Pharmaceutical composition with facial whitening and spot lightening effects and preparation method and application thereof

A composition and whitening technology, applied in the direction of drug combination, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of increasing the incidence of ovarian cell chromosome exchange and chromosome aberration, contact dermatitis, poor stability, etc. To achieve the effect of inhibiting pigmentation

Inactive Publication Date: 2014-10-01
GUANGZHOU QINGLAN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the whitening chemicals used in cosmetics at home and abroad are mainly hydroquinone, kojic acid, fruit acid, arbutin and vitamin C derivatives, etc. Hydroquinone and mercury salts can achieve rapid whitening effects, but their toxic side effects are large, and long-term use will cause Causes permanent skin depigmentation and contact dermatitis
Long-term use of kojic acid has cytotoxicity and can increase t

Method used

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  • Pharmaceutical composition with facial whitening and spot lightening effects and preparation method and application thereof
  • Pharmaceutical composition with facial whitening and spot lightening effects and preparation method and application thereof
  • Pharmaceutical composition with facial whitening and spot lightening effects and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] At room temperature, take 10 kg each of small red ginseng, Pyracantha fruit, Coleus forskohlii, mulberry, trillium and saxifrage, soak and extract with 600 kg of ethanol with a volume concentration of 70%, and soak for 24 hours. The residue is soaked in 600 kg of ethanol with a volume concentration of 70% for 24 hours to extract, then the soaked solutions are combined, filtered through a 200-mesh filter screen, concentrated under reduced pressure for 20 times, and then the concentrated solution is covered with a macroporous resin. 50% ethanol is used for elution, and the collected eluate contains the active ingredient required in the prescription of the present invention, that is, the pharmaceutical composition.

Embodiment 2

[0088] At room temperature, take 8 kg of small red ginseng, 8 kg of Pyracantha fruit, 8 kg of Coleus forskohlii, 12 kg of mulberry, 12 kg of trillium and 12 kg of saxifrage, and use 1200 kg of ethanol with a volume concentration of 50%. Soaking and extraction, the soaking time is 24 hours, and the residue is soaked in 1200 kg of ethanol with a volume concentration of 50% for 24 hours to extract, and then the soaked solutions are combined, filtered through a 200-mesh filter, concentrated 40 times under reduced pressure, and then concentrated The macroporous resin on the liquid is eluted with ethanol with a volume concentration of 40%, and the collected eluate contains the active ingredients required in the prescription of the present invention, that is, the pharmaceutical composition.

Embodiment 3

[0090] At room temperature, take 8 kg of small red ginseng, 8 kg of Pyracantha fruit, 8 kg of Coleus forskohlii, 15 kg of mulberry, 15 kg of trillium and 15 kg of saxifrage, and use 1000 kg of ethanol with a volume concentration of 80%. Soaking and extraction, the soaking time is 24 hours, and the residue is soaked in 1000 kg of ethanol with a volume concentration of 80% for 24 hours to extract, and then the soaked solutions are combined, filtered through a 200-mesh filter, concentrated 25 times, and then the concentrated solution is put on a large The porous resin is eluted with ethanol with a volume concentration of 60%, and the collected eluate contains the active ingredients required in the prescription of the present invention, that is, the pharmaceutical composition.

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PUM

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Abstract

The invention discloses a pharmaceutical composition with facial whitening and spot lightening effects and a preparation method and application thereof. The raw materials of the pharmaceutical composition disclosed by the invention are natural active extracts, thereby being free of irritation to skin. The pharmaceutical composition with facial whitening and spot lightening effects is prepared from the following raw materials of rubia yunnanensis, firethorn fruits, coleus forskohlii, mulberry, cuckoopint and saxifrage, wherein the percentage by mass of any component is not greater than 40% of the total mass. The pharmaceutical composition disclosed by the invention is novel and reasonable in formula and simple in preparation method. Cell experiments, animal experiments and human experiments prove that the pharmaceutical composition is remarkable in facial whitening and spot lightening effects, safe, free of irritation or sensitization to skin and good in social and economic benefits.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a pharmaceutical composition for cosmetics with facial whitening and blemish-relieving effects and a preparation method thereof, which is suitable for being added to ointments, creams, milks, liquids (perfume) except) cosmetics. Background technique [0002] As the saying goes, "one white covers three ugliness", people have longed for a beautiful face and a moony face, as white as jade, since ancient times. Oriental women have always advocated fair skin, and whitening skin is what every girl pursues. The "Chinese Skin Typology" report hosted by Professor De La Chali, an expert in dermatology at the L'Oreal Life Science Institute, pointed out: "Compared with European women, the first thing Chinese women show in the process of skin aging is the problem of pigmentation. , and hyperpigmentation increases with age". Therefore, in China, freckle-removi...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K8/97A61P17/00A61Q19/02
Inventor 王恩瀚
Owner GUANGZHOU QINGLAN BIOTECHNOLOGY CO LTD
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