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Method for preparing glossy privet fruit and astragalus membranaceus body-resistance-strengthening preparation

A technology of Zhenqi Fuzheng preparation, which is applied in the field of preparation of Zhenqi Fuzheng preparation, can solve the problems of low extraction efficiency of active ingredients, loss of active ingredients, low extraction purity, etc., and achieve the goal of improving immunity, preventing loss, and high extraction efficiency Effect

Inactive Publication Date: 2014-11-19
GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a preparation method of Zhenqi Fuzheng preparation, which can effectively solve the problems in the prior art, especially complex process, high production cost, low extraction efficiency of active ingredients, low extraction purity, and In the process of removing impurities, it will also cause a large loss of active ingredients

Method used

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  • Method for preparing glossy privet fruit and astragalus membranaceus body-resistance-strengthening preparation
  • Method for preparing glossy privet fruit and astragalus membranaceus body-resistance-strengthening preparation
  • Method for preparing glossy privet fruit and astragalus membranaceus body-resistance-strengthening preparation

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Embodiment 1

[0046] Embodiment 1 of the present invention: a preparation method of Zhenqi Fuzheng Tablets, taking Ligustrum lucidum and Astragalus membranaceus according to a weight ratio of 1:2, and extracting Ligustrum lucidum and Astragalus membranaceus by first alcohol extraction and then water extraction, That is, add 10 times the amount of 70% ethanol to extract once, each time for 2 hours, the extract is concentrated to a clear paste with a relative density of 1.08, and it is centrifuged at a speed of 16000r / min for 30min by high-speed centrifugation, and the supernatant is concentrated and used for later use; Add 10 times the amount of water to the slag and extract once, 2 hours each time, concentrate the extract to a clear paste with a relative density of 1.08, use high-speed centrifugation at a speed of 16000r / min for 30min, take the supernatant to concentrate, and set aside; combine all The concentrated solution is added with corresponding auxiliary materials for the tablet to pr...

Embodiment 2

[0047] Example 2: A preparation method of Zhenqi Fuzheng Granules, weighing Ligustrum lucidum and Astragalus membranaceus according to a weight ratio of 1:2, and extracting Ligustrum lucidum and Astragalus membranaceus by first alcohol extraction and then water extraction, that is, adding 12 Double the amount of 80% ethanol to extract twice, each time for 3 hours, the extract was concentrated to a clear paste with a relative density of 1.10, and was centrifuged at a speed of 18000r / min for 35min by high-speed centrifugation, and the supernatant was concentrated for later use; Double the amount of water to extract twice, each time for 3 hours, the extract was concentrated to a clear paste with a relative density of 1.10, centrifuged at a speed of 18000r / min for 35min by high-speed centrifugation, and the supernatant was concentrated for later use; all concentrated solutions were combined, Zhenqi Fuzheng Granules are prepared by adding the corresponding auxiliary materials of the...

Embodiment 3

[0048] Example 3: A preparation method of Zhenqi Fuzheng Capsules. According to the weight ratio of 1:2, Ligustrum lucidum and Astragalus membranaceus are weighed, and Ligustrum lucidum and Astragalus are extracted by first alcohol extraction and then water extraction, that is, adding 8 Extract once with 60% ethanol, 1 hour each time, concentrate the extract to a clear cream with a relative density of 1.06, centrifuge at a speed of 13000r / min for 20min by high-speed centrifugation, concentrate the supernatant, and set aside; add 8 Extract with twice the amount of water once, 1 hour each time, concentrate the extract to a clear paste with a relative density of 1.06, use high-speed centrifugation at a speed of 13000r / min for 20min, take the supernatant to concentrate, and set aside; combine all the concentrates, Zhenqi Fuzheng Capsules were prepared by adding the corresponding auxiliary materials of the capsules. The Zhenqi Fuzheng Capsule is taken orally, and the dosage is 15g ...

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Abstract

The invention discloses a method for preparing a glossy privet fruit and astragalus membranaceus body-resistance-strengthening preparation. The method comprises the following steps: weighing glossy privet fruit and astragalus membranaceus in a weight ratio of 1:2, and extracting by using water and ethanol as solvents; respectively concentrating water extract and ethanol extract to obtain extract with relative density of 1.02-1.12; respectively centrifuging for 15-40 minutes with a rotating speed of 10000-20000r / min, taking supernatant and concentrating for later use; combining all concentrates, and adding corresponding auxiliaries to prepare a pharmaceutically acceptable preparation. According to the method, the glossy privet fruit and the astragalus membranaceus are extracted, and then effective components in the concentrated extract are purified by adopting a high-speed centrifuging method. The method is simple in extraction process, strong in operability and high in extraction efficiency, and the purities of extracted effective components are relatively higher. Furthermore, the glossy privet fruit and astragalus membranaceus body-resistance-strengthening preparation prepared by utilizing the method can relatively well protect functions of myelic adrenal cortex and liver, and is capable of further improving body immunity.

Description

technical field [0001] The invention relates to a preparation method of Zhenqi Fuzheng preparation, which belongs to the technical field of traditional Chinese medicine. Background technique [0002] Zhenqi Fuzheng Medicine is a drug produced by combining plant medicines Astragalus and Ligustrum lucidum to improve immunity and treat leukopenia caused by radiotherapy or chemotherapy. The dosage forms of Zhenqi Fuzheng medicine currently available for clinical selection include tablets, capsules, granules, dripping pills and syrups, etc. Most of these dosage forms use solvent extraction, precipitation, filtration and dialysis to remove insoluble impurities, which is not only complicated , the production cost is high, the extraction efficiency of the active ingredient is low, the extraction purity is low, and it will also cause a large loss of the active ingredient in the process of removing impurities. [0003] The patent application with the application number 201110376504.X...

Claims

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Application Information

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IPC IPC(8): A61K36/638A61P37/04A61K36/481
Inventor 张观福
Owner GUIZHOU XINBANG PHARMACEUTICAL CO LTD