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Composition for preparing modified starch matrix-containing hard capsule

A technology of modified starch and composition, which can be used in capsule delivery, medical preparations of non-active ingredients, applications, etc. It can solve the problems of low market share, high strength, and long capsule disintegration time, and achieve the purpose of inhibiting starch retrogradation , good flexibility effect

Active Publication Date: 2014-09-24
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the price of hydroxypropyl methylcellulose is not very expensive, the disintegration time of capsules prepared with it as the main raw material is relatively long, so its current market share is not high
The price of starch is very low, and it is very attractive to prepare hard capsules. Many domestic manufacturers have also applied for patents for starch capsules. However, because starch molecules are easy to form strong hydrogen bonds, the starch film is brittle and fragile, and it is difficult to produce starch capsules. Produces strong, filling-resistant capsules
Therefore, although there are many patents, it is difficult to form a product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Mixing 95wt% of modified starch (containing only 1.0wt% acetyl group) and 5wt% of carrageenan as a base is a composition for preparing hard capsules containing a modified starch base.

[0024] The composition obtained above was prepared into hard capsules by a conventional capsule preparation process. The prepared hard capsules were prepared with reference to the method specified in Part Two of the Chinese Pharmacopoeia 2010 Edition, and the friability was detected by polytetrafluoroethylene weights. 50 samples were crushed No more than 3 capsules, and its friability can meet the requirements of the Pharmacopoeia.

Embodiment 2

[0026] After mixing 80wt% modified starch (containing 2.5wt% acetyl group and 6.5wt% hydroxypropoxyl group), 15wt% locust bean gum, 0.1wt% potassium chloride and 4.9wt% sucrose as the base A composition for the preparation of hard capsules comprising a matrix of modified starch is obtained.

[0027] The composition obtained above was prepared into hard capsules by a conventional capsule preparation process. The prepared hard capsules were prepared with reference to the method specified in Part Two of the Chinese Pharmacopoeia 2010 Edition, and the friability was detected by polytetrafluoroethylene weights. 50 samples were crushed No more than 3 capsules, and its friability can meet the requirements of the Pharmacopoeia.

Embodiment 3

[0029] After mixing 55wt% modified starch (containing 2.5wt% acetyl group and 5.5wt% hydroxypropoxyl group), 40wt% pectin, 0.2wt% calcium chloride and 4.8wt% sorbitol as a base A composition for the preparation of hard capsules comprising a matrix of modified starch is obtained.

[0030] The composition obtained above was prepared into hard capsules by a conventional capsule preparation process. The prepared hard capsules were prepared with reference to the method specified in Part II of the Chinese Pharmacopoeia 2010 Edition, and the friability was detected by polytetrafluoroethylene weights. 50 samples were crushed No more than 3 capsules, and its friability can meet the requirements of the Pharmacopoeia.

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Abstract

The invention relates to a composition for preparing a modified starch matrix-containing hard capsule, which relates to the food and medicine fields. The composition for preparing the modified starch matrix-containing hard capsule comprises 55-95wt% of modified starch and 5-45wt% of gellant as matrix; and the modified starch is the modified starch containing 1-2.5wt% of acetyl and 0-6.5wt% of hydroxyl propoxy. The modified starch matrix-containing hard capsule is capable of performing molecular chain modification on the starch matrix, a steric group is introduced on the starch molecule and then hydrophobic modification is carried out, intermolecular hydrogen bond force of starch is overcome, so that the modified starch matrix-containing hard capsule has toughening enhancement effect; a tridimensional net structure is constructed by adding a composite plant gelatinizing agent, so that toughening and plasticising effects are generated, and thereby hard capsule with good flexibility can be prepared.

Description

technical field [0001] The invention relates to a composition for preparing hard capsules containing a modified starch matrix, which is used in the fields of food, medicine and the like. Background technique [0002] Capsules made from animal-derived gelatin have been around for at least 200 years. Since gelatin can mask the bad taste, smell or irritation to the stomach of many medicines, gelatin capsules are quickly promoted and used in the production of various solid preparations. Over the past 100 years, various capsules made of gelatin have been sold well in the international pharmaceutical market for a long time. At the end of the last century, the outbreak of mad cow disease finally dragged gelatin capsules into an unprecedented crisis of confidence. In April 2012, the "poisonous capsule" incident that broke out in my country undoubtedly aggravated the distrust of the Chinese people towards gelatin capsules. In addition, gelatin capsules themselves have many disadva...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36A23P1/04A23P10/30
Inventor 袁国卿闫丰文
Owner INST OF CHEM CHINESE ACAD OF SCI
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