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Method for preparing anti-infectious artificial ligament

An artificial ligament and anti-infection technology, applied in the field of biomedicine, can solve problems such as artificial ligament synovitis, achieve the effect of solving uneven coating, good market application prospects, and simple preparation process

Inactive Publication Date: 2014-11-19
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a method for preparing an anti-infection artificial ligament in view of the above-mentioned defects in the prior art; it mainly solves the problem that the exposure of the artificial ligament in clinical application will cause synovitis due to infection

Method used

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  • Method for preparing anti-infectious artificial ligament
  • Method for preparing anti-infectious artificial ligament
  • Method for preparing anti-infectious artificial ligament

Examples

Experimental program
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Effect test

Embodiment 1

[0034] At room temperature, with water as solvent, 5ml50mmol / L of AgN0 3 and 5ml of 25mg / L porcine gelatin solution, adjust the pH value to 8, then add 100ul freshly prepared 10mM ascorbic acid solution, stir and react at 25°C for 30min, to obtain a nano-silver coating solution.

[0035] The artificial ligament made of PET material was ultrasonically cleaned for 10 minutes, rinsed three times with ultrapure water, dried in vacuum, and treated with corona for 5 minutes to obtain a PET artificial ligament with a surface tension value of 65 mNm, which was dried in vacuum for later use.

[0036] Under the condition of 37°C, soak the artificial ligament in the nano-silver coating solution obtained above, stir and react for 30 minutes, so that the nano-coating in the system is fully combined with the surface of the artificial ligament, take out the artificial ligament and dry it in vacuum, repeat the above steps 5 times, Through scanning electron microscope observation, a new type o...

Embodiment 2

[0041]At room temperature, with water as solvent, 10ml10mmol / L of AgN0 3 Mix with 25ml of 25mg / L rabbit gelatin solution, adjust the pH value to 8, then add 100ul freshly prepared 100mM ascorbic acid solution, stir and react at 60°C for 120min to obtain a nano-silver coating solution.

[0042] The artificial ligament made of PET material was ultrasonically cleaned for 5 minutes, rinsed three times with ultrapure water, dried in vacuum, and treated with corona for 20 minutes to obtain an artificial ligament with a surface tension value of 85 mN / m, which was dried in vacuum for later use.

[0043] Under the condition of 70°C, soak the artificial ligament in the nano-silver coating solution obtained above, stir and react for 10 minutes, so that the nano-coating in the system is fully combined with the surface of the PET material, take out the filter paper to dry, repeat the above steps 30 times, and get A new type of artificial ligament with nano-silver coating thickness between ...

Embodiment 3

[0045] At room temperature, with water as solvent, 10ml50mmol / L of AgN0 3 Mix with 50ml of 10mg / L bovine gelatin solution, adjust the pH value to 7, then add 100ml of freshly prepared 80mM ascorbic acid solution, stir and react at 35°C for 30min to obtain a nano-silver coating solution.

[0046] The artificial ligament made of PET material was ultrasonically cleaned for 20 minutes, rinsed three times with ultrapure water, vacuum-dried, and corona treated for 3 minutes to obtain a PET ligament with a surface tension value of 45 mN / m, which was vacuum-dried for later use.

[0047] Under the condition of 37°C, soak the artificial ligament in the nano-silver solution obtained above, stir and react for 14 minutes, so that the nano-coating in the system is fully combined with the surface of the PET material, take out the filter paper to dry, repeat the above steps 10 times, and obtain the nano-silver Artificial ligament with silver coating thickness between 100±18.6nm.

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Abstract

The invention provides a method for preparing an anti-infectious artificial ligament. The method specifically comprises the following steps: performing ultrasonic cleaning on a PET artificial ligament to remove surface dirt; performing corona treatment on the PET artificial ligament; preparing a nano-silver surface coating solution; coating the surface of the PET artificial ligament; and cleaning and performing vacuum drying. The thickness of the nano-silver coating on the surface of the artificial ligament is 50-300nm, and the biocompatibility and osteoconduction of the artificial ligament can be improved, so that the artificial ligament has antibacterial and anti-inflammatory performances and meets the requirements of clinical medicine in aspects such as biological activity and mechanical property.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a preparation method of an anti-infection artificial ligament, specifically adopting a silver coating to improve the biocompatibility and osteoconductivity of the artificial ligament made of PET material, so that the artificial ligament has antibacterial and anti-inflammatory properties. Background technique [0002] Polyethylene terephthalate (PET) artificial ligament is the graft choice for the reconstruction of knee cruciate ligament injury. A number of clinical studies have proved that its short-term curative effect and safety after operation are relatively satisfactory. Capacitive problems, synovitis, infection and other complications will occur; and the inflammatory products in the synovial fluid of the joint will destroy the structure of the joint and affect the healing of the tendon and bone. These become one of the important factors leading to the failure of knee cruciate ligame...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/30A61L27/54
Inventor 陈俊陈世益张鹏蒋佳吴子英陈天午万方
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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