Anti-fatigue microemulsion and preparation method thereof

A microemulsion, anti-fatigue technology, applied in emulsion delivery, antidote, pharmaceutical formulations, etc., can solve problems such as easy side effects, cardiac pressure, etc., to avoid first-pass effect of liver and intestine, maintain stable effect, and improve body surface absorption. area effect

Active Publication Date: 2014-10-22
ANHUI KANGYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the increase of adrenaline in the blood, it al

Method used

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  • Anti-fatigue microemulsion and preparation method thereof
  • Anti-fatigue microemulsion and preparation method thereof
  • Anti-fatigue microemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
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Example Embodiment

[0023] Example 1

[0024] Weigh 80 parts of ginsenosides, 80 parts of gypenosides and 100 parts of gelatin, and heat and mix them at a heating temperature of 80°C. Another 20 portions of polyethylene terephthalate particles were dissolved in 200 ml of dichloromethane, and a gelatin aqueous solution of a certain volume and concentration was added, and the mixture was continuously stirred.

[0025] The above two were mixed, stirred and dispersed for 30 minutes to obtain a W / O emulsion. Add 1600 ml of 8% gelatin aqueous solution to the W / O emulsion, stir and disperse for 30 minutes to make a W / O / W emulsion. The above-mentioned emulsion was distilled at 40° C., the oily capsule wall solvent methylene chloride was distilled out, filtered, washed, dried and formed into a microcapsule sample.

[0026] Finally, the gelatin dilute solution is added to the microcapsule sample, and the prescription amount of herbal essential oil, azone, gum arabic and menthol are added, and the microcapsule e...

Example Embodiment

[0027] Example 2

[0028] Weigh 100 parts of ginsenosides, 100 parts of gypenosides, and 150 parts of gelatin, and heat and mix them at a heating temperature of 80°C. Another 40 parts of polyethylene terephthalate particles were dissolved in 400 parts of dichloromethane, and a gelatin aqueous solution of a certain volume and concentration was added, and stirring was continued.

[0029] The above two were mixed, stirred and dispersed for 30 minutes to obtain a W / O emulsion. Add 100 parts of 15% gelatin aqueous solution to W / O emulsion, stir and disperse for 30 minutes to make W / O / W emulsion. The above-mentioned emulsion was distilled at 40° C., the oily capsule wall solvent methylene chloride was distilled out, filtered, washed, dried and formed into a microcapsule sample.

[0030] Finally, the gelatin dilute solution is added to the microcapsule sample, and the prescription amount of herbal essential oil, azone, gum arabic and menthol are added, and the microcapsule emulsion is pre...

Example Embodiment

[0031] Example 3

[0032] The effects of different dosages of emulsifier gelatin on the emulsion of the present invention were investigated, and the results are shown in Table 1:

[0033]

[0034] Other preparation conditions were the same as in Example 1. The results showed that with the increase of the amount of gelatin, the average particle size of the microcapsules became smaller and the particle size distribution range became narrower while maintaining a certain ratio of capsule core to capsule wall. When the amount of gelatin is 8%, the obtained microcapsules have better effect, which is conducive to forming a stable emulsion system.

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Abstract

The invention discloses an anti-fatigue microemulsion and a preparation method thereof. The anti-fatigue microemulsion mainly comprises ginsenoside, gypenoside, menthol, azone, gelatin, Arabic gum, herbal essential oil, poly(diethyl terephthalate), dichloromethane and purified water. A lot of screening and animal experiments prove that the anti-fatigue microemulsion for external use has good fatigue resistance and improves immunization efficacy.

Description

technical field [0001] The invention relates to an anti-fatigue microemulsion and a preparation method thereof, in particular to an external emulsion for fatigue-prone people and a preparation method thereof, belonging to the application field of natural plant extracts. Background technique [0002] Work pressure and intensity in modern society are high, and most people are in a sub-health state. Long-term fatigue can cause a series of complications. Fatigue is a physiological phenomenon in which the body's work efficiency is temporarily and obviously reduced due to long-term heavy and intense labor under certain environmental conditions. Improving the body's tolerance to hypoxia, improving and correcting the fatigue state is of great significance for ensuring that the human body is in a healthy state under heavy and stressful work conditions. [0003] At present, anti-fatigue products on the market often add caffeine, which directly acts on the central nervous system to s...

Claims

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Application Information

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IPC IPC(8): A61K36/424A61K9/107A61K47/42A61P39/00A61K31/704A61K31/045A61K47/32
Inventor 梁承远宋慧慧王兰
Owner ANHUI KANGYUAN PHARMA CO LTD
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