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A pharmaceutical composition for preventing and treating chemical liver injury and its pharmaceutical application

A technology of acute liver injury and composition, applied in the field of medicine, can solve the problems of combined toxicity and achieve the effects of resisting serum ALT, promoting nuclear translocation, and increasing patient compliance

Active Publication Date: 2017-10-10
JILIN BAINIAN HANKE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4. Combined toxicity
[0005] At present, in terms of protecting the liver, there is no therapeutic drug that uses rubidin or the combination of glucuronolactone and rubidin as the main active ingredient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Effect test of glucuronolactone combined with rubidin on APAP-induced acute liver injury model

[0020] 50 clean-grade Kunming mice, male, weighing 18-22 g, were reared in separate cages, free to eat and drink, and exposed to natural circadian rhythm light. The animals were randomly divided into the following three groups: normal control group, model control group, glucuronolactone group, rubidin group, and drug combination group, with 10 animals in each group. Each group was intragastrically given the corresponding test substance (dissolved or suspended in 0.5% CMC-Na solution) in the following doses:

[0021] Normal control group: 0.5% CMC-Na solution, 0.1mL / 10g / d;

[0022] Model control group: 0.5% CMC-Na solution, 0.1mL / 10g / d;

[0023] Glucurolactone group: 300mg / kg / d glucuronolactone;

[0024] Rubioside group: 100mg / kg / d Rubioside;

[0025] Drug combination group: 150mg / kg / d glucuronolactone + 50mg / kg / d rubikin.

[0026] Each group was intragastrical...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating chemical liver injury and pharmaceutical use thereof. The pharmaceutical composition contains such active ingredients as mollugin, or mollugin and glucurolactone. The pharmaceutical composition is capable of obviously resisting rise of ALT (Alanine Amino Transferase), AST (Aspartate Amino Transferase) and LDH (Lactate Dehydrogenase) levels in the serum and liver cell necrosis due to the liver injury caused by APAP (Acetaminophen), inhibiting the consumption of the reduced glutathione in the liver cells and activating the Nrf2-ARE signal path, thereby reducing the degree of the APAP induced liver injury.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for preventing and treating chemical liver injury and its pharmaceutical application. Background technique [0002] The liver is the largest and most important digestive gland in the human digestive system and has an important digestive function. It performs its powerful defense and detoxification function against many harmful factors external to the human body and produced by metabolism. Under normal circumstances, the liver has a strong biotransformation and detoxification function for foreign chemical poisons, mainly in the following four ways: 1. Oxidation and detoxification. For example, alcohol is the main harmful chemical in many people's drinking. , which are oxidized into aldehydes and acids in sequence, and other alcohols and aldehydes are also converted into acids according to this mode. The acid combines with other substances...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K31/7048A61P1/16
Inventor 任巍张丹张恒张戈
Owner JILIN BAINIAN HANKE PHARM CO LTD