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Thermosensitive hydrogel and preparation method and application thereof

A temperature-sensitive hydrogel and lactide technology, applied in the field of medicine, can solve the problems of melanin diffusion, unclear labeling, and inconspicuous uplift effects, and achieve the effects of preventing diffusion, increasing accuracy, and reducing the risk of bleeding

Active Publication Date: 2016-08-10
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The marker used in ESD surgery is a hypertonic glycerol-fructose solution added with melanin marker. During the operation, melanin is prone to spread, the mark is not clear, and the swelling effect is not obvious.

Method used

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  • Thermosensitive hydrogel and preparation method and application thereof
  • Thermosensitive hydrogel and preparation method and application thereof
  • Thermosensitive hydrogel and preparation method and application thereof

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preparation example Construction

[0030] The preparation method of PLGA-PEG-PLGA triblock copolymer of the present invention comprises the following steps:

[0031] (1) After mixing PEG1000 and PEG1500 in a certain mass ratio, reflux under vacuum at a suitable temperature for 2 to 4 hours to remove the water in PEG1000 and PEG1500;

[0032] (2) Add lactide and glycolide, and heat it to 80-100°C for 5-20 minutes at an external temperature under vacuum conditions until the solid dissolves. The mass ratio of the added lactide to glycolide is 2-4: 1. The mass ratio of the sum of lactide and glycolide to the total amount of PEG is 1-2:1;

[0033] (3) After cooling to room temperature, add the catalyst, use a reflux condensing device to react at an external temperature of 120-160°C for 6-12 hours, stop heating and vacuumize for 20-40 minutes, and cool to room temperature to obtain the product PLGA-PEG-PLGA triembedded segment copolymers.

[0034] Preferably, after step (3), the following step (4) is also included:...

Embodiment 1

[0042] This embodiment prepares PLGA-PEG-PLGA triblock copolymer, comprises steps as follows:

[0043] (1) Add polyethylene glycol 1000 (PEG1000) and polyethylene glycol 1500 (PEG1500) into the three-necked bottle at a mass ratio of 1:1, and at a speed of 200r / min, the oil pump controls the vacuum at -0.1 MPa, external temperature 145°C, internal temperature 130°C, vacuum cold water reflux for 2 hours, remove a small amount of water in PEG1000 and PEG1500;

[0044] (2) Then cool to room temperature with high-purity nitrogen, add lactide (LA) and glycolide (GA), so that the ratio of LA / GA is 2:1, and the ratio of (LA+GA) / PEG is 1:1 , heat the external temperature to 100°C for 5 minutes under vacuum conditions until the solid dissolves;

[0045] (3) Cool to room temperature with nitrogen gas, add the catalyst stannous octoate, install a reflux condensing device, and react at an external temperature of 120°C for 6 hours, the reaction solution is light yellow and clear, stop heat...

Embodiment 2

[0049] This embodiment prepares PLGA-PEG-PLGA triblock copolymer, comprises steps as follows:

[0050] (1) Add polyethylene glycol 1000 (PEG1000) and polyethylene glycol 1500 (PEG1500) into the three-necked bottle at a mass ratio of 1:1, and at a speed of 200r / min, the oil pump controls the vacuum at -0.1 MPa, external temperature 145°C, internal temperature 130°C, vacuum cold water reflux for 3 hours, remove a small amount of water in PEG1000 and PEG1500;

[0051] (2) Then fill with high-purity nitrogen and cool to room temperature, add lactide (LA) and glycolide (GA), so that the ratio of LA / GA is 2.5:1, and the ratio of (LA+GA) / PEG is 2:1 , heat the external temperature to 90°C for 10 minutes under vacuum conditions until the solid dissolves;

[0052] (3) Cool to room temperature with nitrogen gas, add the catalyst stannous octoate, install a reflux condensing device, react at an external temperature of 142°C for 8 hours, the reaction solution is light yellow and clear, st...

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Abstract

The invention discloses a temperature-sensitive hydrogel, which is a PLGA-PEG-PLGA triblock copolymer, wherein the mass ratio of lactide to glycolide in the PLGA copolymer is 2-4:1, the The mass ratio of the sum of lactide and glycolide to the mass of PEG is 1-2:1. The invention also discloses a preparation method of the thermosensitive hydrogel and its application in endoscopic submucosal dissection. The temperature-sensitive hydrogel of the present invention, when used as a marker carrier in endoscopic submucosal dissection, can increase the height of the mucosal bulge and prevent the diffusion of markers in the submucosa, thereby ensuring complete cutting during endoscopic submucosal dissection , reduce the risk of perforation and bleeding, improve the safety and efficiency of surgery, and reduce the pain of patients.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a temperature-sensitive hydrogel and its preparation method and application. Background technique [0002] Polylactic acid-polyethylene glycol-polylactic acid (PLGA-PEG-PLGA) triblock copolymer, after in vivo injection, due to temperature changes, the copolymer solution changes from the original solution to a semi-solid gel. At the same time, PLGA-PEG-PLGA has biocompatibility and biodegradability, because its synthetic raw materials and their degradation products lactic acid, glycolic acid, and PEG are normal metabolites in the human body, so they have good biocompatibility; There is no need to use organic solvents in the purification process, which solves the problem of organic solvent residues encountered in the extraction process of various similar polymer compounds before, and reduces the organic solvent pollution and flammable and explosive problems in the production proce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L67/04C08G63/664C08J3/075A61K49/00A61K47/34
Inventor 高申张敏朱全刚金震东刘青青高静施新岗刘枫刘继勇王晓宇张丽娟戴子渊台宗光高原顾芬芬胡楚玲宫春爱夏清明
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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