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Method for detecting calcium-zinc content of calcium zinc gluconate granules

A technology of calcium zinc gluconate and calcium gluconate, applied in the field of drug analysis, can solve the problems of poor judgment of the end point, inability to effectively detect the content of calcium gluconate and zinc gluconate, and unclear end point indication.

Inactive Publication Date: 2014-09-24
GUIZHOU LIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Considering the bias and subjectivity of the judgment of the titration end point by the volumetric method, and the mutual influence of calcium gluconate and zinc gluconate in the prescription, it will also have a great impact on the measurement results
[0006] Take calcium zinc gluconate granules and measure calcium gluconate according to the standard of calcium zinc gluconate oral liquid. The color should change from purple red to pure blue, but the end point indication is not obvious. It is a gradual process, from red to purple, and finally to blue. It is blue, so the end point is not easy to judge
[0007] Take calcium zinc gluconate granules and measure zinc gluconate according to the standard of calcium zinc gluconate oral liquid. The color should change from red to yellow, but the end point indication is not obvious. It turns yellow, so the end point is not easy to judge
[0008] It can be seen that the determination method in the calcium zinc gluconate oral liquid standard is not suitable for calcium zinc gluconate granules, and cannot effectively detect the content of calcium gluconate and zinc gluconate

Method used

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  • Method for detecting calcium-zinc content of calcium zinc gluconate granules
  • Method for detecting calcium-zinc content of calcium zinc gluconate granules
  • Method for detecting calcium-zinc content of calcium zinc gluconate granules

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Embodiment Construction

[0028] (1) Determination of zinc gluconate content, including the following operations:

[0029] According to the atomic absorption spectrophotometry (Chinese Pharmacopoeia 2010 edition two appendix IVD first method) determination.

[0030] Preparation of reference solution Precisely measure 1ml of 1000μg / ml zinc standard solution, put it in a 100ml measuring bottle, dilute to the mark with nitric acid solution (1→100), shake well, and use it as the reference solution.

[0031] Preparation of the test solution Weigh about 0.28g of calcium zinc gluconate particles (approximately equivalent to 8.4mg of zinc gluconate), a total of 6 parts, accurately weighed, put in a 100ml measuring bottle, add an appropriate amount of nitric acid solution and shake to dissolve and Dilute to the mark, shake well, accurately measure 2ml, put it in a 50ml measuring bottle, dilute to the mark with nitric acid solution, shake well, and get ready.

[0032] Determination method Precisely measure 3.0,...

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Abstract

The invention discloses a method for detecting the calcium gluconate content and zinc gluconate content of calcium zinc gluconate granules. Atomic absorption spectrophotometry is adopted. According to the method, the calcium gluconate content and the zinc gluconate content can be effectively detected; the method is high in durability, recovery rate, precision and stability, and interference between calcium and zinc is avoided.

Description

technical field [0001] The invention belongs to the technical field of drug analysis, in particular to a method for detecting the contents of calcium gluconate and zinc gluconate in calcium-zinc gluconate granules. Background technique [0002] Calcium zinc gluconate granule is a calcium and zinc supplement preparation. Calcium in the human body participates in the formation of bones and the reconstruction of bone tissue after fractures, as well as muscle contraction, nerve transmission, blood coagulation inhibition, and reduces the permeability of capillaries; Zinc is an important component of many enzymes in the body, which can promote growth and development, improve Taste and so on. When lacking, growth stagnation, reproductive impotence, difficult wound healing, body weakness, conjunctivitis, stomatitis, glossitis, loss of appetite, chronic diarrhea, loss of taste and neurological symptoms may also occur. [0003] Calcium zinc gluconate granules are used for the treatm...

Claims

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Application Information

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IPC IPC(8): G01N21/31G01N1/28
Inventor 王超志涂涛
Owner GUIZHOU LIANSHENG PHARMA
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