Gold nanorod multifunctional probe-based nuclide-cerenkov luminescence-CT multi-mode imaging method

A multifunctional probe and gold nanorod technology, applied in the field of biomedical imaging, can solve the problem that a single imaging modality cannot provide sufficient and comprehensive information for disease diagnosis, achieve no toxic side effects, improve spatial resolution, and increase imaging time Effect

Inactive Publication Date: 2014-10-29
XIDIAN UNIV
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Problems solved by technology

[0005] A single imaging modality cannot provide comprehensive enough information for disease diagnosis

Method used

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  • Gold nanorod multifunctional probe-based nuclide-cerenkov luminescence-CT multi-mode imaging method
  • Gold nanorod multifunctional probe-based nuclide-cerenkov luminescence-CT multi-mode imaging method
  • Gold nanorod multifunctional probe-based nuclide-cerenkov luminescence-CT multi-mode imaging method

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Embodiment Construction

[0042] The present invention will be further described below in conjunction with the accompanying drawings. It should be noted that this embodiment is based on the technical solution and provides detailed implementation modes and implementation steps, but is not limited to this embodiment.

[0043] Such as figure 1 As shown, the nuclide-Cerenkov luminescence-CT multimodal imaging method based on the gold nanorod multifunctional probe comprises the following steps:

[0044] Preparation of gold nanorods (AuNRs):

[0045] When the temperature is 27-30°C, add 5ml, 0.5mM chloroauric acid to 5ml, 0.2M CTAB, stir slowly, and the solution is light yellow at this time. Then slowly, 0.6ml, 0.01M sodium borohydride at freezing point was added dropwise, and stirred rapidly for 2min. At this time, the solution changed from light yellow to light brown, and finally turned into wine red, and seed crystals were formed. Store at 30°C for subsequent experiments.

[0046] Under the condition o...

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Abstract

The invention discloses a gold nanorod multifunctional probe-based nuclide-cerenkov luminescence-CT multi-mode imaging method, which applies a <68>Ga-AuNRs-RGD multifunctional molecular probe to the field of multi-mode molecular imaging. The caudal vein of a tumor-bearing mouse is injected with the <68>Ga-AuNRs-RGD multifunctional molecular probe, nuclide-CT imaging is performed by a PET / CT imaging system, cerenkov luminescence-CT imaging is performed by a CLI / CT (cerenkov luminescence imaging / computed tomography) system, and a PET / CT image serving as a source image and a CLI / CT image serving as a target image are fused by means of grey rectification to obtain a nuclide-cerenkov luminescence-CT multi-mode imaging display image based on the <68>Ga-AuNRs-RGD multifunctional molecular probe. According to the method, the <68>Ga-AuNRs-RGD multifunctional molecular probe is applied to multi-mode molecular imaging, has the advantages of increasing optical signal intensity, improving imaging resolution, improving imaging depth and the like, and has the characteristics of excellent dispersion, low toxicity, high living cell membrane permeability and the like.

Description

technical field [0001] The invention relates to the field of biomedical imaging, in particular to a nuclide-Cerenkov luminescence-CT multimode imaging method based on a gold nanorod multifunctional probe. Background technique [0002] The development of nanotechnology has led to the birth of a group of nanomaterials with unique optical, electrical, and magnetic properties, which are widely used in the diagnosis and treatment of tumors. Noble metal nanomaterials, especially gold nanoparticles, have highly tunable optical properties that can greatly enhance the absorption of visible light and near-infrared light. Become a new means of cancer clinical treatment. [0003] At present, the gold nanoparticles used in the field of imaging are mostly gold nanoparticles with uniform size, good colloidal stability, and less than 50nm. These nanoparticles are spherical, shell-packed, rod-shaped, and cage-shaped. Technical use. Gold nanoparticles can effectively prolong the residence ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/08A61K49/04
Inventor 屈晓超梁敬宁王彦然李蕾李奕辰梁继民
Owner XIDIAN UNIV
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