcaojing, cut it into 5-10cm sections, put it into the extraction tank, add 8-10 times the amount of water, heat to boiling and extract for 1-3 hours, filter, and enter the liquid medicine storage tank ; Add 5-7 times the amount of water for the second time, boil and decoct for 1-3 hours, filter, and combine the filtrate with the first time;

[0035] (2) Concentration: Vacuum concentration to a water-clear paste with a relative specific gravity (60-70°C) of 1.18-1.20.

[0036] (3) Alcohol precipitation: Add ethanol to Shuiqing ointment to make the alcohol content of the medicinal solution reach 60-70%, stir evenly, stop the stirring and let the medicinal solution stand still until the precipitation is complete, extract the alcohol precipitation supernatant, and wash the precipitate , combine the supernatant with the wa...

Embodiment 3

[0037] Example 3 The preparation method of the extract of C. japonica of the present invention:

[0038] (1) Extraction: Take the medicinal material of Quhuangcaojing, cut it into sections of 5-10cm, put it into the extraction tank, add 10-12 times the amount of water, heat to boiling and extract for 1-2 hours, filter, and enter the medicinal liquid into the medicinal liquid storage tank ; Add 2-4 times the amount of water for the second time, boil and decoct for 2-4 hours, filter, and combine the filtrate with the first time;

[0039] (2) Concentration: Vacuum concentration to a water-clear paste with a relative specific gravity (60-70°C) of 1.13-1.15.

[0040] (3) Alcohol precipitation: Add ethanol to Shuiqing ointment to make the alcohol content of the medicinal solution reach 50-70%, stir evenly, stop stirring and let the medicinal solution stand still until the precipitation is complete, extract the supernatant of alcohol precipitation, and wash the precipitate , combine...

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Abstract

The invention provides a use of penthorum chinense pursh or an extract thereof in preparing health-care products or medicines for preventing or treating non-alcoholic fatty liver disease. Study indicates that the penthorum chinense pursh and the extract thereof have excellent prevention or treatment effect on the non-alcoholic fatty liver disease, and are capable of effectively reducing the ALT (Alanine Aminotransferase) level and the TBIL (Total Bilirubin) level in blood serum, reducing the TG (Triglyceride) level in the blood serum, increasing the HDL-C (High-Density Lipoproteincholesterol) level in the blood serum, reducing the TG and NEAF (Non-Esterified Fatty Acid) contents in the liver tissue, improving the GSH-PX (Glutathione Peroxidase) activity and relieving liver fatty degeneration, and therefore, a new option is provided for clinical medication for treating the non-alcoholic fatty liver disease.

Description

technical field [0001] The present invention relates to the new use of Herba Grass or its extract. Background technique [0002] Nonalcoholic fatty liver disease (NAFI.D) is a metabolic stress-induced liver injury closely related to insulin resistance (IR) and genetic susceptibility, and its pathological changes are similar to those of alcoholic liver disease. Similar to (alcoholic liver disease ALD), but the patient has no history of excessive drinking, the disease spectrum includes nonalcoholic simple fatty liver (nonalcoholic simple faay liVet, NAFL), nonalcoholic steatohepatitis (nonalcoholic steatohepatitis, NASH) and its related cirrhosis and liver cell carcinoma. [0003] In the clinical diagnosis, the following three conditions must be met for a definite diagnosis of NAFLD: (1) no history of alcohol consumption or equivalent alcohol consumption <140g / week (for women <70g / week); (2) exclusion of viral hepatitis, drug-induced liver disease, Total parenteral nut...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/16A61P3/06
CPCA61K36/185
Inventor 江云张大永兰泽伦刘静张莉祁杰
Owner 四川古蔺肝苏药业有限公司
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