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Application of N-acetylneuraminic acid monomer or its hydrate in cosmetics

A technology of acetylneuraminic acid and cosmetics, which is applied in the field of biochemistry and cosmetics, and can solve the problem of no single component quantitative index

Inactive Publication Date: 2014-10-08
武汉中科光谷绿色生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Now many manufacturers have come up with the concept of bird’s nest extract, but the extract is mixed with multiple components, and different components have different effects, and there is no quantitative index for a single component for people’s reference, which is hard to convince

Method used

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  • Application of N-acetylneuraminic acid monomer or its hydrate in cosmetics
  • Application of N-acetylneuraminic acid monomer or its hydrate in cosmetics
  • Application of N-acetylneuraminic acid monomer or its hydrate in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Water loss test against dry environment

[0034] 1.1 Experimental principle

[0035] Water is made up of water molecules. Water molecules are doing non-stop and irregular movement. When in a dry environment, water molecules are easy to move into the air, and the water will be lost slowly at this time.

[0036] 1.2 Experimental method

[0037]Select the saturated solution of potassium chloride to control the humidity, the humidity is 43%. In order to better simulate the actual situation of the skin, select a glass plate (glass slide) of appropriate size and paste 3M medical air-permeable tape, and evenly apply the aqueous solution of N-acetylneuraminic acid monomer on the glass plate with 3M tape On, the solution dosage is about 2mg / cm 2 , placed in a desiccator, placed in a 20°C incubator, weighed at 4 hours, 24 hours, and 48 hours respectively, and calculated the moisture retention rate. The higher the moisturizing rate, the better the moisturizing effe...

Embodiment 2

[0043] Embodiment 2: whitening experiment

[0044] 2.1 Experimental principle

[0045] People's skin color is related to the markings on the skin and the deposition of pigments in skin cells. Among them, the synthesis of melanin by melanocytes in melanocytes is the main reason. The synthesis of melanin is mainly catalyzed by tyrosinase, which is a binding glycoprotein with two activities: tyrosine hydroxylase and dopa hydroxylase. The former converts tyrosine into dopa, and the latter converts dopa The whitening function of cosmetics can be evaluated by measuring the effect of cosmetics on enzyme activity.

[0046] 2.2 Experimental method

[0047] Carry out biochemical reaction in 96-well plate, add PBS buffer (pH8.0), sample solution, 0.607mg / ml L-tyrosine solution and 0.66mg / ml L-tyrosinase solution in each reaction well, The experimental system design is shown in the table below.

[0048] Experimental system for inhibition of tyrosine hydroxylase activity by N-acetylne...

Embodiment 3

[0056] Using pure water as a solvent, dissolve N-acetylneuraminic acid monomer or its hydrate to a solution with a concentration of 1% by mass, and apply it on the affected area, once in the morning and at night, and after 4 days, pus spots can be eliminated or acne can be calmed down.

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PUM

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Abstract

The invention relates to an application of an N-acetylneuraminic acid monomer or its hydrate in cosmetics. The N-acetylneuraminic acid monomer or its hydrate has the efficacies of moisture retention, whitening, inflammation eliminating, acne eliminating and ageing resisting. The N-acetylneuraminic acid monomer having a moisture retention efficacy can maintain water in skins; the N-acetylneuraminic acid monomer having a whitening efficacy can effectively inhibit the generation of melanin in skin cells; the N-acetylneuraminic acid monomer having inflammation and acne eliminating efficacies can accelerate the elimination of inflammations and acnes; and the N-acetylneuraminic acid monomer having an ageing resisting efficacy is an important component of glycoprotein on the cell membrane, and has substantial effects on intercellular adhesion and cell elasticity guaranteeing.

Description

technical field [0001] The invention relates to the fields of biochemistry and cosmetics, in particular to a compound N-acetylneuraminic acid monomer or a hydrate thereof for moisturizing, whitening, anti-inflammatory, acne-removing and anti-aging. The present invention also relates to cosmetic compositions comprising N-acetylneuraminic acid monomers or hydrates thereof. technical background [0002] Heart of beauty in everyone. In modern social life, a beautiful appearance is even more important, but at the same time, affected by various environmental changes and life and work pressure, many people have various problems in skin care. Especially young people in adolescence, with strong metabolism and a lot of skin secretions, often develop pimples, freckles, etc.; and middle-aged and elderly people also have chloasma, acne, and dry skin due to the aging of skin cells and low metabolic function , Reduced skin elasticity and other issues. [0003] At present, there are many...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61Q19/00A61Q19/02A61Q19/08A61Q19/10A61Q1/04A61Q1/10A61P17/10
Inventor 刘洋王纪袁方姚建铭陈祥松袁丽霞
Owner 武汉中科光谷绿色生物技术有限公司
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