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Anti-fatigue microemulsion and preparation method thereof

A microemulsion, anti-fatigue technology, applied in emulsion delivery, antidote, pharmaceutical formulations, etc., can solve problems such as easy side effects, cardiac pressure, etc., to avoid first-pass effect of liver and intestine, maintain stable effect, and improve body surface absorption. area effect

Active Publication Date: 2014-10-22
ANHUI KANGYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the increase of adrenaline in the blood, it also puts more pressure on the heart and is prone to side effects

Method used

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  • Anti-fatigue microemulsion and preparation method thereof
  • Anti-fatigue microemulsion and preparation method thereof
  • Anti-fatigue microemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 80 parts of ginsenoside, 80 parts of gypenoside and 100 parts of gelatin, heat and mix at 80°C. Another 20 parts of polyethylene terephthalate particles were dissolved in 200 ml of dichloromethane, a certain volume and concentration of gelatin aqueous solution was added, and the mixture was continuously stirred.

[0025] The above two were mixed, stirred and dispersed for 30 minutes to obtain a W / O emulsion. Add 1600 ml of 8% gelatin aqueous solution to the W / O emulsion, stir and disperse for 30 minutes to make a W / O / W emulsion. The above emulsion was distilled at 40°C, distilled out the oil phase capsule wall solvent methylene chloride, filtered, washed, dried and shaped to obtain a microcapsule sample.

[0026] Finally, add dilute gelatin solution to the above-mentioned microcapsule sample, then add herbal essential oil, laurocapram, gum arabic and menthol in the prescribed amount, make a microcapsule emulsion under high-speed stirring, and divide it to obtain ...

Embodiment 2

[0028] Weigh 100 parts of ginsenoside, 100 parts of gypenoside and 150 parts of gelatin, heat and mix, and the heating temperature is 80°C. Another 40 parts of polyethylene terephthalate particles were dissolved in 400 parts of dichloromethane, a certain volume and concentration of gelatin aqueous solution was added, and the mixture was continuously stirred.

[0029] The above two were mixed, stirred and dispersed for 30 minutes to obtain a W / O emulsion. Add 100 parts of 15% gelatin aqueous solution to the W / O emulsion, stir and disperse for 30 minutes to make a W / O / W emulsion. The above emulsion was distilled at 40°C, distilled out the oil phase capsule wall solvent methylene chloride, filtered, washed, dried and shaped to obtain a microcapsule sample.

[0030] Finally, add dilute gelatin solution to the above-mentioned microcapsule sample, then add herbal essential oil, laurocapram, gum arabic and menthol in the prescribed amount, make a microcapsule emulsion under high-spe...

Embodiment 3

[0032] Investigate the impact of the different consumptions of emulsifier gelatin on the emulsion of the present invention, the results are as shown in table 1:

[0033]

[0034] Other preparation conditions are the same as in Example 1, and the results show that the average particle size of the microcapsules becomes smaller and the particle size distribution range narrows as the gelatin dosage increases while maintaining a certain capsule core / capsule wall ratio. When the amount of gelatin is 8%, the effect of the obtained microcapsules is better, which is conducive to the formation of a stable emulsion system.

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Abstract

The invention discloses an anti-fatigue microemulsion and a preparation method thereof. The anti-fatigue microemulsion mainly comprises ginsenoside, gypenoside, menthol, azone, gelatin, Arabic gum, herbal essential oil, poly(diethyl terephthalate), dichloromethane and purified water. A lot of screening and animal experiments prove that the anti-fatigue microemulsion for external use has good fatigue resistance and improves immunization efficacy.

Description

technical field [0001] The invention relates to an anti-fatigue microemulsion and a preparation method thereof, in particular to an external emulsion for fatigue-prone people and a preparation method thereof, belonging to the application field of natural plant extracts. Background technique [0002] Work pressure and intensity in modern society are high, and most people are in a sub-health state. Long-term fatigue can cause a series of complications. Fatigue is a physiological phenomenon in which the body's work efficiency is temporarily and obviously reduced due to long-term heavy and intense labor under certain environmental conditions. Improving the body's tolerance to hypoxia, improving and correcting the fatigue state is of great significance for ensuring that the human body is in a healthy state under heavy and stressful work conditions. [0003] At present, anti-fatigue products on the market often add caffeine, which directly acts on the central nervous system to s...

Claims

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Application Information

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IPC IPC(8): A61K36/424A61K9/107A61K47/42A61P39/00A61K31/704A61K31/045A61K47/32
Inventor 梁承远宋慧慧王兰
Owner ANHUI KANGYUAN PHARMA CO LTD
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